Publications by authors named "Nichol Miller"

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Targeting BRAF Class II and III Mutations in NSCLC with the pan-RAF inhibitor Exarafenib Reveals ARAF-KSR1-Mediated Resistance and Rational Combination Strategies.
Tadashi Manabe, Hannah C Bergo, Qingtian Li, Tim Sen Wang, Paul Severson, Nichol Miller

Res Sq· October 2025

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CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety.
Cynthia L Palmer, Britton Boras, Bernadette Pascual, Na Li, Danan Li, Jennifer Lapira-Miller, Nichol Miller

Cancer Cell· March 2025

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Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer.
Rebecca A Gallego, Sujin Cho-Schultz, Matthew Del Bel, Anne-Marie Dechert-Schmitt, Joyann S Donaldson, Nichol Miller

J Med Chem· December 2024

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Discovery of Highly Selective Inhibitors of Microtubule-Associated Serine/Threonine Kinase-like (MASTL).
Rebecca A Gallego, Stephanie Scales, Chad Toledo, Marin Auth, Louise Bernier, Nichol Miller

J Med Chem· November 2024

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The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition.
Young K Chen, Toufike Kanouni, Lee D Arnold, Jason M Cox, Elisabeth Gardiner, Nichol Miller

J Med Chem· February 2024

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Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
John S Tyhonas, Lee D Arnold, Jason M Cox, Aleksandra Franovic, Elisabeth Gardiner, Nichol Miller

J Med Chem· February 2024

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Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
Rebecca A Gallego, Louise Bernier, Hui Chen, Sujin Cho-Schultz, Loanne Chung, Nichol Miller

J Med Chem· April 2023

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Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor.
Kevin Freeman-Cook, Robert L Hoffman, Nichol Miller, Jonathan Almaden, John Chionis

Cancer Cell· October 2021

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Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.
Kevin D Freeman-Cook, Robert L Hoffman, Douglas C Behenna, Britton Boras, Jordan Carelli, Nichol Miller

J Med Chem· July 2021

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Rgnef promotes ovarian tumor progression and confers protection from oxidative stress.
Elizabeth G Kleinschmidt, Nichol L G Miller, Duygu Ozmadenci, Isabelle Tancioni, Carlos Díaz Osterman

Oncogene· September 2019

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Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy.
Bruno Gomes, Gregory Driessens, Derek Bartlett, Danying Cai, Sandra Cauwenberghs, Nichol Miller

Mol Cancer Ther· December 2018

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Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.
Stefano Crosignani, Patrick Bingham, Pauline Bottemanne, Hélène Cannelle, Sandra Cauwenberghs, Nichol Miller

J Med Chem· December 2017

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Durability of Kinase-Directed Therapies--A Network Perspective on Response and Resistance.
Brion W Murray, Nichol Miller

Mol Cancer Ther· September 2015

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Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.
Miriam Masià-Balagué, Ismael Izquierdo, Georgina Garrido, Arnau Cordomí, Laura Pérez-Benito, Nichol L G Miller

J Biol Chem· June 2015

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FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth.
Isabelle Tancioni, Nichol L G Miller, Sean Uryu, Christine Lawson, Christine Jean

Breast Cancer Res· March 2015

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FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth.
Isabelle Tancioni, Sean Uryu, Florian J Sulzmaier, Nina R Shah, Christine Lawson, Nichol L G Miller

Mol Cancer Ther· August 2014

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Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer.
Nina R Shah, Isabelle Tancioni, Kristy K Ward, Christine Lawson, Xiao Lei Chen, Nichol L G Miller

Gynecol Oncol· July 2014

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Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function.
Christine Jean, Xiao Lei Chen, Ju-Ock Nam, Isabelle Tancioni, Sean Uryu, Nichol L G Miller

J Cell Biol· January 2014

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A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation.
Nichol L G Miller, Christine Lawson, Elizabeth G Kleinschmidt, Isabelle Tancioni, Sean Uryu

J Cell Sci· November 2013

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Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression.
Kristy K Ward, Isabelle Tancioni, Christine Lawson, Nichol L G Miller, Christine Jean

Clin Exp Metastasis· June 2013

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Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins.
Nichol L G Miller, Christine Lawson, Xiao Lei Chen, Ssang-Taek Lim, David D Schlaepfer

PLoS One· October 2012

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Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
Ssang-Taek Lim, Nichol L G Miller, Xiao Lei Chen, Isabelle Tancioni, Colin T Walsh

J Cell Biol· June 2012

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p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase.
Hong-Gang Yu, Ju-Ock Nam, Nichol L G Miller, Isabelle Tanjoni, Colin Walsh

Cancer Res· January 2011

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Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6.
Rachel Larder, Daniel D Clark, Nichol L G Miller, Pamela L Mellon

J Neurosci· January 2011

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