Publications by authors named "Kentaro Sahashi"

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Correcting tau isoform ratios with a long-acting antisense oligonucleotide alleviates 4R-tauopathy phenotypes.
Kuniyuki Iwata-Endo, Kentaro Sahashi, Kaori Kawai, Yusuke Fujioka, Yohei Okada

Mol Ther Nucleic Acids· June 2025

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Label-free morphology-based phenotypic analysis of spinal and bulbar muscular atrophy muscle cell models.
Kenji Sakakibara, Kenjiro Tanaka, Madoka Iida, Yuta Imai, Mai Okada, Kentaro Sahashi

Dis Model Mech· June 2025

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Dysregulated synaptic gene expression in oligodendrocytes of spinal and bulbar muscular atrophy.
Madoka Iida, Kentaro Sahashi, Tomoki Hirunagi, Kenji Sakakibara, Kentaro Maeda

JCI Insight· June 2025

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A case of severe immune-related adverse events, myocarditis with myositis, and myasthenia gravis overlap syndrome following adjuvant nivolumab administration for muscle-invasive bladder cancer.
Hiroki Kamikawa, Yoshihisa Matsukawa, Hisae Nishii, Yushi Naito, Kazuki Obara, Kentaro Sahashi

Nagoya J Med Sci· February 2025

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A rapid and easy-to-use spinal muscular atrophy screening tool based on primers with high specificity and amplification efficiency for SMN1 combined with single-stranded tag hybridization assay.
Masaki Hirano, Kentaro Sahashi, Yuki Ichikawa, Masahisa Katsuno, Atsushi Natsume

PLoS One· August 2024

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Exercise attenuates polyglutamine-mediated neuromuscular degeneration in a mouse model of spinal and bulbar muscular atrophy.
Tomoki Hirunagi, Hideaki Nakatsuji, Kentaro Sahashi, Mikiyasu Yamamoto, Madoka Iida

J Cachexia Sarcopenia Muscle· February 2024

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Clinicopathological features of graft versus host disease-associated myositis.
Tomoyuki Kazuta, Ayuka Murakami, Seiya Noda, Satoko Hirano, Hiroshi Kito, Kentaro Sahashi

Ann Clin Transl Neurol· February 2024

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Dysregulation of Aldh1a2 underlies motor neuron degeneration in spinal muscular atrophy.
Mayumi Kataoka, Kentaro Sahashi, Koyo Tsujikawa, Jun-Ichi Takeda, Tomoki Hirunagi

Neurosci Res· September 2023

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Neutrophil extracellular traps: from antimicrobial innate immunity to the development of chemotherapy-induced peripheral neuropathy.
Haruki Koike, Yohei Iguchi, Kentaro Sahashi, Masahisa Katsuno

EBioMedicine· April 2023

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Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.
Toshihide Takeuchi, Kazuhiro Maeta, Xin Ding, Yukako Oe, Akiko Takeda, Kentaro Sahashi

Mol Ther Nucleic Acids· March 2023

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The Japan Registry for Adult Subjects of Spinal Muscular Atrophy (jREACT-SMA): Protocol for a Longitudinal Observational Study.
Kentaro Sahashi, Atsushi Hashizume, Yachiyo Kuwatsuka, Madoka Chinen, Ai Saotome-Nakamura

JMIR Res Protoc· December 2022

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The 3'UTR Variant in ALS Patients Causes Aberrant Splicing and Dendritic Spine Loss by Recruiting HNRNPK.
Satoshi Yokoi, Takuji Ito, Kentaro Sahashi, Masahiro Nakatochi, Ryoichi Nakamura

J Neurosci· November 2022

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Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy.
Yosuke Ogura, Kentaro Sahashi, Tomoki Hirunagi, Madoka Iida, Takaki Miyata

Cell Death Dis· July 2022

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Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology.
Koyo Tsujikawa, Kohei Hamanaka, Yuichi Riku, Yuki Hattori, Norikazu Hara, Kentaro Sahashi

Sci Adv· May 2022

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Nucleic Acid-Based Therapeutic Approach for Spinal and Bulbar Muscular Atrophy and Related Neurological Disorders.
Tomoki Hirunagi, Kentaro Sahashi, Katherine G Meilleur, Masahisa Katsuno

Genes (Basel)· January 2022

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Significance of Oligomeric and Fibrillar Species in Amyloidosis: Insights into Pathophysiology and Treatment.
Haruki Koike, Yohei Iguchi, Kentaro Sahashi, Masahisa Katsuno

Molecules· August 2021

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Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.
Tomoki Hirunagi, Kentaro Sahashi, Kiyoshi Tachikawa, Angel I Leu, Michelle Nguyen

Mol Ther Nucleic Acids· June 2021

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NUS1 mutation in a family with epilepsy, cerebellar ataxia, and tremor.
Kunihiko Araki, Ryoichi Nakamura, Daisuke Ito, Kohji Kato, Yohei Iguchi, Kentaro Sahashi

Epilepsy Res· August 2020

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Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy.
Madoka Iida, Kentaro Sahashi, Naohide Kondo, Hideaki Nakatsuji, Genki Tohnai

Nat Commun· September 2019

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DNA methylation inhibitor attenuates polyglutamine-induced neurodegeneration by regulating Hes5.
Naohide Kondo, Genki Tohnai, Kentaro Sahashi, Madoka Iida, Mayumi Kataoka

EMBO Mol Med· May 2019

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Preclinical progression of neurodegenerative diseases.
Masahisa Katsuno, Kentaro Sahashi, Yohei Iguchi, Atsushi Hashizume

Nagoya J Med Sci· August 2018

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Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice.
Rahul Sinha, Young Jin Kim, Tomoki Nomakuchi, Kentaro Sahashi, Yimin Hua

Nucleic Acids Res· June 2018

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HMGCR antibody-associated myopathy as a paraneoplastic manifestation of esophageal carcinoma.
Koyo Tsujikawa, Kazuhiro Hara, Yoshinao Muro, Hirotaka Nakanishi, Yukiko Niwa, Kentaro Sahashi

Neurology· August 2016

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BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1.
Ying Ding, Hiroaki Adachi, Masahisa Katsuno, Kentaro Sahashi, Naohide Kondo

Neuroscience· July 2016

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Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy.
Kentaro Sahashi, Masahisa Katsuno, Gene Hung, Hiroaki Adachi, Naohide Kondo

Hum Mol Genet· November 2015

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