Publications by authors named "Young K Chen"

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The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition.
Young K Chen, Toufike Kanouni, Lee D Arnold, Jason M Cox, Elisabeth Gardiner

J Med Chem· February 2024

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TACH101, a first-in-class pan-inhibitor of KDM4 histone demethylase.
Chandtip Chandhasin, Van Dang, Frank Perabo, Joselyn Del Rosario, Young K Chen

Anticancer Drugs· November 2023

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Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1).
Toufike Kanouni, Christophe Severin, Robert W Cho, Natalie Y-Y Yuen, Jiangchun Xu, Young K Chen

J Med Chem· December 2020

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Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors.
Zhe Nie, Lihong Shi, Chon Lai, Christophe Severin, Jiangchun Xu, Young K Chen

Bioorg Med Chem Lett· January 2019

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Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
Young K Chen, Tiziana Bonaldi, Alessandro Cuomo, Joselyn R Del Rosario, David J Hosfield

ACS Med Chem Lett· August 2017

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One-pot multicomponent coupling methods for the synthesis of diastereo- and enantioenriched (Z)-trisubstituted allylic alcohols.
Michael H Kerrigan, Sang-Jin Jeon, Young K Chen, Luca Salvi, Patrick J Carroll

J Am Chem Soc· June 2009

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Enantioselective organocatalytic amine conjugate addition.
Young K Chen, Masanori Yoshida, David W C MacMillan

J Am Chem Soc· July 2006

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Catalytic asymmetric synthesis of hydroxy enol ethers: approach to a two-carbon homologation of aldehydes.
Sang-Jin Jeon, Young K Chen, Patrick J Walsh

Org Lett· April 2005

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A one-pot multicomponent coupling reaction for the stereocontrolled synthesis of (Z)-trisubstituted allylic alcohols.
Young K Chen, Patrick J Walsh

J Am Chem Soc· March 2004

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A general, highly enantioselective method for the synthesis of D and L alpha-amino acids and allylic amines.
Young K Chen, Alice E Lurain, Patrick J Walsh

J Am Chem Soc· October 2002

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