Publications by authors named "Kenneth Botkjaer"

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Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis.
Kazuhiro Yamamoto, Salvatore Santamaria, Kenneth A Botkjaer, Jayesh Dudhia, Linda Troeberg

Arthritis Rheumatol· June 2017

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Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo.
Kenneth A Botkjaer, Hang Fai Kwok, Mikkel G Terp, Aneesh Karatt-Vellatt, Salvatore Santamaria

Oncotarget· March 2016

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Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites.
Daniel M Dupont, Cathrine K Thuesen, Kenneth A Bøtkjær, Manja A Behrens, Karen Dam

PLoS One· February 2016

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Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2).
Salvatore Santamaria, Kazuhiro Yamamoto, Kenneth Botkjaer, Christopher Tape, Michael R Dyson

Biochem J· November 2015

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Tissue-type plasminogen activator-binding RNA aptamers inhibiting low-density lipoprotein receptor family-mediated internalisation.
Nils Bjerregaard, Kenneth A Bøtkjær, Nicky Helsen, Peter A Andreasen, Daniel M Dupont

Thromb Haemost· July 2015

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Development of a 'mouse and human cross-reactive' affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy.
Hang Fai Kwok, Kenneth A Botkjaer, Christopher J Tape, Yanchao Huang, John McCafferty

Protein Eng Des Sel· June 2014

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Rezymogenation of active urokinase induced by an inhibitory antibody.
Longguang Jiang, Kenneth A Botkjaer, Lisbeth M Andersen, Cai Yuan, Peter A Andreasen

Biochem J· January 2013

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Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism.
Kenneth A Botkjaer, Elena I Deryugina, Daniel M Dupont, Henrik Gårdsvoll, Erin M Bekes

Mol Cancer Res· December 2012

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Activation of pro-uPA is critical for initial escape from the primary tumor and hematogenous dissemination of human carcinoma cells.
Erin M Bekes, Elena I Deryugina, Tatyana A Kupriyanova, Ewa Zajac, Kenneth A Botkjaer

Neoplasia· September 2011

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Targeting the autolysis loop of urokinase-type plasminogen activator with conformation-specific monoclonal antibodies.
Kenneth A Botkjaer, Sarah Fogh, Erin C Bekes, Zhuo Chen, Grant E Blouse

Biochem J· August 2011

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Activation of the zymogen to urokinase-type plasminogen activator is associated with increased interdomain flexibility.
Manja A Behrens, Kenneth A Botkjaer, Sumit Goswami, Cristiano L P Oliveira, Jan K Jensen

J Mol Biol· August 2011

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Nonproteolytic induction of catalytic activity into the single-chain form of urokinase-type plasminogen activator by dipeptides.
Kenneth A Bøtkjaer, Aleksandra A Byszuk, Lisbeth M Andersen, Anni Christensen, Peter A Andreasen

Biochemistry· October 2009

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Comparative analysis of metastasis variants derived from human prostate carcinoma cells: roles in intravasation of VEGF-mediated angiogenesis and uPA-mediated invasion.
Erin M Conn, Kenneth A Botkjaer, Tatyana A Kupriyanova, Peter A Andreasen, Elena I Deryugina

Am J Pathol· October 2009

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A novel mode of intervention with serine protease activity: targeting zymogen activation.
Grant E Blouse, Kenneth A Bøtkjaer, Elena Deryugina, Aleksandra A Byszuk, Janni M Jensen

J Biol Chem· February 2009

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