Publications by authors named "Tim Zacharewski"

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Loss of Dioxin Response Element-Mediated Induction of PKM2 Reprograms Hepatic Metabolism in Response to TCDD.
Karina Orlowska, Rance Nault, Tim Zacharewski

Int J Mol Sci· November 2025

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Cell type- and species-specific regulation of hepatic lncRNAs by TCDD-activated aryl hydrocarbon receptor.
Gavin A Post, Giovan N Cholico, Rance Nault, Tim Zacharewski

Sci Rep· October 2025

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Shift in the urinary metabolome associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin activation of the hepatic aryl hydrocarbon receptor.
Warren J Sink, Russell Fling, Ali Yilmaz, Rance Nault, Delanie Goniwiecha, Tim Zacharewski

Sci Rep· July 2025

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Disruption of canonical AHR-mediated induction of hepatocyte PKM2 expression compromises antioxidant defenses and increases TCDD-induced hepatotoxicity.
Karina Orlowska, Rance Nault, Jesmin Ara, John J LaPres, Jack Harkema, Tim Zacharewski

Redox Biol· November 2024

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Cell-specific AHR-driven differential gene expression in the mouse liver cell following acute TCDD exposure.
Giovan N Cholico, Rance Nault, Tim Zacharewski

BMC Genomics· August 2024

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Inhibition of the urea cycle by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin increases serum ammonia levels in mice.
Giovan N Cholico, Russell R Fling, Warren J Sink, Rance Nault, Tim Zacharewski

J Biol Chem· January 2024

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Generative modeling of single-cell gene expression for dose-dependent chemical perturbations.
Omar Kana, Rance Nault, David Filipovic, Daniel Marri, Tim Zacharewski

Patterns (N Y)· August 2023

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A Case for Accelerating Standards to Achieve the FAIR Principles of Environmental Health Research Experimental Data.
Rance Nault, Matthew C Cave, Gabriele Ludewig, Hunter N B Moseley, Kelly G Pennell, Tim Zacharewski

Environ Health Perspect· June 2023

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Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver.
Giovan N Cholico, Karina Orlowska, Russell R Fling, Warren J Sink, Nicholas A Zacharewski, Tim Zacharewski

Sci Rep· March 2023

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Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice.
Rance Nault, Satabdi Saha, Sudin Bhattacharya, Samiran Sinha, Tapabrata Maiti, Tim Zacharewski

Toxicol Sci· January 2023

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A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds.
Rongrui Liu, Tim R Zacharewski, Rory B Conolly, Qiang Zhang

Toxics· November 2022

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Dioxin-elicited decrease in cobalamin redirects propionyl-CoA metabolism to the β-oxidation-like pathway resulting in acrylyl-CoA conjugate buildup.
Karina Orlowska, Russ R Fling, Rance Nault, Warren J Sink, Anthony L Schilmiller, Tim Zacharewski

J Biol Chem· September 2022

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Benchmarking of a Bayesian single cell RNAseq differential gene expression test for dose-response study designs.
Rance Nault, Satabdi Saha, Sudin Bhattacharya, Jack Dodson, Samiran Sinha, Tim Zacharewski

Nucleic Acids Res· May 2022

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Genome-Wide ChIPseq Analysis of AhR, COUP-TF, and HNF4 Enrichment in TCDD-Treated Mouse Liver.
Giovan N Cholico, Rance Nault, Tim R Zacharewski

Int J Mol Sci· January 2022

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Single-Nuclei RNA Sequencing Assessment of the Hepatic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin.
Rance Nault, Kelly A Fader, Sudin Bhattacharya, Tim R Zacharewski

Cell Mol Gastroenterol Hepatol· December 2021

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Genetics-Based Approach to Identify Novel Genes Regulated by the Aryl Hydrocarbon Receptor in Mouse Liver.
Amanda Jurgelewicz, Peter Dornbos, Melanie Warren, Rance Nault, Anooj Arkatkar, Tim Zacharewski

Toxicol Sci· May 2021

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice.
Russell R Fling, Claire M Doskey, Kelly A Fader, Rance Nault, Tim R Zacharewski

Sci Rep· September 2020

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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats.
Claire M Doskey, Kelly A Fader, Rance Nault, Todd Lydic, Jason Matthews, Tim Zacharewski

Toxicol Appl Pharmacol· July 2020

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A toxicogenomic approach for the risk assessment of the food contaminant acetamide.
Rance Nault, Bryan Bals, Farzaneh Teymouri, Michael B Black, Melvin E Andersen, Tim R Zacharewski

Toxicol Appl Pharmacol· February 2020

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Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo--dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction.
Rance Nault, Claire M Doskey, Kelly A Fader, Cheryl E Rockwell, Tim Zacharewski

Mol Pharmacol· August 2018

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Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice.
Rance Nault, Kelly A Fader, Jack R Harkema, Tim Zacharewski

PLoS One· October 2017

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Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis.
Rance Nault, Kelly A Fader, Dustin A Ammendolia, Peter Dornbos, Dave Potter, Tim Zacharewski

Toxicol Sci· December 2016

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RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice.
Rance Nault, Kelly A Fader, Tim Zacharewski

BMC Genomics· May 2015

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Automated dose-response analysis of the relative hepatic gene expression potency of TCDF in C57BL/6 mice.
Lyle D Burgoon, Qi Ding, Alhaji N'jai, Ed Dere, Ashley R Burg, Tim R Zacharewski

Toxicol Sci· November 2009

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Use of Xenopus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians.
Yue-wern Huang, Jason B Matthews, Kirsten C Fertuck, Tim R Zacharewski

Environ Toxicol Chem· August 2005

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