Publications by authors named "Kevin Pinney"

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Donor-Derived Cell-Free DNA Trajectory Identifies Subclinical Rejection in Kidney Transplant Recipients.
Sandesh Parajuli, Emily E Zona, Neetika Garg, Tatyana Lawrecki, Shree Patel, Kevin Pinney

Kidney360· November 2025

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Donor-Derived Cell-Free DNA in Antibody-Mediated Rejection: An Analysis of the Surveillance HeartCare Outcomes Registry.
Paul J Kim, Amit H Alam, Jeffrey J Teuteberg, Kiran K Khush, Sean P Pinney, Kevin M Pinney

JACC Heart Fail· October 2025

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Targeting Tumor-Associated Hypoxia with Bioreductively Activatable Prodrug Conjugates Derived from Dihydronaphthalene, Benzosuberene, and Indole-based Inhibitors of Tubulin Polymerization.
Zhe Shi, Rajsekhar Guddneppanavar, Blake A Winn, Matthew T MacDonough, Clinton S George, Kevin G Pinney

RSC Med Chem· August 2025

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Benzosuberene and Tetracyclic Analogues as Colchicine Site Inhibitors of Tubulin Polymerization.
Jennifer M VanNatta, Graham J Carlson, Haichan Niu, Ruoli Bai, Hashini I Wanniarachchi, Kevin G Pinney

ACS Med Chem Lett· June 2025

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Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents.
Rebecca Vairin, Caleb Tamminga, Zhe Shi, Christian Borchardt, Jayaram Jambulapati, Kevin G Pinney

Bioorg Med Chem· February 2025

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Drug-Linker Constructs Bearing Unique Dual-Mechanism Tubulin Binding Payloads Tethered through Cleavable and Non-Cleavable Linkers.
Jacob W Ford, Jennifer M VanNatta, Deboprosad Mondal, Chen-Ming Lin, Yuling Deng, Kevin G Pinney

Tetrahedron· February 2025

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Evaluating Therapeutic Efficacy of the Vascular Disrupting Agent OXi8007 Against Kidney Cancer in Mice.
Hashini I Wanniarachchi, Regan Schuetze, Yuling Deng, Khagendra B Hamal, Cyprian I Pavlich, Kevin G Pinney

Cancers (Basel)· February 2025

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Application of Chlorosulfonyl Isocyanate (CSI) in the Synthesis of Fused Tetracyclic Ketone Ring Systems.
Jennifer M VanNatta, Haichan Niu, Graham J Carlson, Kevin G Pinney

J Org Chem· November 2024

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Changes in Donor-Derived Cell-Free DNA Before and After Rejection and De Novo DSA Detection in Primary and Repeat Kidney Transplant Recipients.
Sandesh Parajuli, Neetika Garg, Ban Dodin, Isabel Breyer, Emily Zona, Kevin Pinney

Clin Transplant· November 2024

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Surveillance with dual noninvasive testing for acute cellular rejection after heart transplantation: Outcomes from the Surveillance HeartCare Outcomes Registry.
Kiran Khush, Shelley Hall, Andrew Kao, Nirav Raval, Ravi Dhingra, Sean Pinney, Kevin Pinney

J Heart Lung Transplant· September 2024

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Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization.
Wen Ren, Yuling Deng, Jacob D Ward, Rebecca Vairin, Ruoli Bai, Kevin G Pinney

Eur J Med Chem· January 2024

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Structure Guided Design, Synthesis, and Biological Evaluation of Oxetane-Containing Indole Analogues.
Wen Ren, Rebecca Vairin, Jacob D Ward, Ricardo Francis, Jenny VanNatta, Kevin G Pinney

Bioorg Med Chem· September 2023

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Synthesis of the Hypoxia-Inducible Factor-2 (HIF-2) Inhibitor, 3-[(1,2,3)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977, Belzutifan); Efficient Replication of Established Approaches.
Khagendra B Hamal, Cyprian I Pavlich, Graham J Carlson, Yu Ching Wong, Fangzhou Zhao, Kevin G Pinney

Tetrahedron Lett· September 2023

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Oxygen-Sensing Chemiluminescent Iridium(III) 1,2-Dioxetanes: Unusual Coordination and Activity.
Husain N Kagalwala, Lorena Bueno, Hashini Wanniarachchi, Daniel K Unruh, Khagendra B Hamal, Kevin G Pinney

Anal Sens· January 2023

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Demonstrating Tumor Vascular Disrupting Activity of the Small-Molecule Dihydronaphthalene Tubulin-Binding Agent OXi6196 as a Potential Therapeutic for Cancer Treatment.
Li Liu, Regan Schuetze, Jeni L Gerberich, Ramona Lopez, Samuel O Odutola, Kevin G Pinney

Cancers (Basel)· August 2022

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Validation of a gene expression signature to measure immune quiescence in kidney transplant recipients in the CLIA setting.
Rocky Cheung, Hua Xu, Xia Jin, Wenlan Tian, Kevin Pinney

Biomark Med· June 2022

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Imaging-Guided Evaluation of the Novel Small-Molecule Benzosuberene Tubulin-Binding Agent KGP265 as a Potential Therapeutic Agent for Cancer Treatment.
Yihang Guo, Honghong Wang, Jeni L Gerberich, Samuel O Odutola, Amanda K Charlton-Sevcik, Kevin G Pinney

Cancers (Basel)· September 2021

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Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors.
Li Liu, Devin O'Kelly, Regan Schuetze, Graham Carlson, Heling Zhou, Kevin G Pinney

Molecules· April 2021

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Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia.
Blake A Winn, Laxman Devkota, Bunnarack Kuch, Matthew T MacDonough, Tracy E Strecker, Kevin G Pinney

J Nat Prod· April 2020

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Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues.
Casey J Maguire, Graham J Carlson, Jacob W Ford, Tracy E Strecker, Ernest Hamel, Kevin G Pinney

Medchemcomm· August 2019

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Structure Guided Design, Synthesis, and Biological Evaluation of Novel Benzosuberene Analogues as Inhibitors of Tubulin Polymerization.
Haichan Niu, Tracy E Strecker, Jeni L Gerberich, James W Campbell, Debabrata Saha, Kevin G Pinney

J Med Chem· June 2019

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Efficient Synthetic Methodology for the Construction of Dihydronaphthalene and Benzosuberene Molecular Frameworks.
Deboprosad Mondal, Haichan Niu, Kevin G Pinney

Tetrahedron Lett· January 2019

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Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents.
Casey J Maguire, Zhi Chen, Vani P Mocharla, Madhavi Sriram, Tracy E Strecker, Kevin G Pinney

Medchemcomm· October 2018

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Improved Methodology for the Synthesis of a Cathepsin B Cleavable Dipeptide Linker, Widely Used in Antibody-Drug Conjugate Research.
Deboprosad Mondal, Jacob Ford, Kevin G Pinney

Tetrahedron Lett· October 2018

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Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization.
Christine A Herdman, Tracy E Strecker, Rajendra P Tanpure, Zhi Chen, Alex Winters, Kevin G Pinney

Medchemcomm· December 2016

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