Publications by authors named "Kevin M Cottrell"

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MTA-Cooperative PRMT5 Inhibitors Are Efficacious in MTAP-Deleted Malignant Peripheral Nerve Sheath Tumor Models.
Xiaochun Zhang, Dana C Borcherding, Minjie Zhang, Yang Lyu, Guangfeng Wang, Kevin M Cottrell

Clin Cancer Res· November 2025

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Discovery of TNG462: A Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitor to Target Cancers with Deletion.
Kevin M Cottrell, Kimberly J Briggs, Alice Tsai, Matthew R Tonini, Douglas A Whittington

J Med Chem· March 2025

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TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor developed for the treatment of MTAP-deleted cancers.
Kimberly J Briggs, Kevin M Cottrell, Matthew R Tonini, Alice Tsai, Minjie Zhang

Transl Oncol· February 2025

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MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design.
Kevin M Cottrell, Douglas A Whittington, Kimberly J Briggs, Haris Jahic, Janid A Ali

J Med Chem· February 2025

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Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with -Deleted Cancers.
Kevin M Cottrell, Kimberly J Briggs, Douglas A Whittington, Haris Jahic, Janid A Ali

J Med Chem· April 2024

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Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors.
Upul K Bandarage, Alex M Aronov, Jingrong Cao, Jon H Come, Kevin M Cottrell

ACS Med Chem Lett· January 2021

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Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3-Kinase γ.
Philip N Collier, David Messersmith, Arnaud Le Tiran, Upul K Bandarage, Christina Boucher, Kevin M Cottrell

J Med Chem· July 2015

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Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores.
James A Henderson, Darius Bilimoria, Monica Bubenik, Caroline Cadilhac, Kevin M Cottrell

Bioorg Med Chem Lett· February 2015

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Benzimidazole-containing HCV NS5A inhibitors: effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency.
James A Henderson, Darius Bilimoria, Monica Bubenik, Caroline Cadilhac, Kevin M Cottrell

Bioorg Med Chem Lett· February 2015

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Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-symmetric inhibitors with diyne and biphenyl linkers.
Simon Giroux, Darius Bilimoria, Caroline Cadilhac, Kevin M Cottrell, Francois Denis

Bioorg Med Chem Lett· February 2015

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Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: non-symmetric inhibitors with potent activity against genotype 1a and 1b.
Simon Giroux, Darius Bilimoria, Caroline Cadilhac, Kevin M Cottrell, Francois Denis

Bioorg Med Chem Lett· February 2015

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Structural basis for isoform selectivity in a class of benzothiazole inhibitors of phosphoinositide 3-kinase γ.
Philip N Collier, Gabriel Martinez-Botella, Mark Cornebise, Kevin M Cottrell, John D Doran

J Med Chem· January 2015

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Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors.
Simon Giroux, Jinwang Xu, T Jagadeeswar Reddy, Mark Morris, Kevin M Cottrell

ACS Med Chem Lett· March 2014

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Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics.
Robert B Perni, Gurudatt Chandorkar, Kevin M Cottrell, Cynthia A Gates, Chao Lin

Bioorg Med Chem Lett· June 2007

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In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms.
Chao Lin, Kai Lin, Yu-Ping Luong, B Govinda Rao, Yun-Yi Wei, Kevin M Cottrell

J Biol Chem· April 2004

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Inhibitors of hepatitis C virus NS3.4A protease. Part 3: P2 proline variants.
Robert B Perni, Luc J Farmer, Kevin M Cottrell, John J Court, Lawrence F Courtney

Bioorg Med Chem Lett· April 2004

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