Publications by authors named "Kenneth Hull"

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Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic ductal adenocarcinoma.
Maryam Safari, Luigi Scotto, Agnes Basseville, Thomas Litman, Haoran Xue, Kenneth G Hull

Drug Resist Updat· January 2026

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Antioxidant, anti-tyrosinase, hepatoprotective, and anti-inflammatory potential in flowers and seeds of (Lour.) Merr.
Hien Minh Nguyen, Khanh Phuc Nguyen, An Thuy Pham Le, Nguyen Huong Thi Nguyen, Long Kim Vu-Huynh, Kenneth Hull

Nat Prod Res· November 2025

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Intramolecular epistasis correlates with divergence of specificity in promiscuous and bifunctional NSAR/OSBS enzymes.
Dat P Truong, Roopa Dharmatti, Dylan Suriadinata, Jamison Huddleston, Rebecca Skouby, Kenneth G Hull

Protein Sci· May 2025

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Combined HDAC and eIF4A inhibition: A novel epigenetic therapy for pancreatic adenocarcinoma.
Maryam Safari, Luigi Scotto, Agnes Basseville, Thomas Litman, Haoran Xue, Kenneth Hull

bioRxiv· July 2024

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TRPM7 in neurodevelopment and therapeutic prospects for neurodegenerative disease.
Zhengwei Luo, Xinyang Zhang, Andrea Fleig, Daniel Romo, Kenneth G Hull

Cell Calcium· June 2024

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Dopamine-Derived Guanidine Alkaloids from a Didemnidae Tunicate: Isolation, Synthesis, and Biological Activities.
Ryuichi Sakai, Ken Matsumura, Hajime Uchimasu, Kei Miyako, Tohru Taniguchi, Kenneth G Hull

J Org Chem· May 2024

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Transient Receptor Potential Melastatin 7 (TRPM7) Ion Channel Inhibitors: Preliminary SAR and Conformational Studies of Xenicane Diterpenoids from the Hawaiian Soft Coral .
Guangmin Yao, Matthew R Parris, W Cedric Kuo, Peter Pörzgen, Brandi Castillo, Kenneth G Hull

J Nat Prod· April 2024

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Spatial organization and function of RNA molecules within phase-separated condensates in zebrafish are controlled by Dnd1.
Kim Joana Westerich, Katsiaryna Tarbashevich, Jan Schick, Antra Gupta, Mingzhao Zhu, Kenneth Hull

Dev Cell· September 2023

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Spatial organization and function of RNA molecules within phase-separated condensates are controlled by Dnd1.
Kim Joana Westerich, Katsiaryna Tarbashevich, Jan Schick, Antra Gupta, Mingzhao Zhu, Kenneth Hull

bioRxiv· July 2023

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Second-Shell Amino Acid R266 Helps Determine -Succinylamino Acid Racemase Reaction Specificity in Promiscuous -Succinylamino Acid Racemase/-Succinylbenzoate Synthase Enzymes.
Dat P Truong, Simon Rousseau, Benjamin W Machala, Jamison P Huddleston, Mingzhao Zhu, Kenneth G Hull

Biochemistry· December 2021

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Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A.
Sai Kiran Naineni, Jason Liang, Kenneth Hull, Regina Cencic, Mingzhao Zhu

Cell Chem Biol· June 2021

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Waixenicin A, a marine-derived TRPM7 inhibitor: a promising CNS drug lead.
Hong-Shuo Sun, F David Horgen, Daniel Romo, Kenneth G Hull, Sigrid A Kiledal

Acta Pharmacol Sin· December 2020

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Secreted Protein-2 (-ASP-2) Binds an Ascaroside (ascr#3) in Its Fatty Acid Binding Site.
Ola El Atab, Rabih Darwiche, Nathanyal J Truax, Roger Schneiter, Kenneth G Hull

Front Chem· December 2020

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Synthetic Tigliane Intermediates Engage Thiols to Induce Potent Cell Line Selective Anti-Cancer Activity.
Sharon Chow, Tanja Krainz, Christian J Bettencourt, Natasa Broit, Blake Ferguson, Kenneth G Hull

Chemistry· October 2020

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Molecular Mechanism for Attractant Signaling to DHMA by E. coli Tsr.
Asuka A Orr, Jingyun Yang, Nitesh Sule, Ravi Chawla, Kenneth G Hull

Biophys J· January 2020

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Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia.
Rong Chen, Mingzhao Zhu, Rajan R Chaudhari, Omar Robles, Yuling Chen, Kenneth G Hull

Leukemia· July 2019

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A Novel Actin Binding Drug with Efficacy.
Akshaya Ravichandran, Mengxin Geng, Kenneth G Hull, Jing Li, Daniel Romo

Antimicrob Agents Chemother· January 2019

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Comparison of Alicyclobacillus acidocaldarius o-Succinylbenzoate Synthase to Its Promiscuous N-Succinylamino Acid Racemase/ o-Succinylbenzoate Synthase Relatives.
Denis Odokonyero, Andrew W McMillan, Udupi A Ramagopal, Rafael Toro, Dat P Truong, Kenneth G Hull

Biochemistry· July 2018

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Bioactive Seco-Lanostane-Type Triterpenoids from the Roots of Leplaea mayombensis.
Lazare S Sidjui, Kenneth O Eyong, Kenneth G Hull, Gabriel N Folefoc, Valérie M Leddet

J Nat Prod· October 2017

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A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.
Mingzhao Zhu, Wayne D Harshbarger, Omar Robles, Joanna Krysiak, Kenneth G Hull

Bioorg Med Chem· June 2017

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Chemical Mechanism of the Phosphotriesterase from Sphingobium sp. Strain TCM1, an Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants.
Andrew N Bigley, Dao Feng Xiang, Zhongjie Ren, Haoran Xue, Kenneth G Hull

J Am Chem Soc· March 2016

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Interrogation of the Substrate Profile and Catalytic Properties of the Phosphotriesterase from Sphingobium sp. Strain TCM1: An Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants and Plasticizers.
Dao Feng Xiang, Andrew N Bigley, Zhongjie Ren, Haoran Xue, Kenneth G Hull

Biochemistry· December 2015

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Novel topoisomerase inhibitors: microbiological characterisation and in vivo efficacy of pyrimidines.
Maria Uria-Nickelsen, Georg Neckermann, Shubha Sriram, Beth Andrews, John I Manchester, Kenneth G Hull

Int J Antimicrob Agents· April 2013

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Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV.
John I Manchester, Daemian D Dussault, Jonathan A Rose, P Ann Boriack-Sjodin, Maria Uria-Nickelsen, Kenneth G Hull

Bioorg Med Chem Lett· August 2012

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Pyrrolamide DNA gyrase inhibitors: optimization of antibacterial activity and efficacy.
Brian A Sherer, Kenneth Hull, Oluyinka Green, Gregory Basarab, Sheila Hauck

Bioorg Med Chem Lett· December 2011

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