Publications by authors named "Keng G Lim"

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KDM6B Counteracts EZH2-Mediated Suppression of to Confer Resistance to PI3K/AKT Inhibitor Treatment in Breast Cancer.
Wenyu Wang, Keng Gat Lim, Min Feng, Yi Bao, Puay Leng Lee

Mol Cancer Ther· September 2018

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Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist.
Renukadevi Patil, Erzsébet Szabó, James I Fells, Andrea Balogh, Keng G Lim

Chem Biol· February 2015

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Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease.
Keng Gat Lim, Alexander I Gray, Nahoum G Anthony, Simon P Mackay, Susan Pyne

Arch Toxicol· December 2014

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Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor.
Renukadevi Patil, James I Fells, Erzsébet Szabó, Keng G Lim, Derek D Norman

J Med Chem· August 2014

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Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
James I Fells, Sue Chin Lee, Yuko Fujiwara, Derek D Norman, Keng Gat Lim

Mol Pharmacol· September 2013

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Regulation of interleukin-6 secretion by the two-pore-domain potassium channel Trek-1 in alveolar epithelial cells.
Andreas Schwingshackl, Bin Teng, Manik Ghosh, Keng Gat Lim, Gabor Tigyi

Am J Physiol Lung Cell Mol Physiol· February 2013

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Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions.
Gyöngyi N Kiss, James I Fells, Renuka Gupte, Sue-Chin Lee, Jianxiong Liu, Keng G Lim

Mol Pharmacol· December 2012

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Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b.
Keng Gat Lim, Francesca Tonelli, Evgeny Berdyshev, Irina Gorshkova, Tamara Leclercq

Int J Biochem Cell Biol· September 2012

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Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival.
Keng Gat Lim, Alexander I Gray, Susan Pyne, Nigel J Pyne

Br J Pharmacol· July 2012

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Sphingosine 1-phosphate signalling in cancer.
Nigel J Pyne, Francesca Tonelli, Keng Gat Lim, Jaclyn S Long, Joanne Edwards

Biochem Soc Trans· February 2012

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Targeting sphingosine kinase 1 in cancer.
Nigel J Pyne, Francesca Tonelli, Keng Gat Lim, Jaclyn Long, Joanne Edwards

Adv Biol Regul· January 2012

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(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.
Keng Gat Lim, Chaode Sun, Robert Bittman, Nigel J Pyne, Susan Pyne

Cell Signal· October 2011

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FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells.
Keng G Lim, Francesca Tonelli, Zaiguo Li, Xuequan Lu, Robert Bittman

J Biol Chem· May 2011

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The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells.
Carolyn Loveridge, Francesca Tonelli, Tamara Leclercq, Keng Gat Lim, Jaclyn S Long

J Biol Chem· December 2010

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FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Francesca Tonelli, Keng Gat Lim, Carolyn Loveridge, Jaclyn Long, Stuart M Pitson

Cell Signal· October 2010

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Optimization of microfluidic fuel cells using transport principles.
Jinkee Lee, Keng Guan Lim, G Tayhas R Palmore, Anubhav Tripathi

Anal Chem· October 2007

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Microfluidic biofuel cells: the influence of electrode diffusion layer on performance.
Keng Guan Lim, G Tayhas R Palmore

Biosens Bioelectron· January 2007

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