Publications by authors named "Mark Hilgers"

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Author Correction: Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy.
Severine Isabelle Gharbi, Laura A Pelletier, Alfonso Espada, Jesus Gutiérrez, Sonia Maria Gutiérrez Sanfeliciano, Mark T Hilgers

NPJ Breast Cancer· December 2022

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Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy.
Severine Isabelle Gharbi, Laura A Pelletier, Alfonso Espada, Jesus Gutiérrez, Sonia Maria Gutiérrez Sanfeliciano, Mark T Hilgers

NPJ Breast Cancer· November 2022

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Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics.
Karen Froning, Jack Maguire, Arlene Sereno, Flora Huang, Shawn Chang, Mark T Hilgers

Nat Commun· May 2020

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Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines.
Thanh Lam, Mark T Hilgers, Mark L Cunningham, Bryan P Kwan, Kirk J Nelson

J Med Chem· February 2014

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Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.
Min Teng, Mark T Hilgers, Mark L Cunningham, Allen Borchardt, Jeffrey B Locke

J Med Chem· February 2013

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Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines.
Xiaoming Li, Mark Hilgers, Mark Cunningham, Zhiyong Chen, Michael Trzoss

Bioorg Med Chem Lett· September 2011

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Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations.
Jeffrey B Locke, John Finn, Mark Hilgers, Gracia Morales, Shahad Rahawi

Antimicrob Agents Chemother· December 2010

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Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3.
Jeffrey B Locke, Gracia Morales, Mark Hilgers, Kedar G C, Shahad Rahawi

Antimicrob Agents Chemother· December 2010

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Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700).
Jeffrey B Locke, Mark Hilgers, Karen Joy Shaw

Antimicrob Agents Chemother· December 2009

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Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin.
Jeffrey B Locke, Mark Hilgers, Karen Joy Shaw

Antimicrob Agents Chemother· December 2009

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Identification of novel inhibitors of methionyl-tRNA synthetase (MetRS) by virtual screening.
John Finn, Mark Stidham, Mark Hilgers, Kedar G C

Bioorg Med Chem Lett· July 2008

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Comparison of the essential cellular functions of the two murA genes of Bacillus anthracis.
G C Kedar, Vickie Brown-Driver, Daniel R Reyes, Mark T Hilgers, Mark A Stidham

Antimicrob Agents Chemother· June 2008

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Evaluation of the metS and murB loci for antibiotic discovery using targeted antisense RNA expression analysis in Bacillus anthracis.
G C Kedar, Vickie Brown-Driver, Daniel R Reyes, Mark T Hilgers, Mark A Stidham

Antimicrob Agents Chemother· May 2007

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Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.
David J Hosfield, Yiqin Wu, Robert J Skene, Mark Hilgers, Andy Jennings

J Biol Chem· February 2005

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Structures of the N-terminal modules imply large domain motions during catalysis by methionine synthase.
John C Evans, Donald P Huddler, Mark T Hilgers, Gail Romanchuk, Rowena G Matthews

Proc Natl Acad Sci U S A· March 2004

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Crystal structures of active fully assembled substrate- and product-bound complexes of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) from Haemophilus influenzae.
Clifford D Mol, Alexei Brooun, Douglas R Dougan, Mark T Hilgers, Leslie W Tari

J Bacteriol· July 2003

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A fully integrated protein crystallization platform for small-molecule drug discovery.
David Hosfield, John Palan, Mark Hilgers, Daniel Scheibe, Duncan E McRee

J Struct Biol· April 2003

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