Publications by authors named "Yohei Iguchi"

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The TDP-43 heterozygous mutation results in increased TDP-43 expression and altered neuronal activity in ALS patient-derived iPSC motor neurons.
Ryo Chikuchi, Yuta Kato, Aya Tomatsu, Shuto Nishisaki, Yu Kawakami, Yohei Iguchi

Neurosci Res· December 2025

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Absence of the axon initial segment in sensory neuron enhances resistance to amyotrophic lateral sclerosis.
Nguyen Thu Tra, Sumiko Kiryu-Seo, Haruku Kida, Koji Wakatsuki, Yoshitaka Tashiro, Yohei Iguchi

Brain· November 2025

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A Family with Patients Manifesting Different Phenotypes of Neuromuscular Disease Depending on the CGG Repeat Number in LRP12.
Yohei Iguchi, Koyo Tsujikawa, Ayuka Murakami, Kodai Kume, Yuka Nakazawa

Intern Med· October 2025

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Corrigendum to ``P72. Change of spinal cord alignment within one week after cervical laminoplasty'' [North American Spine Society Journal (NASSJ) 18S (2024) 100476].
Tatsuya Shibata, Yoshikuni Kida, Jun Tanaka, Hideki Ota, Yohei Iguchi

N Am Spine Soc J· September 2025

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Truncation mutation of CHMP2B disrupts late endosome function but reduces TDP-43 aggregation through HSP70 upregulation.
Yohei Iguchi, Yuhei Takahashi, Jiayi Li, Yoshinobu Amakusa, Yu Kawakami

Neurochem Int· July 2025

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Downregulation of due to loss of TDP-43 function exacerbates motor neuron degeneration in amyotrophic lateral sclerosis.
Yu Kawakami, Yohei Iguchi, Jiayi Li, Yoshinobu Amakusa, Takashi Yoshimura

Brain Commun· July 2025

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Dysregulated synaptic gene expression in oligodendrocytes of spinal and bulbar muscular atrophy.
Madoka Iida, Kentaro Sahashi, Tomoki Hirunagi, Kenji Sakakibara, Kentaro Maeda, Yohei Iguchi

JCI Insight· June 2025

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Dual-modified antisense oligonucleotides targeting oncogenic protocadherin to treat gastric cancer.
Mitsuro Kanda, Yuuya Kasahara, Dai Shimizu, Takahiro Shinozuka, Masahiro Sasahara, Yohei Iguchi

Br J Cancer· November 2024

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[Current Status of Drug Development for Amyotrophic Lateral Sclerosis].
Yohei Iguchi, Masahisa Katsuno

Brain Nerve· November 2024

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Reliability and consistency of the Japanese version of the Primary Lateral Sclerosis Functional Rating Scale.
Masaru Yanagihashi, Takehisa Hirayama, Mari Shibukawa, Junpei Nagasawa, Koji Fujita, Yohei Iguchi

BMC Neurol· August 2024

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Autoantibodies Against Dihydrolipoamide S-Acetyltransferase in Immune-Mediated Neuropathies.
Yuki Fukami, Masahiro Iijima, Haruki H Koike, Satoru Yagi, Soma Furukawa, Yohei Iguchi

Neurol Neuroimmunol Neuroinflamm· March 2024

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IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation.
Yohei Iguchi, Yuhei Takahashi, Jiayi Li, Kunihiko Araki, Yoshinobu Amakusa

J Cell Biol· February 2024

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Perineural cyst with intracystic cerebrospinal fluid leakage by traction of nerve root -a case report.
Shusuke Hagihara, Hideki Ohta, Jun Tanaka, Teruaki Shiokawa, Yoshiyuki Matsumoto, Yohei Iguchi

J Orthop Sci· November 2023

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Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS.
Seiji Watanabe, Yuri Murata, Yasuyoshi Oka, Kotaro Oiwa, Mai Horiuchi, Yohei Iguchi

Proc Natl Acad Sci U S A· November 2023

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Negative Effects of Diffuse Idiopathic Skeletal Hyperostosis on Bone Fusion after Transforaminal Lumbar Interbody Fusion.
Shusuke Hagihara, Hideki Ohta, Jun Tanaka, Teruaki Shiokawa, Yoshikuni Kida, Yohei Iguchi

Asian Spine J· October 2023

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Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis.
Kotaro Oiwa, Seiji Watanabe, Kazunari Onodera, Yohei Iguchi, Yukako Kinoshita

Sci Adv· August 2023

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Neutrophil extracellular traps: from antimicrobial innate immunity to the development of chemotherapy-induced peripheral neuropathy.
Haruki Koike, Yohei Iguchi, Kentaro Sahashi, Masahisa Katsuno

EBioMedicine· April 2023

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Severe cervical kyphosis in a young adult with fixed dropped head syndrome, dysphagia, and myelopathy: A case report.
Tatsuya Shibata, Hideki Ota, Yoshiharu Takemitsu, Yohei Iguchi, Yoshikuni Kida

J Orthop Sci· April 2023

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Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons.
Sumiko Kiryu-Seo, Reika Matsushita, Yoshitaka Tashiro, Takeshi Yoshimura, Yohei Iguchi

EMBO J· October 2022

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Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology.
Koyo Tsujikawa, Kohei Hamanaka, Yuichi Riku, Yuki Hattori, Norikazu Hara, Yohei Iguchi

Sci Adv· May 2022

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Blockade of CHRNB2 signaling with a therapeutic monoclonal antibody attenuates the aggressiveness of gastric cancer cells.
Mitsuro Kanda, Dai Shimizu, Shunsuke Nakamura, Koichi Sawaki, Shinichi Umeda, Yohei Iguchi

Oncogene· September 2021

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Significance of Oligomeric and Fibrillar Species in Amyloidosis: Insights into Pathophysiology and Treatment.
Haruki Koike, Yohei Iguchi, Kentaro Sahashi, Masahisa Katsuno

Molecules· August 2021

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The wide-ranging clinical and genetic features in Japanese families with valosin-containing protein proteinopathy.
Takashi Ando, Ryoichi Nakamura, Satoshi Kuru, Daichi Yokoi, Naoki Atsuta, Yohei Iguchi

Neurobiol Aging· April 2021

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Pathway from TDP-43-Related Pathology to Neuronal Dysfunction in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration.
Yuichi Riku, Danielle Seilhean, Charles Duyckaerts, Susana Boluda, Yohei Iguchi

Int J Mol Sci· April 2021

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Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43.
Seiji Watanabe, Hidekazu Inami, Kotaro Oiwa, Yuri Murata, Shohei Sakai, Yohei Iguchi

Cell Death Dis· October 2020

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