Publications by authors named "Kerrie Faia"

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CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen.
Nealia C House, Maxine M Chen, Sima Khazaei, Victoria Brown, Philip Ramsden, Kerrie L Faia

NPJ Breast Cancer· December 2025

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Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors.
Nealia C House, Victoria E Brown, Maxine Chen, Liang Yuan, Sydney L Moore, Kerrie L Faia

Cancer Res· April 2025

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A novel DNA repair protein, N-Myc downstream regulated gene 1 (NDRG1), links stromal tumour microenvironment to chemoresistance.
Nina Kozlova, Kayla A Cruz, Hanna M Doh, Antoine A Ruzette, Nicholas A Willis, Kerrie L Faia

bioRxiv· January 2025

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The phosphoinositide-3 kinase (PI3K)-δ,γ inhibitor, duvelisib shows preclinical synergy with multiple targeted therapies in hematologic malignancies.
Kerrie Faia, Kerry White, Erin Murphy, Jennifer Proctor, Melissa Pink

PLoS One· January 2019

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Duvelisib, an oral dual PI3K-δ,γ inhibitor, shows clinical and pharmacodynamic activity in chronic lymphocytic leukemia and small lymphocytic lymphoma in a phase 1 study.
Susan O'Brien, Manish Patel, Brad S Kahl, Steven M Horwitz, Francine M Foss, Kerrie Faia

Am J Hematol· November 2018

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Impact of the Smoothened inhibitor, IPI-926, on smoothened ciliary localization and Hedgehog pathway activity.
Marisa O Peluso, Veronica T Campbell, Joseph A Harari, Thomas T Tibbitts, Jennifer L Proctor, Kerrie L Faia

PLoS One· December 2014

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PI3K-δ and PI3K-γ inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models.
David G Winkler, Kerrie L Faia, Jonathan P DiNitto, Janid A Ali, Kerry F White

Chem Biol· November 2013

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The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway.
Sherri Smith, Jennifer Hoyt, Nigel Whitebread, Joseph Manna, Marisa Peluso, Kerrie Faia

Xenobiotica· October 2013

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Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors.
Antonio Jimeno, Glen J Weiss, Wilson H Miller, Scott Gettinger, Bernard J C Eigl, Kerrie Faia

Clin Cancer Res· May 2013

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Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists.
Martin R Tremblay, Marta Nevalainen, Somarajan J Nair, James R Porter, Alfredo C Castro, Kerrie Faia

J Med Chem· November 2008

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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Katherine A Fitzgerald, Sarah M McWhirter, Kerrie L Faia, Daniel C Rowe, Eicke Latz

Nat Immunol· May 2003

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Matrix metalloproteinases and tissue inhibitors of metalloproteinases in hamster aortic atherosclerosis: correlation with in-situ zymography.
Kerrie L Faia, Wendell P Davis, Adele J Marone, Thomas L Foxall

Atherosclerosis· February 2002

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