Publications by authors named "Kim Sharp"

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Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients.
Alastair L Smith, Nicholas Denny, Catherine Chahrour, Kim Sharp, Marta Arachi

Blood· October 2025

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Metabolic activation of flunitrazepam via nitroreduction mediated by aldo-keto reductase 1C3.
Cátia F Marques, Maya Narang, Kim A Sharp, Trevor M Penning

Drug Metab Dispos· September 2025

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Functional and Mechanistic Explanation for the Unique Clinical Success of the Glucokinase Activator Dorzagliatin in the Treatment of Type 2 Diabetes.
Jeff Roman, Yue Yuan, Yue Xu, Qiusha Zhu, Shaowen Wu, Kim Sharp

Diabetes· August 2025

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Specific and potent inhibition of steroid hormone pre-receptor regulator AKR1C2 by perfluorooctanoic acid: Implications for androgen metabolism.
Andrea Andress Huacachino, Anna Chung, Kim Sharp, Trevor M Penning

J Steroid Biochem Mol Biol· February 2025

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A Novel In Vitro Model of the Bone Marrow Microenvironment in Acute Myeloid Leukemia Identifies CD44 and Focal Adhesion Kinase as Therapeutic Targets to Reverse Cell Adhesion-Mediated Drug Resistance.
Eleni E Ladikou, Kim Sharp, Fabio A Simoes, John R Jones, Thomas Burley

Cancers (Basel)· January 2025

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Copy number evolution and its relationship with patient outcome-an analysis of 178 matched presentation-relapse tumor pairs from the Myeloma XI trial.
James Croft, Sidra Ellis, Amy L Sherborne, Kim Sharp, Amy Price

Leukemia· July 2021

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Computational Graphics Software for Interactive Docking and Visualization of Ligand-Protein Complementarity.
Saravana G Baskaran, Thayne P Sharp, Kim A Sharp

J Chem Inf Model· March 2021

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Companion Simulations and Modeling to NMR-Based Dynamical Studies of Proteins.
Kim A Sharp

Methods Enzymol· November 2019

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DNA Conformational Changes Play a Force-Generating Role during Bacteriophage Genome Packaging.
Kim A Sharp, Xiang-Jun Lu, Gino Cingolani, Stephen C Harvey

Biophys J· June 2019

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Water loading driven size, shape, and composition of cetyltrimethylammonium/hexanol/pentane reverse micelles.
Brian Fuglestad, Kushol Gupta, A Joshua Wand, Kim A Sharp

J Colloid Interface Sci· March 2019

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Measuring Entropy in Molecular Recognition by Proteins.
A Joshua Wand, Kim A Sharp

Annu Rev Biophys· May 2018

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Entropy in molecular recognition by proteins.
José A Caro, Kyle W Harpole, Vignesh Kasinath, Jackwee Lim, Jeffrey Granja, Kim A Sharp

Proc Natl Acad Sci U S A· June 2017

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On the ability of molecular dynamics force fields to recapitulate NMR derived protein side chain order parameters.
Evan S O'Brien, A Joshua Wand, Kim A Sharp

Protein Sci· June 2016

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Characterization of Cetyltrimethylammonium Bromide/Hexanol Reverse Micelles by Experimentally Benchmarked Molecular Dynamics Simulations.
Brian Fuglestad, Kushol Gupta, A Joshua Wand, Kim A Sharp

Langmuir· February 2016

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Unpacking the origins of in-cell crowding.
Kim A Sharp

Proc Natl Acad Sci U S A· February 2016

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TCR triggering by pMHC ligands tethered on surfaces via poly(ethylene glycol) depends on polymer length.
Zhengyu Ma, David N LeBard, Sharon M Loverde, Kim A Sharp, Michael L Klein

PLoS One· July 2015

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Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation.
Karthik Raju, Paschalis-Thomas Doulias, Perry Evans, Elizabeth N Krizman, Joshua G Jackson, Kim A Sharp

Sci Signal· July 2015

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Analysis of the size dependence of macromolecular crowding shows that smaller is better.
Kim A Sharp

Proc Natl Acad Sci U S A· June 2015

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On the relationship between NMR-derived amide order parameters and protein backbone entropy changes.
Kim A Sharp, Evan O'Brien, Vignesh Kasinath, A Joshua Wand

Proteins· May 2015

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A sharp thermal transition of fast aromatic-ring dynamics in ubiquitin.
Vignesh Kasinath, Yinan Fu, Kim A Sharp, A Joshua Wand

Angew Chem Int Ed Engl· January 2015

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The remarkable hydration of the antifreeze protein Maxi: a computational study.
Kim A Sharp

J Chem Phys· December 2014

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Banding of NMR-derived methyl order parameters: implications for protein dynamics.
Kim A Sharp, Vignesh Kasinath, A Joshua Wand

Proteins· September 2014

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Biochemistry. Protein folding, interrupted.
Kim A Sharp

Science· February 2014

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Microscopic insights into the NMR relaxation-based protein conformational entropy meter.
Vignesh Kasinath, Kim A Sharp, A Joshua Wand

J Am Chem Soc· October 2013

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Calculation of Molecular Entropies Using Temperature Integration.
Kim Sharp

J Chem Theory Comput· February 2013

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