Publications by authors named "Kenneth A Howard"

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ADAMTS5-specific gapmer release from an albumin biomolecular assembly and cartilage internalization triggered by ultrasound.
Marwa Elkhashab, Goncalo Barreto, Maxime Fauconnier, Yohann Le Bourlout, Laura B Creemers, Kenneth A Howard

Drug Deliv· December 2025

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The interaction of PD-1/PD-L1 and its inhibition by anti-PD-L1 antibody at the single-molecule level.
Yonghui Zhang, Diego Pilati, Mingdong Dong, Kenneth A Howard

FEBS Lett· December 2025

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Exploiting FcRn engagement of an albumin-CpG oligonucleotide covalent conjugate for potent TLR9 immune induction.
Diego Pilati, Eugene Kusi Agyei, Marwa Elkhashab, Elisabeth Fuchs, Ian Helstrup Nielsen, Kenneth A Howard

J Biol Chem· June 2025

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Effective cancer immunotherapy combining mRNA-encoded bispecific antibodies that induce polyclonal T cell engagement and PD-L1-dependent 4-1BB costimulation.
Oana Hangiu, Rocío Navarro, Susana Frago, Laura Rubio-Pérez, Antonio Tapia-Galisteo, Kenneth A Howard

Front Immunol· May 2025

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An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models.
Aina Karen Anthi, Anette Kolderup, Eline Benno Vaage, Malin Bern, Sopisa Benjakul, Kenneth A Howard

Nat Commun· May 2025

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A Modular Albumin-Oligonucleotide Biomolecular Assembly for Delivery of Antisense Therapeutics.
Marwa Elkhashab, Yeter Dilek, Morten Foss, Laura B Creemers, Kenneth A Howard

Mol Pharm· February 2024

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An Albumin-Holliday Junction Biomolecular Modular Design for Programmable Multifunctionality and Prolonged Circulation.
Anders Dinesen, Veronica L Andersen, Marwa Elkhashab, Diego Pilati, Pernille Bech, Kenneth A Howard

Bioconjug Chem· February 2024

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Identification of a high-risk immunogenic prostate cancer patient subset as candidates for T-cell engager immunotherapy and the introduction of a novel albumin-fused anti-CD3 × anti-PSMA bispecific design.
Eske N Glud, Martin Rasmussen, Yonghui Zhang, Ole A Mandrup, Paul Vinu Salachan, Kenneth A Howard

Br J Cancer· December 2022

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An albumin-angiotensin converting enzyme 2-based SARS-CoV-2 decoy with FcRn-driven half-life extension.
Elisabeth Fuchs, Imke Rudnik-Jansen, Anders Dinesen, Denis Selnihhin, Ole Aalund Mandrup, Kenneth A Howard

Acta Biomater· November 2022

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Tumor targeted 4-1BB agonist antibody-albumin fusions with high affinity to FcRn induce anti-tumor immunity without toxicity.
Oana Hangiu, Marta Compte, Anders Dinesen, Rocio Navarro, Antonio Tapia-Galisteo, Kenneth A Howard

iScience· September 2022

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Functionalized Acyclic (l)-Threoninol Nucleic Acid Four-Way Junction with High Stability In Vitro and In Vivo.
Anders Märcher, Vipin Kumar, Veronica L Andersen, Kassem El-Chami, Thuy J D Nguyen, Kenneth A Howard

Angew Chem Int Ed Engl· June 2022

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Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis.
Rebecca A Symons, Fabio Colella, Fraser L Collins, Alexandra J Rafipay, Karolina Kania, Kenneth A Howard

Ann Rheum Dis· February 2022

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Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly.
Anders Dinesen, Alexander Winther, Archie Wall, Anders Märcher, Johan Palmfeldt, Kenneth A Howard

Bioconjug Chem· February 2022

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FcRn expression in cancer: Mechanistic basis and therapeutic opportunities.
Imke Rudnik-Jansen, Kenneth A Howard

J Control Release· September 2021

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Per-glycosylation of the Surface-Accessible Lysines: One-Pot Aqueous Route to Stabilized Proteins with Native Activity.
Raoul Walther, Pere Monge, Andreas Bøtker Pedersen, Anja Benderoth, Jannik Nedergaard Pedersen, Kenneth A Howard

Chembiochem· July 2021

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Bioengineered solutions to improve cancer immunotherapies.
Ole A Mandrup, Kenneth A Howard

Ther Deliv· May 2021

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Albumin-Binding Fatty Acid-Modified Gapmer Antisense Oligonucleotides for Modulation of Pharmacokinetics.
Yunpeng Cai, Chenguang Lou, Jesper Wengel, Kenneth A Howard

Methods Mol Biol· March 2021

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Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity.
Ole A Mandrup, Sui Ching Ong, Simon Lykkemark, Anders Dinesen, Imke Rudnik-Jansen, Kenneth A Howard

Commun Biol· March 2021

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Roadmap on nanomedicine.
Paolo Decuzzi, Dan Peer, Daniele Di Mascolo, Anna Lisa Palange, Purnima Naresh Manghnani, Kenneth A Howard

Nanotechnology· January 2021

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Albumin-based drug designs for pharmacokinetic modulation.
Diego Pilati, Kenneth A Howard

Expert Opin Drug Metab Toxicol· September 2020

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FcRn overexpression in human cancer drives albumin recycling and cell growth; a mechanistic basis for exploitation in targeted albumin-drug designs.
Maja Thim Larsen, Ole A Mandrup, Karen Kræmmer Schelde, Yonglun Luo, Karina Dalsgaard Sørensen, Kenneth A Howard

J Control Release· June 2020

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Size-Selective Phagocytic Clearance of Fibrillar α-Synuclein through Conformational Activation of Complement Receptor 4.
Kristian Juul-Madsen, Per Qvist, Kirstine L Bendtsen, Annette E Langkilde, Bente Vestergaard, Kenneth A Howard

J Immunol· March 2020

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Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis.
Karolina Kania, Fabio Colella, Anna H K Riemen, Hui Wang, Kenneth A Howard

Sci Rep· January 2020

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Optimised approach to albumin-drug conjugates using monobromomaleimide-C-2 linkers.
Archie Wall, Karl Nicholls, Mikael B Caspersen, Stig Skrivergaard, Kenneth A Howard

Org Biomol Chem· August 2019

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Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling.
Ramya Nandakumar, Roland Tschismarov, Felix Meissner, Thaneas Prabakaran, Abhichart Krissanaprasit, Kenneth A Howard

Nat Microbiol· April 2019

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