Publications by authors named "Larry Park"

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Extramedullary plasmacytoma of the oral cavity metastasising to both kidneys in a dog.
Kyung Ho Park, Tae-Un Kim, Hyun-Woo Park, Seoung-Woo Lee, Su-Min Baek, Sang-Joon Park, Larry Chong Park, Jin-Kyu Park

Vet Med Sci· May 2023

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HDinHD: A Rich Data Portal for Huntington's Disease Research.
Jeff Aaronson, Vahri Beaumont, Richard A Blevins, Viktoria Andreeva, Irina Murasheva, Larry C Park

J Huntingtons Dis· January 2022

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Global Rhes knockout in the Q175 Huntington's disease mouse model.
Taneli Heikkinen, Timo Bragge, Juha Kuosmanen, Teija Parkkari, Sanna Gustafsson, Larry Park

PLoS One· November 2021

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Transcriptional Assessment of Striatal mRNAs as Valid Biomarkers of Disease Progression in Three Mouse Models of Huntington's Disease.
Afshin Ghavami, Michael Olsen, Mei Kwan, Jose Beltran, John Shea, Larry C Park

J Huntingtons Dis· April 2021

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NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model.
Daniele Moretti, Sara Tambone, Mauro Cerretani, Paola Fezzardi, Antonino Missineo, Larry Park

Free Radic Biol Med· January 2021

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Rapid and robust patterns of spontaneous locomotor deficits in mouse models of Huntington's disease.
Taneli Heikkinen, Timo Bragge, Niina Bhattarai, Teija Parkkari, Jukka Puoliväli, Larry C Park

PLoS One· January 2021

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Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
Stefania Colarusso, Daniele De Simone, Tommaso Frattarelli, Matteo Andreini, Mauro Cerretani, Larry Park

Bioorg Med Chem· November 2020

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Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction.
Jesus M Ontoria, Ilaria Biancofiore, Paola Fezzardi, Federica Ferrigno, Esther Torrente, Larry Park

ACS Med Chem Lett· May 2020

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Improved synthesis of [F] fallypride and characterization of a Huntington's disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2/D3 receptors.
Tuulia Huhtala, Pekka Poutiainen, Jussi Rytkönen, Kimmo Lehtimäki, Teija Parkkari, Larry C Park

EJNMMI Radiopharm Chem· August 2019

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Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease.
Bryan Zeitler, Steven Froelich, Kimberly Marlen, David A Shivak, Qi Yu, Larry Park

Nat Med· July 2019

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Age- and sex-related changes in cortical and striatal nitric oxide synthase in the Q175 mouse model of Huntington's disease.
Fernando E Padovan-Neto, Lauren Jurkowski, Conor Murray, Grace E Stutzmann, Mei Kwan, Larry C Park

Nitric Oxide· February 2019

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Impaired Performance of the Q175 Mouse Model of Huntington's Disease in the Touch Screen Paired Associates Learning Task.
Tuukka O Piiponniemi, Teija Parkkari, Taneli Heikkinen, Jukka Puoliväli, Larry C Park

Front Behav Neurosci· October 2018

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Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).
Alberto Bresciani, Antonino Missineo, Mariana Gallo, Mauro Cerretani, Paola Fezzardi, Larry C Park

Arch Biochem Biophys· October 2017

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Novel Metabolic Abnormalities in the Tricarboxylic Acid Cycle in Peripheral Cells From Huntington's Disease Patients.
Nima N Naseri, Joseph Bonica, Hui Xu, Larry C Park, Jamshid Arjomand

PLoS One· August 2017

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Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington's Disease Models.
Vahri Beaumont, Sheng Zhong, Hai Lin, WenJin Xu, Amyaouch Bradaia, Larry Park

Neuron· December 2016

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The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease.
Vahri Beaumont, Ladislav Mrzljak, Ulrike Dijkman, Robert Freije, Mariette Heins, Larry C Park

Exp Neurol· August 2016

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Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD.
Paul C P Curtin, Andrew M Farrar, Stephen Oakeshott, Jane Sutphen, Jason Berger, Larry C Park

Front Behav Neurosci· January 2016

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Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease.
Liliana B Menalled, Andrea E Kudwa, Steve Oakeshott, Andrew Farrar, Neil Paterson, Larry Park

PLoS One· October 2015

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Abnormalities in the tricarboxylic Acid cycle in Huntington disease and in a Huntington disease mouse model.
Nima N Naseri, Hui Xu, Joseph Bonica, Jean Paul G Vonsattel, Etty P Cortes, Larry C Park

J Neuropathol Exp Neurol· June 2015

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Cognitive deficits in transgenic and knock-in HTT mice parallel those in Huntington's disease.
Andrew M Farrar, Carol A Murphy, Neil E Paterson, Stephen Oakeshott, Dansha He, Larry C Park

J Huntingtons Dis· September 2014

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The PDE1/5 Inhibitor SCH-51866 Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease.
Vahri Beaumont, Larry Park, Arash Rassoulpour, Ulrike Dijkman, Taneli Heikkinen

PLoS Curr· February 2014

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HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
Michal Mielcarek, Christian Landles, Andreas Weiss, Amyaouch Bradaia, Tamara Seredenina, Larry Park

PLoS Biol· November 2013

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Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.
Liliana B Menalled, Andrea E Kudwa, Sam Miller, Jon Fitzpatrick, Judy Watson-Johnson, Larry C Park

PLoS One· June 2013

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Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.
Taneli Heikkinen, Kimmo Lehtimäki, Nina Vartiainen, Jukka Puoliväli, Susan J Hendricks, Larry C Park

PLoS One· June 2013

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A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease.
Libo Yu-Taeger, Elisabeth Petrasch-Parwez, Alexander P Osmand, Adriana Redensek, Silke Metzger, Larry Park

J Neurosci· October 2012

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