Publications by authors named "Keith Wafford"

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Improved Sleep, Memory, and Cellular Pathological Features of Tauopathy, Including the NLRP3 Inflammasome, after Chronic Administration of Trazodone in rTg4510 Mice.
Paula de Oliveira, Claire Cella, Nicolas Locker, Kiran K G Ravindran, Agampodi Mendis, Keith Wafford

J Neurosci· April 2022

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The Dopamine D1 Receptor Positive Allosteric Modulator Mevidalen (LY3154207) Enhances Wakefulness in the Humanized D1 Mouse and in Sleep-Deprived Healthy Male Volunteers.
Andrew P McCarthy, Kjell A Svensson, Elaine Shanks, Claire Brittain, Brian J Eastwood, Keith A Wafford

J Pharmacol Exp Ther· March 2022

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Aberrant waste disposal in neurodegeneration: why improved sleep could be the solution.
Keith A Wafford

Cereb Circ Cogn Behav· August 2021

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The M1/M4 preferring muscarinic agonist xanomeline modulates functional connectivity and NMDAR antagonist-induced changes in the mouse brain.
Caterina Montani, Carola Canella, Adam J Schwarz, Jennifer Li, Gary Gilmour, Keith Wafford

Neuropsychopharmacology· May 2021

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Pharmacological Modulation of Sleep Homeostasis in Rat: Novel Effects of an mGluR2/3 Antagonist.
Nicola Hanley, Jerome Paulissen, Brian J Eastwood, Gary Gilmour, Sally Loomis, Keith A Wafford

Sleep· September 2019

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Disturbances of sleep quality, timing and structure and their relationship with other neuropsychiatric symptoms in Alzheimer's disease and schizophrenia: Insights from studies in patient populations and animal models.
Raphaelle Winsky-Sommerer, Paula de Oliveira, Sally Loomis, Keith Wafford, Derk-Jan Dijk

Neurosci Biobehav Rev· February 2019

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REM sleep's unique associations with corticosterone regulation, apoptotic pathways, and behavior in chronic stress in mice.
Mathieu Nollet, Harriet Hicks, Andrew P McCarthy, Huihai Wu, Carla S Möller-Levet, Keith A Wafford

Proc Natl Acad Sci U S A· February 2019

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Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression.
Christian M Wood, Keith A Wafford, Andrew P McCarthy, Nicola Hewes, Elaine Shanks

Neuropharmacology· September 2018

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Effects of Aging on Cortical Neural Dynamics and Local Sleep Homeostasis in Mice.
Laura E McKillop, Simon P Fisher, Nanyi Cui, Stuart N Peirson, Russell G Foster, Keith A Wafford

J Neurosci· April 2018

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Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders.
Robert F Bruns, Stephen N Mitchell, Keith A Wafford, Alex J Harper, Elaine A Shanks

Neuropharmacology· January 2018

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Electroencephalographic, cognitive, and neurochemical effects of LY3130481 (CERC-611), a selective antagonist of TARP-γ8-associated AMPA receptors.
Jeffrey M Witkin, Jennifer Li, Gary Gilmour, Stephen N Mitchell, Guy Carter, Keith A Wafford

Neuropharmacology· November 2017

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TaiNi: Maximizing research output whilst improving animals' welfare in neurophysiology experiments.
Zhou Jiang, John R Huxter, Stuart A Bowyer, Anthony J Blockeel, James Butler, Keith A Wafford

Sci Rep· August 2017

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Phase-amplitude coupled persistent theta and gamma oscillations in rat primary motor cortex in vitro.
Nicholas W Johnson, Mazhar Özkan, Adrian P Burgess, Emma J Prokic, Keith A Wafford

Neuropharmacology· June 2017

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Polypharmacological in Silico Bioactivity Profiling and Experimental Validation Uncovers Sedative-Hypnotic Effects of Approved and Experimental Drugs in Rat.
Georgios Drakakis, Keith A Wafford, Suzanne C Brewerton, Michael J Bodkin, David A Evans

ACS Chem Biol· June 2017

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Modelling maintenance of wakefulness in rats: comparing potential non-invasive sleep-restriction methods and their effects on sleep and attentional performance.
Andrew Mccarthy, Sally Loomis, Brian Eastwood, Keith A Wafford, Raphaëlle Winsky-Sommerer

J Sleep Res· April 2017

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Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour.
Christian M Wood, Celine S Nicolas, Sun-Lim Choi, Erika Roman, Ingrid Nylander, Keith A Wafford

Neuropharmacology· March 2017

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Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism.
Akihiko S Kato, Kevin D Burris, Kevin M Gardinier, Douglas L Gernert, Warren J Porter, Keith A Wafford

Nat Med· December 2016

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Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.
Bruce A Dressman, Eric G Tromiczak, Mark D Chappell, Allie E Tripp, Steven J Quimby, Keith A Wafford

Bioorg Med Chem Lett· December 2016

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Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
Mark D Chappell, Renhua Li, Stephon C Smith, Bruce A Dressman, Eric G Tromiczak, Keith A Wafford

J Med Chem· December 2016

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REM sleep homeostasis in the absence of REM sleep: Effects of antidepressants.
Andrew McCarthy, Keith Wafford, Elaine Shanks, Marcin Ligocki, Dale M Edgar

Neuropharmacology· September 2016

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Erratum: A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies.
Anke Post, Trevor S Smart, Judith Krikke-Workel, Gerard R Dawson, Catherine J Harmer, Keith Wafford

Neuropsychopharmacology· September 2016

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A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies.
Anke Post, Trevor S Smart, Judith Krikke-Workel, Gerard R Dawson, Catherine J Harmer, Keith Wafford

Neuropsychopharmacology· June 2016

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In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat.
Gary Gilmour, Lisa M Broad, Keith A Wafford, Thomas Britton, Ellen M Colvin

Neuropharmacology· January 2013

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Decoupling of sleep-dependent cortical and hippocampal interactions in a neurodevelopmental model of schizophrenia.
Keith G Phillips, Ullrich Bartsch, Andrew P McCarthy, Dale M Edgar, Mark D Tricklebank, Keith A Wafford

Neuron· November 2012

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GABA(A) Receptor Subtypes: Novel Targets for Novel Medicines.
Naheed R Mirza, John Atack, Keith Wafford

Adv Pharmacol Sci· August 2012

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