Publications by authors named "David Hosfield"

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ProT-VAE: Protein Transformer Variational AutoEncoder for functional protein design.
Emre Sevgen, Joshua Moller, Adrian Lange, John Parker, Sean Quigley, David Hosfield

Proc Natl Acad Sci U S A· October 2025

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Evaluating steroid hormone receptor interactions using the live-cell NanoBRET proximity assay.
Rosemary J Huggins, David Hosfield, Amira Ishag-Osman, Keemin Lee, Elia Ton-That

bioRxiv· July 2023

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Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in mutant breast cancer cells.
David J Hosfield, Sandra Weber, Nan-Sheng Li, Madline Sauvage, Carstyn F Joiner

Elife· May 2022

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Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1).
Toufike Kanouni, Christophe Severin, Robert W Cho, Natalie Y-Y Yuen, Jiangchun Xu, David Hosfield

J Med Chem· December 2020

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The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.
Sean W Fanning, Rinath Jeselsohn, Venkatasubramanian Dharmarajan, Christopher G Mayne, Mostafa Karimi, David J Hosfield

Elife· November 2018

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Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer.
Diana C West, Masha Kocherginsky, Eva Y Tonsing-Carter, D Nesli Dolcen, David J Hosfield

Clin Cancer Res· July 2018

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Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors.
Michael J Bennett, Yiqin Wu, Amogh Boloor, Jennifer Matuszkiewicz, Shawn M O'Connell, David J Hosfield

Bioorg Med Chem Lett· June 2018

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Structure-based design and discovery of potent and selective KDM5 inhibitors.
Zhe Nie, Lihong Shi, Chon Lai, Shawn M O'Connell, Jiangchun Xu, David J Hosfield

Bioorg Med Chem Lett· May 2018

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Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
Young K Chen, Tiziana Bonaldi, Alessandro Cuomo, Joselyn R Del Rosario, David J Hosfield

ACS Med Chem Lett· August 2017

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Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators.
Zacharia S Cheruvallath, Stephen L Gwaltney, Mark Sabat, Mingnam Tang, Haixia Wang, David Hosfield

Bioorg Med Chem Lett· June 2017

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Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors.
Andre Kiryanov, Srinivasa Natala, Benjamin Jones, Christopher McBride, Victoria Feher, David Hosfield

Bioorg Med Chem Lett· March 2017

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Discovery of TAK-960: an orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Zhe Nie, Victoria Feher, Srinivasa Natala, Christopher McBride, Andre Kiryanov, David Hosfield

Bioorg Med Chem Lett· June 2013

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Design, synthesis and SAR of novel glucokinase activators.
Zacharia S Cheruvallath, Stephen L Gwaltney, Mark Sabat, Mingnam Tang, Jun Feng, David Hosfield

Bioorg Med Chem Lett· April 2013

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Overcoming mutation-based resistance to antiandrogens with rational drug design.
Minna D Balbas, Michael J Evans, David J Hosfield, John Wongvipat, Vivek K Arora

Elife· April 2013

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Discovery and characterization of novel allosteric FAK inhibitors.
Misa Iwatani, Hidehisa Iwata, Atsutoshi Okabe, Robert J Skene, Naoki Tomita, David J Hosfield

Eur J Med Chem· March 2013

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Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.
Susan E Tsutakawa, David S Shin, Clifford D Mol, Tadahide Izumi, Andrew S Arvai, David J Hosfield

J Biol Chem· March 2013

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Structure-based discovery of cellular-active allosteric inhibitors of FAK.
Naoki Tomita, Yoko Hayashi, Shinkichi Suzuki, Yoshimasa Oomori, Yoshio Aramaki, David J Hosfield

Bioorg Med Chem Lett· March 2013

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X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.
Xavier Fradera, Diep Vu, Olaf Nimz, Robert Skene, David Hosfield

J Mol Biol· May 2010

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DNA apurinic-apyrimidinic site binding and excision by endonuclease IV.
Elsa D Garcin, David J Hosfield, Sunil A Desai, Brian J Haas, Magnar Björas

Nat Struct Mol Biol· May 2008

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Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.
David J Hosfield, Yiqin Wu, Robert J Skene, Mark Hilgers, Andy Jennings

J Biol Chem· February 2005

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Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.
Elsa D Garcin, Christopher M Bruns, Sarah J Lloyd, David J Hosfield, Mauro Tiso

J Biol Chem· September 2004

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Structural insights into the conformational selectivity of STI-571 and related kinase inhibitors.
Clifford D Mol, Doriano Fabbro, David J Hosfield

Curr Opin Drug Discov Devel· September 2004

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Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis.
David J Hosfield, Yanming Zhang, Douglas R Dougan, Alexei Broun, Leslie W Tari

J Biol Chem· March 2004

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Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair.
Brian R Chapados, David J Hosfield, Seungil Han, Junzhuan Qiu, Biana Yelent

Cell· January 2004

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Crystal structure of Pasteurella haemolytica ferric ion-binding protein A reveals a novel class of bacterial iron-binding proteins.
Stephen R Shouldice, Douglas R Dougan, Pamela A Williams, Robert J Skene, Gyorgy Snell, David J Hosfield

J Biol Chem· October 2003

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