Publications by authors named "Keisuke Kuida"

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Phase 1 first-in-human dose-expansion study of the oral SF3B1 modulator H3B‑8800 in lower-risk myelodysplastic syndrome.
James M Foran, Guillermo F Sanz, Justin M Watts, Andrew M Brunner, Gaelle Fossard, Keisuke Kuida

Leuk Res· September 2025

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Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms.
David P Steensma, Martin Wermke, Virginia M Klimek, Peter L Greenberg, Patricia Font, Keisuke Kuida

Leukemia· December 2021

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Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation.
Susan M Keating, D Lansing Taylor, Anne L Plant, E David Litwack, Peter Kuhn, Keisuke Kuida

Clin Transl Sci· May 2018

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Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer.
Peter J Klauck, Stacey M Bagby, Anna Capasso, Erica L Bradshaw-Pierce, Heather M Selby, Keisuke Kuida

BMC Cancer· February 2018

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A First-in-Human, Phase I, Dose-Escalation Study of TAK-117, a Selective PI3Kα Isoform Inhibitor, in Patients with Advanced Solid Malignancies.
Dejan Juric, Johann S de Bono, Patricia M LoRusso, John Nemunaitis, Elisabeth I Heath, Keisuke Kuida

Clin Cancer Res· September 2017

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An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924).
Hiroyuki Sumi, Masakazu Inazuka, Megumi Morimoto, Ryosuke Hibino, Kentaro Hashimoto, Keisuke Kuida

Biochem Biophys Res Commun· November 2016

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Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells.
Keiko Nonomura, Yoshifumi Yamaguchi, Misato Hamachi, Masato Koike, Yasuo Uchiyama, Keisuke Kuida

Dev Cell· December 2013

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TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens.
Yuichi Hikichi, Kohei Honda, Kouki Hikami, Hitoshi Miyashita, Isao Kaieda, Keisuke Kuida

Mol Cancer Ther· March 2012

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Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure.
Yoshifumi Yamaguchi, Naomi Shinotsuka, Keiko Nonomura, Kiwamu Takemoto, Keisuke Kuida

J Cell Biol· December 2011

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Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity.
Shizue Ohsawa, Shun Hamada, Keisuke Kuida, Hiroki Yoshida, Tatsushi Igaki

Proc Natl Acad Sci U S A· July 2010

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Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury.
Masato Koike, Masahiro Shibata, Masao Tadakoshi, Kunihito Gotoh, Masaaki Komatsu, Keisuke Kuida

Am J Pathol· February 2008

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(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18.
Woods Wannamaker, Robert Davies, Mark Namchuk, John Pollard, Pamella Ford, Keisuke Kuida

J Pharmacol Exp Ther· May 2007

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Decreased retinal neuronal cell death in caspase-1 knockout mice.
Jun Arai, Naomichi Katai, Keisuke Kuida, Takanobu Kikuchi, Nagahisa Yoshimura

Jpn J Ophthalmol· November 2006

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The initiator caspase, caspase-10beta, and the BH-3-only molecule, Bid, demonstrate evolutionary conservation in Xenopus of their pro-apoptotic activities in the extrinsic and intrinsic pathways.
Katsuya Kominami, Chiyo Takagi, Tomoko Kurata, Atsushi Kitayama, Masami Nozaki, Keisuke Kuida

Genes Cells· July 2006

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The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection.
Dario S Zamboni, Koichi S Kobayashi, Tiana Kohlsdorf, Yasunori Ogura, E Michelle Long, Keisuke Kuida

Nat Immunol· March 2006

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Caspases 3 and 7: key mediators of mitochondrial events of apoptosis.
Saquib A Lakhani, Ali Masud, Keisuke Kuida, George A Porter, Carmen J Booth

Science· February 2006

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c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo.
Zhili Shao, Kausik Bhattacharya, Eileen Hsich, Larry Park, Brian Walters, Keisuke Kuida

Circ Res· January 2006

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Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells.
Masatoshi Ohgushi, Shunsuke Kuroki, Hiroshi Fukamachi, Lorraine A O'Reilly, Keisuke Kuida

Mol Cell Biol· November 2005

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Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis.
Koji Oishi, Sachiko Kamakura, Yuko Isazawa, Takeshi Yoshimatsu, Keisuke Kuida

Dev Biol· December 2004

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Functions of MAP kinases: insights from gene-targeting studies.
Keisuke Kuida, Diane M Boucher

J Biochem· June 2004

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Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease.
Thomas Force, Keisuke Kuida, Mark Namchuk, Keykavous Parang, John M Kyriakis

Circulation· March 2004

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Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo.
Hiroshi Takuma, Takami Tomiyama, Keisuke Kuida, Hiroshi Mori

J Neuropathol Exp Neurol· March 2004

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Roles of caspase-1 in Listeria infection in mice.
Noriko M Tsuji, Hiroko Tsutsui, Ekihiro Seki, Keisuke Kuida, Haruki Okamura

Int Immunol· February 2004

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Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation.
Yao Yao, Wei Li, Junwei Wu, Ursula A Germann, Michael S S Su, Keisuke Kuida

Proc Natl Acad Sci U S A· October 2003

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Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation.
Dean A Le, Yongqin Wu, Zhihong Huang, Kohji Matsushita, Nikolaus Plesnila, Keisuke Kuida

Proc Natl Acad Sci U S A· November 2002

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