Publications by authors named "Lee D Arnold"

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The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition.
Young K Chen, Toufike Kanouni, Lee D Arnold, Jason M Cox, Elisabeth Gardiner

J Med Chem· February 2024

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Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
John S Tyhonas, Lee D Arnold, Jason M Cox, Aleksandra Franovic, Elisabeth Gardiner

J Med Chem· February 2024

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Evaluation of antiviral activity of SARS-CoV-2 M inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions.
Xiao Tong, Walter Keung, Lee D Arnold, Laura J Stevens, Andrea J Pruijssers

Antimicrob Agents Chemother· November 2023

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Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production.
Hélène Chabrolles, Héloïse Auclair, Serena Vegna, Thomas Lahlali, Caroline Pons, Lee D Arnold

PLoS Pathog· November 2020

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Novel, Self-Assembling Dimeric Inhibitors of Human β Tryptase.
Sarah F Giardina, Douglas S Werner, Maneesh Pingle, Philip B Feinberg, Kenneth W Foreman, Lee D Arnold

J Med Chem· March 2020

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A Novel, Nonpeptidic, Orally Active Bivalent Inhibitor of Human β-Tryptase.
Sarah F Giardina, Douglas S Werner, Maneesh Pingle, Donald E Bergstrom, Lee D Arnold

Pharmacology· December 2018

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Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase.
Sarah F Giardina, Douglas S Werner, Maneesh Pingle, Kenneth W Foreman, Donald E Bergstrom, Lee D Arnold

ACS Med Chem Lett· August 2018

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Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines.
Jutta Wanner, Darlene Romashko, Douglas S Werner, Earl W May, Yue Peng, Lee D Arnold

PLoS One· January 2016

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Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin.
Shripad V Bhagwat, Prafulla C Gokhale, Andrew P Crew, Andy Cooke, Yan Yao, Lee D Arnold

Mol Cancer Ther· August 2011

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Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2.
Andrew P Crew, Shripad V Bhagwat, Hanqing Dong, Mark A Bittner, Anna Chan, Lee D Arnold

Bioorg Med Chem Lett· April 2011

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Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor.
Mark J Mulvihill, Andrew Cooke, Maryland Rosenfeld-Franklin, Elizabeth Buck, Ken Foreman, Lee D Arnold

Future Med Chem· September 2009

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A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo.
Qun-sheng Ji, Mark J Mulvihill, Maryland Rosenfeld-Franklin, Andrew Cooke, Lixin Feng, Lee D Arnold

Mol Cancer Ther· August 2007

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1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
Jürgen Dinges, Daniel H Albert, Lee D Arnold, Kimba L Ashworth, Irini Akritopoulou-Zanze

J Med Chem· May 2007

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Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors.
Jürgen Dinges, Irini Akritopoulou-Zanze, Lee D Arnold, Teresa Barlozzari, Peter F Bousquet

Bioorg Med Chem Lett· August 2006

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1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors.
Jürgen Dinges, Kimba L Ashworth, Irini Akritopoulou-Zanze, Lee D Arnold, Steven A Baumeister

Bioorg Med Chem Lett· August 2006

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OSI-930: a novel selective inhibitor of Kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models.
Andrew J Garton, Andrew P A Crew, Maryland Franklin, Andrew R Cooke, Graham M Wynne, Lee D Arnold

Cancer Res· January 2006

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A 13C NMR approach to categorizing potential limitations of alpha,beta-unsaturated carbonyl systems in drug-like molecules.
Kevin P Cusack, Lee D Arnold, Claude E Barberis, Haipeng Chen, Anna M Ericsson

Bioorg Med Chem Lett· November 2004

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Inhibition of vascular endothelial growth factor receptor (VEGFR) signaling by BSF476921 attenuates regional cerebral edema following traumatic brain injury in rats.
Philipp M Lenzlinger, Kathryn E Saatman, Rachel C Hoover, Jessica A Cheney, Florence M Bareyre, Lee D Arnold

Restor Neurol Neurosci· September 2004

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