Publications by authors named "Kenneth W Duncan"

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Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement.
Brian A Sparling, Hyelee Lee, Mary-Margaret Zablocki, Maureen M Lynes, Simina Grigoriu, Kenneth W Duncan

ACS Med Chem Lett· November 2025

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Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9.
Matthew H Daniels, Jennifer Castro, Young-Tae Lee, Deepali Gotur, Kevin E Knockenhauer, Kenneth W Duncan

J Med Chem· May 2025

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Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.
Gordon J Lockbaum, Maureen M Lynes, Sophie A Shen, Julie Liu, Nicholas Holt, Kenneth W Duncan

Commun Biol· April 2025

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A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair.
Jennifer Castro, Matthew H Daniels, David Brennan, Brian Johnston, Deepali Gotur, Kenneth W Duncan

Cancer Res· February 2025

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Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies.
Joshua S Alford, John W Lampe, Dorothy Brach, Richard Chesworth, Kat Cosmopoulos, Kenneth W Duncan

ACS Med Chem Lett· July 2022

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Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies.
John W Lampe, Joshua S Alford, P Ann Boriak-Sjodin, Dorothy Brach, Kat Cosmopoulos, Kenneth W Duncan

ACS Med Chem Lett· October 2021

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Identification of a peptide inhibitor for the histone methyltransferase WHSC1.
Michael J Morrison, P Ann Boriack-Sjodin, Kerren K Swinger, Tim J Wigle, Dipti Sadalge, Kenneth W Duncan

PLoS One· August 2018

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Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.
Allison E Drew, Oscar Moradei, Suzanne L Jacques, Nathalie Rioux, Ann P Boriack-Sjodin, Kenneth W Duncan

Sci Rep· December 2017

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Species differences in metabolism of EPZ015666, an oxetane-containing protein arginine methyltransferase-5 (PRMT5) inhibitor.
Nathalie Rioux, Kenneth W Duncan, Ronald J Lantz, Xiusheng Miao, Elayne Chan-Penebre

Xenobiotica· October 2016

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Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666.
Kenneth W Duncan, Nathalie Rioux, P Ann Boriack-Sjodin, Michael J Munchhof, Lawrence A Reiter

ACS Med Chem Lett· February 2016

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Metabolism and disposition of the DOT1L inhibitor, pinometostat (EPZ-5676), in rat, dog and human.
Nigel J Waters, Sherri A Smith, Edward J Olhava, Kenneth W Duncan, Richard D Burton

Cancer Chemother Pharmacol· January 2016

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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Elayne Chan-Penebre, Kristy G Kuplast, Christina R Majer, P Ann Boriack-Sjodin, Tim J Wigle, Kenneth W Duncan

Nat Chem Biol· June 2015

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Small molecule tyrosine kinase inhibitors for the treatment of intestinal inflammation.
Maninder Sidhu, Carmen Alonso Cotoner, Bayasi Guleng, Seiji Arihiro, Sunyoung Chang, Kenneth W Duncan

Inflamm Bowel Dis· December 2011

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