Publications by authors named "Kevin D Mangum"

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IL-17A is increased in diabetic wounds and impairs keratinocyte function via histone demethylase JMJD3.
Jadie Y Moon, Sonya J Wolf, Amrita D Joshi, He Zhang, James Shadiow, Kevin D Mangum

Nat Commun· December 2025

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TNF-α represses fibroblast to myofibroblast transition through the histone methyltransferase Setdb2.
Tyler M Bauer, Kevin D Mangum, Samuel D Buckley, James Shadiow, Amrita D Joshi

JCI Insight· November 2025

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Epigenetic alteration of smooth muscle cells regulates endothelin-dependent blood pressure and hypertensive arterial remodeling.
Kevin D Mangum, Qinmengge Li, Katherine Hartmann, Tyler M Bauer, Sonya J Wolf

J Clin Invest· June 2025

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Inhibition of vascular smooth muscle cell PERK/ATF4 ER stress signaling protects against abdominal aortic aneurysms.
Brennan Callow, Xiaobing He, Nicholas Juriga, Kevin D Mangum, Amrita Joshi

JCI Insight· January 2025

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The STAT3/SETDB2 axis dictates NF-κB-mediated inflammation in macrophages during wound repair.
Kevin D Mangum, Aaron denDekker, Qinmengge Li, Lam C Tsoi, Amrita D Joshi

JCI Insight· October 2024

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The histone methyltransferase Mixed-lineage-leukemia-1 drives T cell phenotype via Notch signaling in diabetic tissue repair.
William J Melvin, Tyler M Bauer, Kevin D Mangum, Christopher O Audu, James Shadiow

JCI Insight· August 2024

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Epigenetic Alteration of Smooth Muscle Cells Regulates Endothelin-Dependent Blood Pressure and Hypertensive Arterial Remodeling.
Kevin D Mangum, Qinmengge Li, Tyler M Bauer, Sonya J Wolf, James Shadiow

medRxiv· July 2024

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Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells.
Christopher O Audu, Sonya J Wolf, Amrita D Joshi, Jadie Y Moon, William J Melvin, Kevin D Mangum

JCI Insight· June 2024

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Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility.
Meng Zou, Kevin D Mangum, Justin C Magin, Heidi H Cao, Michael T Yarboro

JCI Insight· March 2023

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Obesity confers macrophage memory.
Kevin D Mangum, Katherine A Gallagher

Science· January 2023

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Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair.
Christopher O Audu, William J Melvin, Amrita D Joshi, Sonya J Wolf, Jadie Y Moon, Kevin D Mangum

Cell Mol Immunol· November 2022

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Genetic and epigenetic regulation of abdominal aortic aneurysms.
Kevin D Mangum, Mark A Farber

Clin Genet· June 2020

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Transcriptional and posttranscriptional regulation of the SMC-selective blood pressure-associated gene, ARHGAP42.
Kevin D Mangum, Emily J Freeman, Justin C Magin, Joan M Taylor, Christopher P Mack

Am J Physiol Heart Circ Physiol· February 2020

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A novel familial truncating mutation in the filamin C gene associated with cardiac arrhythmias.
Kevin D Mangum, Sunita J Ferns

Eur J Med Genet· April 2019

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Druggable targets in the Rho pathway and their promise for therapeutic control of blood pressure.
Rachel A Dee, Kevin D Mangum, Xue Bai, Christopher P Mack, Joan M Taylor

Pharmacol Ther· January 2019

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Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.
Xue Bai, Kevin D Mangum, Rachel A Dee, George A Stouffer, Craig R Lee

J Clin Invest· February 2017

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Nuclear RhoA signaling regulates MRTF-dependent SMC-specific transcription.
Dean P Staus, Laura Weise-Cross, Kevin D Mangum, Matt D Medlin, Lee Mangiante

Am J Physiol Heart Circ Physiol· August 2014

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