Publications by authors named "Kevin Strange"

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Recent advances in structural characterization of volume-regulated anion channels (VRACs).
Erkan Karakas, Kevin Strange, Jerod S Denton

J Physiol· August 2025

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Cryo-EM structures of an LRRC8 chimera with native functional properties reveal heptameric assembly.
Hirohide Takahashi, Toshiki Yamada, Jerod S Denton, Kevin Strange, Erkan Karakas

Elife· March 2023

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LRRC8A homohexameric channels poorly recapitulate VRAC regulation and pharmacology.
Toshiki Yamada, Eric E Figueroa, Jerod S Denton, Kevin Strange

Am J Physiol Cell Physiol· March 2021

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CysLT1 receptor antagonists pranlukast and zafirlukast inhibit LRRC8-mediated volume regulated anion channels independently of the receptor.
Eric E Figueroa, Meghan Kramer, Kevin Strange, Jerod S Denton

Am J Physiol Cell Physiol· October 2019

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A Shot at Regeneration.
Viravuth Yin, Kevin Strange

Sci Am· April 2019

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A 30-year journey from volume-regulated anion currents to molecular structure of the LRRC8 channel.
Kevin Strange, Toshiki Yamada, Jerod S Denton

J Gen Physiol· February 2019

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Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function.
Toshiki Yamada, Kevin Strange

J Gen Physiol· July 2018

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Abnormal Osmotic Avoidance Behavior in C. elegans Is Associated with Increased Hypertonic Stress Resistance and Improved Proteostasis.
Elaine C Lee, Heejung Kim, Jennifer Ditano, Dacie Manion, Benjamin L King, Kevin Strange

PLoS One· March 2017

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The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues.
Ashley M Smith, Katie K Maguire-Nguyen, Thomas A Rando, Michael A Zasloff, Kevin B Strange

NPJ Regen Med· March 2017

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Drug Discovery in Fish, Flies, and Worms.
Kevin Strange

ILAR J· December 2016

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Role of CBS and Bateman Domains in Phosphorylation-Dependent Regulation of a CLC Anion Channel.
Toshiki Yamada, Mickael Krzeminski, Zoltan Bozoky, Julie D Forman-Kay, Kevin Strange

Biophys J· November 2016

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Regulatory Conformational Coupling between CLC Anion Channel Membrane and Cytoplasmic Domains.
Toshiki Yamada, Kevin Strange

Biophys J· November 2016

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Leucine-rich repeat containing protein LRRC8A is essential for swelling-activated Cl- currents and embryonic development in zebrafish.
Toshiki Yamada, Robert Wondergem, Rebecca Morrison, Viravuth P Yin, Kevin Strange

Physiol Rep· October 2016

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The Skp1 Homologs SKR-1/2 Are Required for the Caenorhabditis elegans SKN-1 Antioxidant/Detoxification Response Independently of p38 MAPK.
Cheng-Wei Wu, Andrew Deonarine, Aaron Przybysz, Kevin Strange, Keith P Choe

PLoS Genet· October 2016

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The voltage-gated anion channels encoded by clh-3 regulate egg laying in C. elegans by modulating motor neuron excitability.
Robyn Branicky, Hiroaki Miyazaki, Kevin Strange, William R Schafer

J Neurosci· January 2014

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Changes in translation rate modulate stress-induced damage of diverse proteins.
Heejung Kim, Kevin Strange

Am J Physiol Cell Physiol· December 2013

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Regulatory phosphorylation induces extracellular conformational changes in a CLC anion channel.
Toshiki Yamada, Manasi P Bhate, Kevin Strange

Biophys J· May 2013

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GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.
Elaine Choung-Hee Lee, Kevin Strange

Am J Physiol Cell Physiol· December 2012

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Rhythmic Ca²⁺ signaling: keeping time with microRNAs.
Kevin Strange, Viravuth P Yin

Curr Biol· December 2012

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CLC anion channel regulatory phosphorylation and conserved signal transduction domains.
Hiroaki Miyazaki, Toshiki Yamada, Angela Parton, Rebecca Morrison, Sunghoon Kim, Kevin Strange

Biophys J· October 2012

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Characterization of the proteostasis roles of glycerol accumulation, protein degradation and protein synthesis during osmotic stress in C. elegans.
Kristopher Burkewitz, Keith P Choe, Elaine Choung-Hee Lee, Andrew Deonarine, Kevin Strange

PLoS One· August 2012

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Differential regulation of a CLC anion channel by SPAK kinase ortholog-mediated multisite phosphorylation.
Hiroaki Miyazaki, Kevin Strange

Am J Physiol Cell Physiol· June 2012

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Hypertonic stress induces rapid and widespread protein damage in C. elegans.
Kris Burkewitz, Keith Choe, Kevin Strange

Am J Physiol Cell Physiol· September 2011

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Putting the pieces together: a crystal clear window into CLC anion channel regulation.
Kevin Strange

Channels (Austin)· July 2011

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High-throughput screening and biosensing with fluorescent C. elegans strains.
Chi K Leung, Andrew Deonarine, Kevin Strange, Keith P Choe

J Vis Exp· May 2011

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