Publications by authors named "Klaus Schiene"

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Inhibition of experimental visceral pain in rodents by cebranopadol.
Klaus Schiene, Wolfgang Schröder, Klaus Linz, Stefanie Frosch, Thomas M Tzschentke

Behav Pharmacol· June 2019

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Nociceptin/orphanin FQ opioid peptide (NOP) receptor and µ-opioid peptide (MOP) receptors both contribute to the anti-hypersensitive effect of cebranopadol in a rat model of arthritic pain.
Klaus Schiene, Wolfgang Schröder, Klaus Linz, Stefanie Frosch, Thomas M Tzschentke

Eur J Pharmacol· August 2018

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Investigation of TRPV1 loss-of-function phenotypes in TRPV1 Leu206Stop mice generated by N-ethyl-N-nitrosourea mutagenesis.
Thomas Christoph, Babette Kögel, Klaus Schiene, Thomas Peters, Wolfgang Schröder

Biochem Biophys Res Commun· June 2018

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Mechanical hyperalgesia in rats with diabetic polyneuropathy is selectively inhibited by local peripheral nociceptin/orphanin FQ receptor and µ-opioid receptor agonism.
Klaus Schiene, Thomas M Tzschentke, Wolfgang Schröder, Thomas Christoph

Eur J Pharmacol· May 2015

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Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists.
HyungChul Ryu, Sejin Seo, Jee-Young Lee, Tae-Hwan Ha, Sunho Lee, Klaus Schiene

Eur J Med Chem· March 2015

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6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonists.
Wei Sun, Hyo-Shin Kim, Sunho Lee, Aeran Jung, Sung-Eun Kim, Klaus Schiene

Bioorg Med Chem Lett· February 2015

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Pharmacogenomic study of the role of the nociceptin/orphanin FQ receptor and opioid receptors in diabetic hyperalgesia.
Kris Rutten, Thomas M Tzschentke, Thomas Koch, Klaus Schiene, Thomas Christoph

Eur J Pharmacol· October 2014

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2-Alkyl/alkenyl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists.
HyungChul Ryu, Sejin Seo, Seong-Hee Cho, Ho Shin Kim, Aeran Jung, Klaus Schiene

Bioorg Med Chem Lett· August 2014

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Cebranopadol: a novel potent analgesic nociceptin/orphanin FQ peptide and opioid receptor agonist.
Klaus Linz, Thomas Christoph, Thomas M Tzschentke, Thomas Koch, Klaus Schiene

J Pharmacol Exp Ther· June 2014

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TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides.
Tae-Hwan Ha, Hyungchul Ryu, Sung-Eun Kim, Ho Shin Kim, Jihyae Ann, Klaus Schiene

Bioorg Med Chem· November 2013

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2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: structure activity relationships of the 2-oxy pyridine C-region.
Shivaji A Thorat, Dong Wook Kang, HyungChul Ryu, Myeong Seop Kim, Ho Shin Kim, Klaus Schiene

Eur J Med Chem· June 2013

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2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: structure-activity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3-ylmethyl) C-region.
Myeong Seop Kim, HyungChul Ryu, Dong Wook Kang, Seong-Hee Cho, Sejin Seo, Klaus Schiene

J Med Chem· October 2012

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Mechanistic and functional differentiation of tapentadol and tramadol.
Robert B Raffa, Helmut Buschmann, Thomas Christoph, Gary Eichenbaum, Werner Englberger, Klaus Schiene

Expert Opin Pharmacother· July 2012

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Antinociceptive and antihyperalgesic effects of tapentadol in animal models of inflammatory pain.
Klaus Schiene, Jean De Vry, Thomas M Tzschentke

J Pharmacol Exp Ther· November 2011

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Synergistic antihypersensitive effects of pregabalin and tapentadol in a rat model of neuropathic pain.
Thomas Christoph, Jean De Vry, Klaus Schiene, Ronald J Tallarida, Thomas M Tzschentke

Eur J Pharmacol· September 2011

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Tapentadol hydrochloride: a next-generation, centrally acting analgesic with two mechanisms of action in a single molecule.
Thomas M Tzschentke, Ulrich Jahnel, Babette Kogel, Thomas Christoph, Werner Englberger, Klaus Schiene

Drugs Today (Barc)· July 2009

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Differential effects of morphine on the affective and the sensory component of carrageenan-induced nociception in the rat.
Elizabeth Louise van der Kam, Jean De Vry, Klaus Schiene, Thomas Michael Tzschentke

Pain· June 2008

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Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice.
Thomas Christoph, Gregor Bahrenberg, Jean De Vry, Werner Englberger, Volker A Erdmann, Klaus Schiene

Mol Cell Neurosci· March 2008

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(-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic properties.
Thomas M Tzschentke, Thomas Christoph, Babette Kögel, Klaus Schiene, Hagen-Heinrich Hennies

J Pharmacol Exp Ther· October 2007

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Antinociceptive effect of antisense oligonucleotides against the vanilloid receptor VR1/TRPV1.
Thomas Christoph, Clemens Gillen, Joanna Mika, Arnold Grünweller, Martin K-H Schäfer, Klaus Schiene

Neurochem Int· January 2007

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The antiallodynic effect of NMDA antagonists in neuropathic pain outlasts the duration of the in vivo NMDA antagonism.
Thomas Christoph, Klaus Schiene, Werner Englberger, Chris G Parsons, Boris A Chizh

Neuropharmacology· July 2006

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Antiallodynic effects of NMDA glycine(B) antagonists in neuropathic pain: possible peripheral mechanisms.
Thomas Christoph, Elke Reissmüller, Klaus Schiene, Werner Englberger, Boris A Chizh

Brain Res· June 2005

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Broad analgesic profile of buprenorphine in rodent models of acute and chronic pain.
Thomas Christoph, Babette Kögel, Klaus Schiene, Murielle Méen, Jean De Vry

Eur J Pharmacol· January 2005

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