Publications by authors named "Andy Jennings"

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D
Design and Discovery of a Potent and Selective Inhibitor of Integrin αvβ1.
Mark Sabat, Daniel W Carney, Gloria Hernandez-Torres, Tony S Gibson, Deepika Balakrishna, Andy Jennings

J Med Chem· June 2024

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Signal peptide mimicry primes Sec61 for client-selective inhibition.
Shahid Rehan, Dale Tranter, Phillip P Sharp, Gregory B Craven, Eric Lowe, Andy Jennings

Nat Chem Biol· September 2023

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Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.
Edouard Mullarky, Jiayi Xu, Anita D Robin, David J Huggins, Andy Jennings

Bioorg Med Chem Lett· September 2019

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Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Lodoe Lama, Carolina Adura, Wei Xie, Daisuke Tomita, Taku Kamei, Andy J Jennings

Nat Commun· May 2019

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Trelagliptin (SYR-472, Zafatek), Novel Once-Weekly Treatment for Type 2 Diabetes, Inhibits Dipeptidyl Peptidase-4 (DPP-4) via a Non-Covalent Mechanism.
Charles E Grimshaw, Andy Jennings, Ruhi Kamran, Hikaru Ueno, Nobuhiro Nishigaki

PLoS One· July 2017

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Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators.
Zacharia S Cheruvallath, Stephen L Gwaltney, Mark Sabat, Mingnam Tang, Haixia Wang, Andy Jennings

Bioorg Med Chem Lett· June 2017

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Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes.
Marion Lanier, Derek C Cole, Yelena Istratiy, Michael G Klein, Phillip A Schwartz, Andy Jennings

J Med Chem· June 2017

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Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK).
Betty Lam, Yasuyoshi Arikawa, Joshua Cramlett, Qing Dong, Ron de Jong, Andy Jennings

Bioorg Med Chem Lett· December 2016

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High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875.
Ankita Srivastava, Jason Yano, Yoshihiko Hirozane, Georgia Kefala, Franz Gruswitz, Andy Jennings

Nature· September 2014

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A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT).
Marion Lanier, Geza Ambrus, Derek C Cole, Richard Davenport, Jonathan Ellery, Andy J Jennings

J Med Chem· June 2014

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Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors.
Anthony R Gangloff, Jason Brown, Ron de Jong, Douglas R Dougan, Charles E Grimshaw, Andy Jennings

Bioorg Med Chem Lett· August 2013

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Design, synthesis and SAR of novel glucokinase activators.
Zacharia S Cheruvallath, Stephen L Gwaltney, Mark Sabat, Mingnam Tang, Jun Feng, Andy Jennings

Bioorg Med Chem Lett· April 2013

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Chemical informatics: using molecular shape descriptors in structure-based drug design.
Andy Jennings

Methods Mol Biol· May 2012

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Structural analysis of the mechanism of inhibition and allosteric activation of the kinase domain of HER2 protein.
Kathleen Aertgeerts, Robert Skene, Jason Yano, Bi-Ching Sang, Hua Zou, Andy Jennings

J Biol Chem· May 2011

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Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV.
Zhiyuan Zhang, Michael B Wallace, Jun Feng, Jeffrey A Stafford, Robert J Skene, Andy Jennings

J Med Chem· January 2011

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Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity.
Jerome C Bressi, Ron de Jong, Yiqin Wu, Andy J Jennings, Jason W Brown

Bioorg Med Chem Lett· May 2010

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Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides.
Jerome C Bressi, Andy J Jennings, Robert Skene, Yiqin Wu, Robert Melkus

Bioorg Med Chem Lett· May 2010

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Use of high-throughput crystallography and in silico methods for structure-based drug design.
Leslie W Tari, Duncan E McRee, Andy J Jennings

Methods Biochem Anal· April 2009

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Selection of molecules based on shape and electrostatic similarity: proof of concept of "electroforms".
Andy Jennings, Mike Tennant

J Chem Inf Model· November 2007

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Discovery strategies in a pharmaceutical setting: the application of computational techniques.
Andy Jennings, Mike Tennant

Expert Opin Drug Discov· December 2006

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Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha.
Kathleen Aertgeerts, Irena Levin, Lihong Shi, Gyorgy P Snell, Andy Jennings

J Biol Chem· May 2005

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Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.
David J Hosfield, Yiqin Wu, Robert J Skene, Mark Hilgers, Andy Jennings

J Biol Chem· February 2005

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Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.
John R Somoza, Robert J Skene, Bradley A Katz, Clifford Mol, Joseph D Ho, Andy J Jennings

Structure· July 2004

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