Publications by authors named "Kin-Ming Lo"

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Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses.
Yan Lan, Tsz-Lun Yeung, Hui Huang, Ansgar A Wegener, Somdutta Saha, George Locke, Maria Soloviev, Kin-Ming Lo

J Immunother Cancer· July 2022

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NHS-IL12 and bintrafusp alfa combination therapy enhances antitumor activity in preclinical cancer models.
Chunxiao Xu, Bo Marelli, Jin Qi, Guozhong Qin, Huakui Yu, Kin-Ming Lo

Transl Oncol· February 2022

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Addition of an Fc-IgG induces receptor clustering and increases the in vitro efficacy and in vivo anti-tumor properties of the thrombospondin-1 type I repeats (3TSR) in a mouse model of advanced stage ovarian cancer.
Kathy Matuszewska, Simone Ten Kortenaar, Madison Pereira, Lisa A Santry, Duncan Petrik, Kin-Ming Lo

Gynecol Oncol· January 2022

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Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion.
Yan Lan, Mahmoud Moustafa, Maximilian Knoll, Chunxiao Xu, Jennifer Furkel, George Locke, Kin-Ming Lo

Cancer Cell· October 2021

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Correction to: 33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018).
Sneha Berry, Nicolas Giraldo, Peter Nguyen, Benjamin Green, Haiying Xu, Charlotte Lemech, Damian Trujillo, Kin-Ming Lo, Matthew Taylor, Carlos Encarnacion, Matthew Taylor, Carlos Encarnacion, Matthew Taylor

J Immunother Cancer· February 2019

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Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β.
Yan Lan, Dong Zhang, Chunxiao Xu, Kenneth W Hance, Bo Marelli, George Locke, Laszlo Radvanyi, Kin-Ming Lo

Sci Transl Med· January 2018

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Combination Therapy with NHS-muIL12 and Avelumab (anti-PD-L1) Enhances Antitumor Efficacy in Preclinical Cancer Models.
Chunxiao Xu, Yanping Zhang, P Alexander Rolfe, Vivian M Hernández, Wilson Guzman, Kin-Ming Lo, Laszlo Radvanyi

Clin Cancer Res· October 2017

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A Survey of Wireless Sensor Network Based Air Pollution Monitoring Systems.
Wei Ying Yi, Kin Ming Lo, Terrence Mak, Kwong Sak Leung, Yee Leung

Sensors (Basel)· December 2015

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Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans.
Jeremy D Waight, Shinji Takai, Bo Marelli, Guozhong Qin, Kenneth W Hance, Kin-Ming Lo

J Immunol· February 2015

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Antibody Engineering.
Kin-Ming Lo, Olivier Leger, Björn Hock

Microbiol Spectr· February 2014

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A low-toxicity IL-2-based immunocytokine retains antitumor activity despite its high degree of IL-2 receptor selectivity.
Stephen D Gillies, Yan Lan, Thore Hettmann, Beatrice Brunkhorst, Yaping Sun, Kin-Ming Lo

Clin Cancer Res· June 2011

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SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies.
Jonathan H Davis, Christel Aperlo, Yue Li, Emmi Kurosawa, Yan Lan, Kin-Ming Lo

Protein Eng Des Sel· April 2010

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Immunogenicity of the hu14.18-IL2 immunocytokine molecule in adults with melanoma and children with neuroblastoma.
Jacquelyn A Hank, Jacek Gan, Hyunji Ryu, Amy Ostendorf, Michael C Stauder, Kin-Ming Lo

Clin Cancer Res· September 2009

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Linking antibody Fc domain to endostatin significantly improves endostatin half-life and efficacy.
Tong-Young Lee, Robert M Tjin Tham Sjin, Shahla Movahedi, Bissan Ahmed, Elke A Pravda, Kin-Ming Lo

Clin Cancer Res· March 2008

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huBC1-IL12, an immunocytokine which targets EDB-containing oncofetal fibronectin in tumors and tumor vasculature, shows potent anti-tumor activity in human tumor models.
Kin-Ming Lo, Yan Lan, Scott Lauder, Jinyang Zhang, Beatrice Brunkhorst

Cancer Immunol Immunother· April 2007

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An anti-CD20-IL-2 immunocytokine is highly efficacious in a SCID mouse model of established human B lymphoma.
Stephen D Gillies, Yan Lan, Steven Williams, Frank Carr, Stephen Forman, Kin-Ming Lo

Blood· May 2005

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Improvement of Fc-erythropoietin structure and pharmacokinetics by modification at a disulfide bond.
Jeffrey C Way, Scott Lauder, Beatrice Brunkhorst, Su-Ming Kong, An Qi, Kin-Ming Lo

Protein Eng Des Sel· March 2005

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Engineering a pharmacologically superior form of leptin for the treatment of obesity.
Kin-Ming Lo, Jinyang Zhang, Yaping Sun, Bo Morelli, Yan Lan

Protein Eng Des Sel· January 2005

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The development of a modified human IFN-alpha2b linked to the Fc portion of human IgG1 as a novel potential therapeutic for the treatment of hepatitis C virus infection.
Tim D Jones, Marian Hanlon, Beverley J Smith, Charles T Heise, Prakash D Nayee, Kin-Ming Lo

J Interferon Cytokine Res· September 2004

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Use of methotrexate-based peptide substrates to characterize the substrate specificity of prostate-specific membrane antigen (PSMA).
Annastasiah Mhaka, Alyssa M Gady, D Marc Rosen, Kin-Ming Lo, Steven D Gillies

Cancer Biol Ther· June 2004

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Targeting of adenovirus via genetic modification of the viral capsid combined with a protein bridge.
Nikolay Korokhov, Galina Mikheeva, Alexander Krendelshchikov, Natalya Belousova, Vera Simonenko, Kin-Ming Lo

J Virol· December 2003

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Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis.
Karen S Moulton, Khashayar Vakili, David Zurakowski, Mohsin Soliman, Catherine Butterfield, Kin-Ming Lo

Proc Natl Acad Sci U S A· April 2003

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Laminin modulates morphogenic properties of the collagen XVIII endostatin domain.
Kashi Javaherian, Susan Y Park, Winfried F Pickl, Kenneth R LaMontagne, Robert Tjin Tham Sjin, Kin-Ming Lo

J Biol Chem· November 2002

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Bi-functional cytokine fusion proteins for gene therapy and antibody-targeted treatment of cancer.
Stephen D Gillies, Yan Lan, Bea Brunkhorst, Wai-Keung Wong, Yue Li, Kin-Ming Lo

Cancer Immunol Immunother· October 2002

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Improved circulating half-life and efficacy of an antibody-interleukin 2 immunocytokine based on reduced intracellular proteolysis.
Stephen D Gillies, Kin-Ming Lo, Christa Burger, Yan Lan, Thomas Dahl

Clin Cancer Res· January 2002

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