Publications by authors named "Kenneth T Macleod"

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Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells.
Nicola Dark, Marie-Victoire Cosson, Lorenza I Tsansizi, Thomas J Owen, Elisa Ferraro, Kenneth T MacLeod

Cell Rep Methods· April 2023

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Changes in cellular Ca and Na regulation during the progression towards heart failure.
Kenneth T MacLeod

J Physiol· March 2023

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High-speed 2D light-sheet fluorescence microscopy enables quantification of spatially varying calcium dynamics in ventricular cardiomyocytes.
Liuba Dvinskikh, Hugh Sparks, Kenneth T MacLeod, Chris Dunsby

Front Physiol· February 2023

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GPER limits adverse changes to Ca signalling and arrhythmogenic activity in ovariectomised guinea pig cardiomyocytes.
Alice J Francis, Jahn M Firth, Jose L Sanchez-Alonso, Julia Gorelik, Kenneth T MacLeod

Front Physiol· November 2022

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Integrins Increase Sarcoplasmic Reticulum Activity for Excitation-Contraction Coupling in Human Stem Cell-Derived Cardiomyocytes.
Brian X Wang, Christopher Kane, Laura Nicastro, Oisín King, Worrapong Kit-Anan, Kenneth T MacLeod

Int J Mol Sci· September 2022

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Moving in the right direction: elucidating the mechanisms of interaction between flecainide and the cardiac ryanodine receptor.
Mark L Bannister, Kenneth T MacLeod, Christopher H George

Br J Pharmacol· June 2022

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OCT2013, an ischaemia-activated antiarrhythmic prodrug, devoid of the systemic side effects of lidocaine.
Louise M Hesketh, Markus B Sikkel, Laura Mahoney-Sanchez, Francesca Mazzacuva, Rasheda A Chowdhury, Kenneth T MacLeod

Br J Pharmacol· May 2022

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Extracellular Vesicles from Human Cardiac Fibroblasts Modulate Calcium Cycling in Human Stem Cell-Derived Cardiomyocytes.
Brian X Wang, Laura Nicastro, Liam Couch, Worrapong Kit-Anan, Barrett Downing, Kenneth T MacLeod

Cells· March 2022

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The Effect of Estrogen on Intracellular Ca and Na Regulation in Heart Failure.
Jahn M Firth, Hsiang-Yu Yang, Alice J Francis, Najah Islam, Kenneth T MacLeod

JACC Basic Transl Sci· September 2020

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Approaches to High-Throughput Analysis of Cardiomyocyte Contractility.
Peter T Wright, Sharmane F Tsui, Alice J Francis, Kenneth T MacLeod, Steven B Marston

Front Physiol· July 2020

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Age- and strain-related aberrant Ca release is associated with sudden cardiac death in the ACTC E99K mouse model of hypertrophic cardiomyopathy.
Christina T Rowlands, Thomas Owen, Saheed Lawal, Shuangyi Cao, Samata S Pandey, Kenneth T MacLeod

Am J Physiol Heart Circ Physiol· December 2017

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Hierarchical statistical techniques are necessary to draw reliable conclusions from analysis of isolated cardiomyocyte studies.
Markus B Sikkel, Darrel P Francis, James Howard, Fabiana Gordon, Christina Rowlands, Kenneth T MacLeod

Cardiovasc Res· December 2017

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Effect of ovariectomy on intracellular Ca regulation in guinea pig cardiomyocytes.
Hsiang-Yu Yang, Jahn M Firth, Alice J Francis, Anita Alvarez-Laviada, Kenneth T MacLeod

Am J Physiol Heart Circ Physiol· November 2017

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Restitution slope is principally determined by steady-state action potential duration.
Michael J Shattock, Kyung Chan Park, Hsiang-Yu Yang, Angela W C Lee, Steven Niederer, Kenneth T MacLeod

Cardiovasc Res· June 2017

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Erratum: High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes: [J. Biophotonics 9, No. 3, 311-323 (2016)].
Markus B Sikkel, Sunil Kumar, Vincent Maioli, Christina Rowlands, Fabiana Gordon, Kenneth T MacLeod

J Biophotonics· May 2017

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Functional consequences of co-expressing connexin40 or connexin45 with connexin43 on intercellular electrical coupling.
Neil M Thomas, Rosaire Gray, Christopher H Fry, Thomas Desplantez, Nicholas S Peters, Kenneth T Macleod

Biochem Biophys Res Commun· January 2017

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Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia.
Alan J Williams, Mark L Bannister, N Lowri Thomas, Markus B Sikkel, Saptarshi Mukherjee, Kenneth T MacLeod

J Physiol· November 2016

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A post-MI power struggle: adaptations in cardiac power occur at the sarcomere level alongside MyBP-C and RLC phosphorylation.
Christopher N Toepfer, Markus B Sikkel, Valentina Caorsi, Anupama Vydyanath, Iratxe Torre, Kenneth T Macleod

Am J Physiol Heart Circ Physiol· August 2016

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Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor.
Mark L Bannister, Anita Alvarez-Laviada, N Lowri Thomas, Sammy A Mason, Sharon Coleman, Kenneth T MacLeod

Br J Pharmacol· August 2016

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High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes.
Markus B Sikkel, Sunil Kumar, Vincent Maioli, Christina Rowlands, Fabiana Gordon, Kenneth T MacLeod

J Biophotonics· March 2016

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The mechanism of flecainide action in CPVT does not involve a direct effect on RyR2.
Mark L Bannister, N Lowri Thomas, Markus B Sikkel, Saptarshi Mukherjee, Chloe Maxwell, Kenneth T MacLeod

Circ Res· April 2015

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Characterisation of connexin expression and electrophysiological properties in stable clones of the HL-1 myocyte cell line.
Priyanthi Dias, Thomas Desplantez, Majd A El-Harasis, Rasheda A Chowdhury, Nina D Ullrich, Kenneth T MacLeod

PLoS One· October 2014

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Cardiac remodelling during pregnancy: whither the guinea pig?
Michael J Taggart, Richard Hume, Jon Lartey, Mark Johnson, Wing-Chiu Tong, Kenneth T Macleod

Cardiovasc Res· October 2014

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SERCA2a gene therapy in heart failure: an anti-arrhythmic positive inotrope.
Markus B Sikkel, Carl Hayward, Kenneth T MacLeod, Sian E Harding, Alexander R Lyon

Br J Pharmacol· January 2014

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Letter by Sikkel et al regarding article, "Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy".
Markus B Sikkel, Kenneth T MacLeod, Fabiana Gordon

Circulation· September 2013

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