Publications by authors named "Ken Lau"

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An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations.
Matthew A Loberg, George J Xu, Sheau-Chiann Chen, Hua-Chang Chen, Claudia C Wahoski, Ken S Lau

JCI Insight· January 2026

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Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention.
Qing Li, Qingyuan Song, Zhishan Chen, Jungyoon Choi, Victor Moreno, Ken S Lau

Am J Hum Genet· December 2025

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Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia.
Vincent Quoc-Huy Trinh, Katherine E Ankenbauer, Sabrina M Torbit, Christopher P Taranto, Jiayue Liu, Ken S Lau

Cell Rep· December 2025

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Coordinated changes in stromal and hematopoietic cells that define the perinatal to juvenile transition in the mouse thymus.
Anusha Vasudev, Colin R Moore, Aparna Calindi, Seung Woo Kang, Bryan R Helm, Ken S Lau, Laura P Hale, Lauren I R Ehrlich

Cell Rep· December 2025

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Histology-Based Virtual RNA Inference Identifies Pathways Associated With Metastasis Risk in Colorectal Cancer.
Gokul Srinivasan, Minh-Khang Le, Zarif Azher, Xiaoying Liu, Louis Vaickus, Laurent Perreard, Ken S Lau

Mod Pathol· November 2025

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Cellular senescence in precancer lesions and early-stage cancers.
Xen Ping Hoi, Mary M Stangis, Sarah E Glass, Jin-Hee Kim, Seung Woo Kang, Ken S Lau

Cancer Cell· November 2025

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Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling.
Sara Alonso, Harsimran Kaur, Luo Jia, Mai-Uyen Nguyen, Alyssa Laguerta, Ken S Lau

Mucosal Immunol· October 2025

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Integration of elemental imaging and spatial transcriptomic profiling for proof-of-concept metals-based pathway analysis of colon tumor microenvironment.
Aruesha Srivastava, Neha Shaik, Yunrui Lu, Matthew Chan, Alos Diallo, Ken Lau, Laurent Perreard

Metallomics· October 2025

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Enhancing Clinical Data Management Through Barcode Integration and Research Electronic Data Capture: Scalable and Adaptable Implementation Study.
Rendong Zhang, Sophie Chiron, Regina Tyree, Kate Carson, Larry Raber, Ken S Lau

JMIR Form Res· September 2025

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Multi-ancestry genome-wide and transcriptome-wide association analyses identified new risk loci and genes for inflammatory bowel disease.
Linshuoshuo Lyu, Qing Li, Chao Li, Ghadeer K Dawwas, You Chen, Ken S Lau

medRxiv· September 2025

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3D collagen high-throughput screen identifies drugs that induce epithelial polarity and enhance chemotherapy response in colorectal cancer.
Sarah J Harmych, Thomas P Hasaka, Chelsie K Sievers, Seung Woo Kang, Marisol A Ramirez, Claudia C Wahoski, Ken S Lau

Commun Biol· August 2025

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Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors.
Monica E Brown, Verda E Miranda, Simone Nevills, Ruiying Hu, Prasanna K Dadi, Ken S Lau

Nat Commun· July 2025

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PoweREST: Statistical power estimation for spatial transcriptomics experiments to detect differentially expressed genes between two conditions.
Lan Shui, Anirban Maitra, Ying Yuan, Ken Lau, Harsimran Kaur

PLoS Comput Biol· July 2025

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Larger Neural Responses to Reward in Gambling Disorder: Relationships With Depression and Gambling Severity.
Maria Kryza-Lacombe, Samantha V Abram, Marc N Potenza, R Scott Mackin, Ken J Lau

Biol Psychiatry Cogn Neurosci Neuroimaging· July 2025

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Unbiased recording of clonal potency reveals species-specific regulation of mammalian intestine.
Mirazul Islam, Matthew E Bechard, Yilin Yang, Alan J Simmons, Yanwen Xu, Ken S Lau

bioRxiv· June 2025

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Dipeptidase-1-knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer.
Sarah E Glass, Matthew E Bechard, Zheng Cao, Radhika Aramandla, Ping Zhao, Ken S Lau

JCI Insight· May 2025

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Induced Neural Progenitor Specification from Human Pluripotent Stem Cells by a Refined Synthetic Notch Platform.
Catherine A Hamann, Andrew Kjar, Hyosung Kim, Alan J Simmons, Hannah J Brien, Ken S Lau

ACS Synth Biol· May 2025

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Temporally discordant chromatin accessibility and DNA demethylation define short- and long-term enhancer regulation during cell fate specification.
Lindsey N Guerin, Timothy J Scott, Jacqueline A Yap, Annelie Johansson, Fabio Puddu, Ken S Lau

Cell Rep· May 2025

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Deregulated Myt3 translation predisposes islet β-cells to dysfunction under obesity-induced metabolic stress.
Ruiying Hu, Yu Wang, Mahircan Yagan, Yanwen Xu, Alan J Simmons, Ken S Lau

bioRxiv· May 2025

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Insulin-like growth factor 2 as a driving force for exponential expansion and differentiation of the neonatal thymus.
Seung Woo Kang, Bryan R Helm, Yu Wang, Shiyun Xiao, Wen Zhang, Ken S Lau, Laura P Hale

Development· April 2025

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Pcdh20 is a POU2F3 target gene required for proper tuft cell microvillus formation.
Katherine E Ankenbauer, Yilin Yang, Chi-Yeh Chung, Leonardo R Andrade, Sammy Weiser Novak, Ken Lau

bioRxiv· April 2025

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Histology-Based Virtual RNA Inference Identifies Pathways Associated with Metastasis Risk in Colorectal Cancer.
Gokul Srinivasan, Minh-Khang Le, Zarif Azher, Xiaoying Liu, Louis Vaickus, Laurent Perreard, Ken S Lau

medRxiv· April 2025

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Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling.
Sara Alonso, Harsimran Kaur, Luo Jia, Mai-Uyen Nguyen, Alyssa Laguerta, Ken S Lau

bioRxiv· March 2025

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Identifying Cellular Neighborhood Phenotypes Differentiating Normal and Quiescent Crohn's Disease via MxIF.
Gaurav Rudravaram, Shunxing Bao, Aravind R Krishnan, Lucas W Remedios, Michael E Kim, Ken S Lau

Proc SPIE Int Soc Opt Eng· February 2025

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Quantitative Analysis of Colonic Epithelial Cell Aging in a Cell-cycle like Model: Changes in Nucleus and Cytoplasm Along the Crypt Axis.
Shunxing Bao, Yaohong Wang, Gaurav Rudravaram, Rendong Zhang, Ruining Deng, Ken S Lau

Proc SPIE Int Soc Opt Eng· February 2025

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