Publications by authors named "Kip West"

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Metabolic modulation of tumours with engineered bacteria for immunotherapy.
Fernando P Canale, Camilla Basso, Gaia Antonini, Michela Perotti, Ning Li, Kip A West

Nature· October 2021

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Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity.
Daniel S Leventhal, Anna Sokolovska, Ning Li, Christopher Plescia, Starsha A Kolodziej, Kip A West

Nat Commun· June 2020

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An engineered Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans.
Caroline B Kurtz, Yves A Millet, Marja K Puurunen, Mylène Perreault, Mark R Charbonneau, Kip A West

Sci Transl Med· January 2019

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Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.
Michael J Thomenius, Jennifer Totman, Darren Harvey, Lorna H Mitchell, Thomas V Riera, Kip West

PLoS One· December 2018

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Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria.
Vincent M Isabella, Binh N Ha, Mary Joan Castillo, David J Lubkowicz, Sarah E Rowe, Kip A West

Nat Biotechnol· October 2018

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Systems biology driving drug development: from design to the clinical testing of the anti-ErbB3 antibody seribantumab (MM-121).
Birgit Schoeberl, Art Kudla, Kristina Masson, Ashish Kalra, Michael Curley, Kip West

NPJ Syst Biol Appl· January 2017

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Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor.
Lorna H Mitchell, P Ann Boriack-Sjodin, Sherri Smith, Michael Thomenius, Nathalie Rioux, Kip West

ACS Med Chem Lett· February 2016

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HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer.
Brenda C O'Connell, Katie O'Callaghan, Bonnie Tillotson, Mark Douglas, Nafeeza Hafeez, Kip A West

PLoS One· August 2015

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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Elayne Chan-Penebre, Kristy G Kuplast, Christina R Majer, P Ann Boriack-Sjodin, Tim J Wigle, Kip A West

Nat Chem Biol· June 2015

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Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors.
Tao Liu, Somarajan J Nair, André Lescarbeau, Jitendra Belani, Stéphane Peluso, Kip West

J Med Chem· October 2012

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Hedgehog-Gli pathway activation during kidney fibrosis.
Steven L Fabian, Radostin R Penchev, Benoit St-Jacques, Anjali N Rao, Petra Sipilä, Kip A West

Am J Pathol· April 2012

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Starting with the ABCs: Akt in breast cancer.
Kip A West, Phillip A Dennis

Mol Cancer Ther· November 2011

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Antitumor activity of the Hsp90 inhibitor IPI-504 in HER2-positive trastuzumab-resistant breast cancer.
Maurizio Scaltriti, Violeta Serra, Emmanuel Normant, Marta Guzman, Olga Rodriguez, Kip A West

Mol Cancer Ther· May 2011

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Hsp90 (heat shock protein 90) inhibitor occupancy is a direct determinant of client protein degradation and tumor growth arrest in vivo.
Bonnie Tillotson, Kelly Slocum, John Coco, Nigel Whitebread, Brian Thomas, Kip A West

J Biol Chem· December 2010

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Ansamycin inhibitors of Hsp90: nature's prototype for anti-chaperone therapy.
James R Porter, Jie Ge, John Lee, Emmanuel Normant, Kip West

Curr Top Med Chem· February 2010

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The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo.
Mark Douglas, Alice R Lim, James R Porter, Kip West, Melissa M Pink

Mol Cancer Ther· December 2009

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Therapeutically targeting ErbB3: a key node in ligand-induced activation of the ErbB receptor-PI3K axis.
Birgit Schoeberl, Emily A Pace, Jonathan B Fitzgerald, Brian D Harms, Lihui Xu, Kip A West

Sci Signal· June 2009

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Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy.
Junji Tsurutani, Kip A West, Jacqueline Sayyah, Joell J Gills, Phillip A Dennis

Cancer Res· September 2005

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Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo.
Kip A West, Ilona R Linnoila, John Brognard, Steven Belinsky, Curtis Harris

Chest· May 2004

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Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues.
S Sianna Castillo, John Brognard, Pavel A Petukhov, Chunyu Zhang, Junji Tsurutani, Kip A West

Cancer Res· April 2004

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Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo.
Kip A West, Ilona R Linnoila, Steven A Belinsky, Curtis C Harris, Phillip A Dennis

Cancer Res· January 2004

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Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance.
Amy S Clark, Kip A West, Peter M Blumberg, Phillip A Dennis

Cancer Res· February 2003

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Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells.
Kip A West, John Brognard, Amy S Clark, Ilona R Linnoila, Xiaowei Yang

J Clin Invest· January 2003

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Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
Kip A West, S Sianna Castillo, Phillip A Dennis

Drug Resist Updat· December 2002

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Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.
Amy S Clark, Kip West, Samantha Streicher, Phillip A Dennis

Mol Cancer Ther· July 2002

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