Publications by authors named "Kevin Freeman-Cook"

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Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor.
Kevin Freeman-Cook, Robert L Hoffman, Nichol Miller, Jonathan Almaden, John Chionis

Cancer Cell· October 2021

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Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
Kevin D Freeman-Cook, Robert L Hoffman, Douglas C Behenna, Britton Boras, Jordan Carelli

J Med Chem· July 2021

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Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.
Casey L Quinlan, Stephen E Kaiser, Ben Bolaños, Dawn Nowlin, Rita Grantner, Kevin Freeman-Cook

Nat Chem Biol· July 2017

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Lipophilic efficiency: the most important efficiency metric in medicinal chemistry.
Kevin D Freeman-Cook, Robert L Hoffman, Ted W Johnson

Future Med Chem· February 2013

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Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists.
David W Piotrowski, Kentaro Futatsugi, Joseph S Warmus, Suvi T M Orr, Kevin D Freeman-Cook

ACS Med Chem Lett· January 2013

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Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase.
Kevin D Freeman-Cook, Paul Amor, Scott Bader, Leanne M Buzon, Steven B Coffey

J Med Chem· January 2012

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Synthesis and biological evaluation of novel hygromycin A antibacterial agents.
Michael S Visser, Kevin D Freeman-Cook, Steven J Brickner, Katherine E Brighty, Phuong T Le

Bioorg Med Chem Lett· November 2010

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Design of selective, ATP-competitive inhibitors of Akt.
Kevin D Freeman-Cook, Christopher Autry, Gary Borzillo, Deborah Gordon, Elsa Barbacci-Tobin

J Med Chem· June 2010

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Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
Jeffrey W Corbett, Kevin D Freeman-Cook, Richard Elliott, Felix Vajdos, Francis Rajamohan

Bioorg Med Chem Lett· April 2010

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Identification of an inhibitor of the MurC enzyme, which catalyzes an essential step in the peptidoglycan precursor synthesis pathway.
Laura E Zawadzke, Michael Norcia, Charlene R Desbonnet, Hong Wang, Kevin Freeman-Cook

Assay Drug Dev Technol· February 2008

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Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Kevin D Freeman-Cook, Lawrence A Reiter, Mark C Noe, Amy S Antipas, Dennis E Danley

Bioorg Med Chem Lett· December 2007

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Potent, selective pyrimidinetrione-based inhibitors of MMP-13.
Lawrence A Reiter, Kevin D Freeman-Cook, Christopher S Jones, Gary J Martinelli, Amy S Antipas

Bioorg Med Chem Lett· November 2006

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