Publications by authors named "Kenneth Cassidy"

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Guided Sample Pooling in Human Mass Balance Studies: A Recommended Strategic Decision Framework.
Filip Cuyckens, Wenying Li, Adam M Auclair, Kenneth C Cassidy, Cathy Cantalloube

Clin Pharmacol Ther· December 2025

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Disposition and Absolute Bioavailability of Oral Imlunestrant in Healthy Women: A Phase 1, Open-Label Study.
Amita Datta-Mannan, Boris Czeskis, Elaine Shanks, Eunice Yuen, Stephen Hall, Kenneth Cassidy

Clin Pharmacol Drug Dev· October 2025

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Disposition and Absolute Bioavailability of Orally Administered Orforglipron in Healthy Participants.
Bridget L Morse, Shobha Bhattachar, Xiaosu Ma, David E Coutant, Boris Czeskis, Kenneth C Cassidy

Clin Pharmacol Drug Dev· September 2025

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Absorption, distribution, metabolism, and excretion of tirzepatide in humans, rats, and monkeys.
Jennifer A Martin, Boris Czeskis, Shweta Urva, Kenneth C Cassidy

Eur J Pharm Sci· November 2024

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Non-Labeled, Stable Labeled, or Radiolabelled Approaches for Provision of Intravenous Pharmacokinetics in Humans: A Discussion Piece.
Graeme C Young, Douglas K Spracklin, Alexander D James, Mette G Hvenegaard, Mette L Pedersen, Kenneth C Cassidy

Clin Pharmacol Ther· May 2024

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Recommendations on the Use of Multiple Labels in Human Mass Balance Studies.
Filip Cuyckens, Mette G Hvenegaard, Kenneth C Cassidy, Douglas K Spracklin, Alexander D James

Drug Metab Dispos· February 2024

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Considerations for Human ADME Strategy and Design Paradigm Shift(s) - An Industry White Paper.
Graeme C Young, Douglas K Spracklin, Alexander D James, Mette G Hvenegaard, Graeme Scarfe, Kenneth C Cassidy

Clin Pharmacol Ther· April 2023

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Excretion, Mass Balance, and Metabolism of [C]LY3202626 in Humans: An Interplay of Microbial Reduction, Reabsorption, and Aldehyde Oxidase Oxidation That Leads to an Extended Excretion Profile.
Kishore Katyayan, Ping Yi, Scott Monk, Kenneth Cassidy

Drug Metab Dispos· August 2020

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Disposition of [C]LY2606368 following intravenous administration in patients with advanced and/or metastatic solid tumours.
Enaksha R Wickremsinhe, Scott M Hynes, Christopher D Payne, Yingying Guo, Kenneth C Cassidy

Xenobiotica· July 2020

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Enterohepatic circulation of glucuronide metabolites of drugs in dog.
Xin Zhou, Kenneth C Cassidy, Loyd Hudson, Michael A Mohutsky, Geri A Sawada

Pharmacol Res Perspect· August 2019

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Qualitative and quantitative prediction of human in vivo metabolic pathways in a human hepatocyte-murine stromal cell co-culture model.
Kenneth C Cassidy, Ping Yi

Xenobiotica· December 2018

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Disposition and metabolism of [C]-galunisertib, a TGF-βRI kinase/ALK5 inhibitor, following oral administration in healthy subjects and mechanistic prediction of the effect of itraconazole on galunisertib pharmacokinetics.
Kenneth C Cassidy, Ivelina Gueorguieva, Colin Miles, Jessica Rehmel, Ping Yi

Xenobiotica· April 2018

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Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury.
Bryan H Norman, Matthew J Fisher, Matthew A Schiffler, Steven L Kuklish, Norman E Hughes, Kenneth C Cassidy

J Med Chem· March 2018

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Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats.
Xin Zhou, Luc R A Rougée, David W Bedwell, Jeff W Cramer, Michael A Mohutsky, Kenneth C Cassidy

Drug Metab Dispos· August 2016

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Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.
Prabhakar K Jadhav, Matthew A Schiffler, Kostas Gavardinas, Euibong J Kim, Donald P Matthews, Kenneth C Cassidy

ACS Med Chem Lett· October 2014

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Disposition and metabolism of LY2603618, a Chk-1 inhibitor following intravenous administration in patients with advanced and/or metastatic solid tumors.
Enaksha R Wickremsinhe, Scott M Hynes, Margo D Palmieri, Malcolm I Mitchell, Trent L Abraham, Kenneth C Cassidy

Xenobiotica· September 2014

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Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure.
Maciej J Zamek-Gliszczynski, Trent L Abraham, Jeffrey J Alberts, Palaniappan Kulanthaivel, Kimberley A Jackson, Kenneth C Cassidy

Drug Metab Dispos· April 2013

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Disposition and metabolism of LY2452473, a selective androgen receptor modulator, in humans.
Ping Yi, Jessica Fayer Rehmel, Kenneth Cassidy, Chad Hadden, Kristina Campanale

Drug Metab Dispos· December 2012

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