Publications by authors named "Kelly A Fader"

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Associations of Podocyte-Derived Protein Biomarkers With Foot Process Effacement and Kidney Histopathologic Lesions in Individuals With Glomerular Disease.
Insa M Schmidt, Ashish Verma, Sophie Claudel, Sophia Rosan, Weining Lu, Kelly Alana Fader

Kidney Med· December 2025

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Correction: Longitudinal evaluation of serum neurofilament light levels in normal healthy volunteers: defining a threshold of concern.
Thomas A Lanz, Klemens Ruprecht, Christopher J Somps, Jens C Göpfert, Tony Kam-Thong, Kelly A Fader

J Neurol· October 2025

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Assessment of Impact of Hemolysis in Human and Nonhuman Serum Specimens on Multiplex Cytokine Quantification.
Mitchell Thorn, Lawrence Roy Soria, Colleen M Doshna, Thi Dong Binh Tran, Dingzhou Li, Kelly A Fader

J Appl Lab Med· September 2025

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Longitudinal evaluation of serum neurofilament light levels in normal healthy volunteers: defining a threshold of concern.
Thomas A Lanz, Klemens Ruprecht, Christopher J Somps, Jens C Göpfert, Tony Kam-Thong, Kelly A Fader

J Neurol· July 2025

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Qualified kidney injury biomarkers demonstrate value during early clinical drug development.
Kodihalli C Ravindra, Kelly A Fader, David Potter, Zaher A Radi, Gary S Friedman

Toxicol Sci· October 2024

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Absence of functional deficits in rats following systemic administration of an AAV9 vector despite moderate peripheral nerve and dorsal root ganglia findings: A clinically silent peripheral neuropathy.
Cheryl Tyszkiewicz, Seo-Kyoung Hwang, Jamie K DaSilva, Ramesh C Kovi, Kelly A Fader

Neurotoxicology· March 2024

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Western blotting: evolution of an old analytical method to a new quantitative tool for biomarker measurements.
Carolina Owen, Kelly A Fader, Mohamed Hassanein

Bioanalysis· March 2024

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Thymic lymphoma detection in RORγ knockout mice using 5-hydroxymethylcytosine profiling of circulating cell-free DNA.
Kelly A Fader, Mark M Gosink, Shuhua Xia, Thomas A Lanz, Charles Halsey

Toxicol Appl Pharmacol· August 2023

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Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver.
Giovan N Cholico, Karina Orlowska, Russell R Fling, Warren J Sink, Nicholas A Zacharewski, Kelly A Fader

Sci Rep· March 2023

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Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species.
Kelly A Fader, Ingrid D Pardo, Ramesh C Kovi, Christopher J Somps, Helen Hong Wang

Mol Ther Methods Clin Dev· June 2022

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Single-Nuclei RNA Sequencing Assessment of the Hepatic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin.
Rance Nault, Kelly A Fader, Sudin Bhattacharya, Tim R Zacharewski

Cell Mol Gastroenterol Hepatol· December 2021

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Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation.
Giovan N Cholico, Russell R Fling, Nicholas A Zacharewski, Kelly A Fader, Rance Nault

Sci Rep· August 2021

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A Biomarker-Centric Approach to Drug Discovery and Development: Lessons Learned from the Coronavirus Disease 2019 Pandemic.
Kelly A Fader, Jiangwei Zhang, Joseph P Menetski, Ravi I Thadhani, Elliott M Antman

J Pharmacol Exp Ther· January 2021

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice.
Russell R Fling, Claire M Doskey, Kelly A Fader, Rance Nault, Tim R Zacharewski

Sci Rep· September 2020

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats.
Claire M Doskey, Kelly A Fader, Rance Nault, Todd Lydic, Jason Matthews

Toxicol Appl Pharmacol· July 2020

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Characterizing the Role of HMG-CoA Reductase in Aryl Hydrocarbon Receptor-Mediated Liver Injury in C57BL/6 Mice.
Peter Dornbos, Amanda Jurgelewicz, Kelly A Fader, Kurt Williams, Timothy R Zacharewski

Sci Rep· November 2019

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2,3,7,8-Tetrachlorodibenzo-p-dioxin abolishes circadian regulation of hepatic metabolic activity in mice.
Kelly A Fader, Rance Nault, Claire M Doskey, Russell R Fling, Timothy R Zacharewski

Sci Rep· April 2019

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Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo--dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction.
Rance Nault, Claire M Doskey, Kelly A Fader, Cheryl E Rockwell, Tim Zacharewski

Mol Pharmacol· August 2018

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2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice.
Kelly A Fader, Rance Nault, Sandi Raehtz, Laura R McCabe, Timothy R Zacharewski

Toxicol Appl Pharmacol· June 2018

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Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice.
Rance Nault, Kelly A Fader, Jack R Harkema, Tim Zacharewski

PLoS One· October 2017

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism.
Kelly A Fader, Rance Nault, Chen Zhang, Kazuyoshi Kumagai, Jack R Harkema

Sci Rep· July 2017

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TCDD influences reservoir of antibiotic resistance genes in murine gut microbiome.
Robert D Stedtfeld, Tiffany M Stedtfeld, Kelly A Fader, Maggie R Williams, Prianca Bhaduri

FEMS Microbiol Ecol· May 2017

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Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity.
Kelly A Fader, Rance Nault, Mathew P Kirby, Gena Markous, Jason Matthews

Toxicol Appl Pharmacol· April 2017

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Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin.
Rance Nault, Kelly A Fader, Todd A Lydic, Timothy R Zacharewski

Chem Res Toxicol· April 2017

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Beyond the Aryl Hydrocarbon Receptor: Pathway Interactions in the Hepatotoxicity of 2,3,7,8-Tetrachlorodibenzo--dioxin and Related Compounds.
Kelly A Fader, Timothy R Zacharewski

Curr Opin Toxicol· February 2017

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