Publications by authors named "Chon Lai"

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Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders.
Arvind Shakya, Qiao Liu, Chon Lai, Sherry Baker, Steven Greene, Connor M Blair

J Transl Autoimmun· December 2025

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Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth.
Kyle Begovich, Angela Schoolmeesters, Navin Rajapakse, Elena Martinez-Terroba, Maneesh Kumar, Chon Lai

Mol Cancer Ther· April 2024

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On Ternary Complex Stability in Protein Degradation: In Silico Molecular Glue Binding Affinity Calculations.
Dahlia R Weiss, Andrea Bortolato, Yongnian Sun, Xianmei Cai, Chon Lai

J Chem Inf Model· April 2023

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Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1).
Toufike Kanouni, Christophe Severin, Robert W Cho, Natalie Y-Y Yuen, Jiangchun Xu, Chon Lai

J Med Chem· December 2020

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Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors.
Zhe Nie, Lihong Shi, Chon Lai, Christophe Severin, Jiangchun Xu

Bioorg Med Chem Lett· January 2019

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Structure-based design and discovery of potent and selective KDM5 inhibitors.
Zhe Nie, Lihong Shi, Chon Lai, Shawn M O'Connell, Jiangchun Xu

Bioorg Med Chem Lett· May 2018

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Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
Young K Chen, Tiziana Bonaldi, Alessandro Cuomo, Joselyn R Del Rosario, David J Hosfield, Chon Lai

ACS Med Chem Lett· August 2017

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RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer.
Cory Iverson, Gary Larson, Chon Lai, Li-Tain Yeh, Claudia Dadson

Cancer Res· September 2009

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