Publications by authors named "Kirk Nelson"

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Discovery of TYRA-300: First Oral Selective FGFR3 Inhibitor for the Treatment of Urothelial Cancers and Achondroplasia.
Robert L Hudkins, Eric Allen, Alexandra Balcer, Isaac D Hoffman, Samhita Iyer, Kirk J Nelson

J Med Chem· September 2024

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potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing .
Olga Lomovskaya, Mariana Castanheira, Jill Lindley, Debora Rubio-Aparicio, Kirk Nelson

Antimicrob Agents Chemother· November 2023

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Intrinsic Antibacterial Activity of Xeruborbactam : Assessing Spectrum and Mode of Action.
Dongxu Sun, Ruslan Tsivkovski, Joe Pogliano, Hannah Tsunemoto, Kirk Nelson

Antimicrob Agents Chemother· October 2022

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Activity of the Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Multiple Beta-Lactam Antibiotics against Pseudomonas aeruginosa.
Olga Lomovskaya, Debora Rubio-Aparicio, Kirk Nelson, Dongxu Sun, Ruslan Tsivkovski

Antimicrob Agents Chemother· May 2021

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Activity of the Ultra-Broad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Meropenem against Clinical Isolates of Carbapenem-Resistant Acinetobacter baumannii.
Kirk Nelson, Debora Rubio-Aparicio, Ruslan Tsivkovski, Dongxu Sun, Maxim Totrov

Antimicrob Agents Chemother· October 2020

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Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases.
Scott J Hecker, K Raja Reddy, Olga Lomovskaya, David C Griffith, Debora Rubio-Aparicio, Kirk Nelson

J Med Chem· July 2020

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Activity of the Ultrabroad-Spectrum-Beta-Lactamase Inhibitor QPX7728 against Carbapenem-Resistant with Varying Intrinsic and Acquired Resistance Mechanisms.
Kirk Nelson, Debora Rubio-Aparicio, Dongxu Sun, Michael Dudley, Olga Lomovskaya

Antimicrob Agents Chemother· July 2020

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Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases.
Olga Lomovskaya, Ruslan Tsivkovski, Kirk Nelson, Debora Rubio-Aparicio, Dongxu Sun

Antimicrob Agents Chemother· May 2020

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Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in , Pseudomonas aeruginosa, and Acinetobacter baumannii.
Olga Lomovskaya, Kirk Nelson, Debora Rubio-Aparicio, Ruslan Tsivkovski, Dongxu Sun

Antimicrob Agents Chemother· May 2020

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Absence of TetB identifies minocycline-susceptible isolates of Acinetobacter baumannii.
Olga Lomovskaya, Dongxu Sun, Debora Rubio-Aparicio, Kirk J Nelson, Visanu Thamlikitkul

Int J Antimicrob Agents· September 2018

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Meropenem-Vaborbactam Resistance Selection, Resistance Prevention, and Molecular Mechanisms in Mutants of KPC-Producing Klebsiella pneumoniae.
Dongxu Sun, Debora Rubio-Aparicio, Kirk Nelson, Michael N Dudley, Olga Lomovskaya

Antimicrob Agents Chemother· December 2017

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Impact on physical therapy and audiology students of an interprofessional case-based learning experience in education of vestibular disorders.
Rachel D Trommelen, Laurie Hebert, T Kirk Nelson

J Allied Health· November 2017

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Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae.
Olga Lomovskaya, Dongxu Sun, Debora Rubio-Aparicio, Kirk Nelson, Ruslan Tsivkovski

Antimicrob Agents Chemother· November 2017

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Resistance to Ceftazidime-Avibactam Is Due to Transposition of KPC in a Porin-Deficient Strain of Klebsiella pneumoniae with Increased Efflux Activity.
Kirk Nelson, Peera Hemarajata, Dongxu Sun, Debora Rubio-Aparicio, Ruslan Tsivkovski

Antimicrob Agents Chemother· October 2017

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Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents.
Leslie W Tari, Xiaoming Li, Michael Trzoss, Daniel C Bensen, Zhiyong Chen, Kirk J Nelson

PLoS One· August 2014

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Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.
Thanh Lam, Mark T Hilgers, Mark L Cunningham, Bryan P Kwan, Kirk J Nelson

J Med Chem· February 2014

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Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay.
Mark L Cunningham, Bryan P Kwan, Kirk J Nelson, Daniel C Bensen, Karen J Shaw

J Biomol Screen· October 2013

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Comment on "extending applicability of correlation equations to predict colloidal retention in porous media at low fluid velocity".
Kirk E Nelson, Timothy R Ginn, Tamir Kamai

Environ Sci Technol· July 2013

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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity.
Micheal Trzoss, Daniel C Bensen, Xiaoming Li, Zhiyong Chen, Thanh Lam, Kirk Nelson

Bioorg Med Chem Lett· March 2013

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Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines.
Xiaoming Li, Mark Hilgers, Mark Cunningham, Zhiyong Chen, Michael Trzoss, Kirk Nelson

Bioorg Med Chem Lett· September 2011

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Comment on particle tracking model for colloid transport near planar surfaces covered with spherical asperities.
Kirk E Nelson, Timothy R Ginn

Langmuir· November 2009

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Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors.
Leslie W Tari, Isaac D Hoffman, Daniel C Bensen, Michael J Hunter, Jay Nix, Kirk J Nelson

Bioorg Med Chem Lett· February 2007

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Colloid filtration theory and the Happel sphere-in-cell model revisited with direct numerical simulation of colloids.
Kirk E Nelson, Timothy R Ginn

Langmuir· March 2005

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