Publications by authors named "Gregory Basarab"

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Negamycin: Nature's Forgotten Antibiotic.
Grant A Boyle, Gregory S Basarab

ACS Infect Dis· December 2025

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Optimization of 2,8-Diaryl-1,5-naphthyridines as Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy.
Godwin A Dziwornu, Donald Seanego, Stephen Fienberg, Venkata S Sypu, Nicolaas Salomane, Gregory S Basarab

J Med Chem· October 2025

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Cell-Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds with Diverging Parasitological Profiles against the Human Malaria Parasite .
Jean Dam, Grant A Boyle, André Horatscheck, John G Woodland, Claire Le Manach, Gregory S Basarab

J Med Chem· May 2025

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Design of Novel Mercapto-3-phenylpropanoyl Dipeptides as Dual Angiotensin-Converting Enzyme C-Domain-Selective/Neprilysin Inhibitors.
Gyles E Cozier, Lauren B Coulson, Charles J Eyermann, Gregory S Basarab, Sylva L Schwager

J Med Chem· April 2025

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Dose-fractionation studies of a phosphatidylinositol 4-kinase inhibitor in a humanized mouse model of malaria.
Liezl Gibhard, Mathew Njoroge, Mwila Mulubwa, Nina Lawrence, Dennis Smith, Gregory S Basarab

Antimicrob Agents Chemother· October 2024

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Interactions between Zoliflodacin and Gyrase and Topoisomerase IV: Enzymological Basis for Cellular Targeting.
Jessica A Collins, Gregory S Basarab, Kelly Chibale, Neil Osheroff

ACS Infect Dis· August 2024

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2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Phosphatidylinositol-4-kinase and Hemozoin Formation with Efficacy.
Godwin Akpeko Dziwornu, Donald Seanego, Stephen Fienberg, Monica Clements, Jasmin Ferreira, Gregory S Basarab

J Med Chem· July 2024

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Anti-infectives Developed as Racemic Drugs in the 21st Century: Norm or Exception?
Diego González Cabrera, Dennis A Smith, Gregory S Basarab, James Duffy, Thomas Spangenberg

ACS Med Chem Lett· July 2023

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A Water-Soluble Polymer-Lumefantrine Conjugate for the Intravenous Treatment of Severe Malaria.
William M R Matshe, Lesego L Tshweu, Sindisiwe Mvango, Zamani E D Cele, Avashnee S Chetty, Gregory S Basarab

Macromol Biosci· May 2023

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The 2022 H3D Symposium: Celebrating over a Decade of African-Led Infectious Disease Drug Discovery to Enhance Global Health.
John G Woodland, Gregory S Basarab, Koketso Mogwera, Susan Winks, Kelly Chibale

ACS Infect Dis· March 2023

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A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Gyrase.
Jo Ann W Byl, Rudolf Mueller, Ben Bax, Gregory S Basarab, Kelly Chibale

ACS Infect Dis· March 2023

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Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.
Preshendren Govender, Rudolf Müller, Kawaljit Singh, Virsinha Reddy, Charles J Eyermann, Gregory S Basarab

J Med Chem· May 2022

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Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones.
Gregory S Basarab, Sandeep Ghorpade, Liezl Gibhard, Rudolf Mueller, Mathew Njoroge

Antimicrob Agents Chemother· April 2022

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Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition.
Lauren B Arendse, Gyles E Cozier, Charles J Eyermann, Gregory S Basarab, Sylva L Schwager

J Med Chem· February 2022

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1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in .
Lutete Peguy Khonde, Rudolf Müller, Grant A Boyle, Virsinha Reddy, Aloysius T Nchinda, Gregory S Basarab

J Med Chem· September 2021

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Correction to "Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and Efficacy in the NSG Mouse Model".
André Horatscheck, Ana Andrijevic, Aloysius T Nchinda, Claire Le Manach, Tanya Paquet, Gregory S Basarab

J Med Chem· February 2021

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Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite and Optimization Efforts.
Claire Le Manach, Jean Dam, John G Woodland, Gurminder Kaur, Lutete P Khonde, Gregory S Basarab

J Med Chem· February 2021

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Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.
Candice Soares de Melo, Vinayak Singh, Alissa Myrick, Sandile B Simelane, Dale Taylor, Gregory S Basarab

J Med Chem· January 2021

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Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box.
Janette Reader, Mariëtte E van der Watt, Dale Taylor, Claire Le Manach, Nimisha Mittal, Gregory Basarab

Nat Commun· January 2021

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Structural Basis for Inhibitor Potency and Selectivity of Phosphatidylinositol 4-Kinase Inhibitors.
Stephen Fienberg, Charles J Eyermann, Lauren B Arendse, Gregory S Basarab, Jacob A McPhail

ACS Infect Dis· November 2020

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Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and Efficacy in the NSG Mouse Model.
André Horatscheck, Ana Andrijevic, Aloysius T Nchinda, Claire Le Manach, Tanya Paquet, Gregory S Basarab

J Med Chem· November 2020

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Antibacterial Spiropyrimidinetriones with N-Linked Azole Substituents on a Benzisoxazole Scaffold Targeting DNA Gyrase.
Gregory S Basarab, Peter Doig, Charles J Eyermann, Vincent Galullo, Gunther Kern

J Med Chem· October 2020

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Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.
Liezl Gibhard, Mathew Njoroge, Tanya Paquet, Christel Brunschwig, Dale Taylor, Gregory S Basarab

Antimicrob Agents Chemother· December 2018

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Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Christel Brunschwig, Nina Lawrence, Dale Taylor, Efrem Abay, Mathew Njoroge, Gregory S Basarab

Antimicrob Agents Chemother· November 2018

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Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.
Claire Le Manach, Tanya Paquet, Kathryn Wicht, Aloysius T Nchinda, Christel Brunschwig, Gregory S Basarab

J Med Chem· October 2018

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