Publications by authors named "Kosuke Anan"

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Trifluoromethyl Dihydrothiazine-Based β-Secretase (BACE1) Inhibitors with Robust Central β-Amyloid Reduction and Minimal Covalent Binding Burden.
Kosuke Anan, Yasuyoshi Iso, Takuya Oguma, Kenji Nakahara, Shinji Suzuki

ChemMedChem· November 2019

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Discovery of NR2B-selective antagonists via scaffold hopping and pharmacokinetic profile optimization.
Kosuke Anan, Moriyasu Masui, Aya Tazawa, Minoru Tomida, Yoshihiro Haga

Bioorg Med Chem Lett· May 2019

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Synthesis of a 6-CF-Substituted 2-Amino-dihydro-1,3-thiazine β-Secretase Inhibitor by N, N-Diethylaminosulfur Trifluoride-Mediated Chemoselective Cyclization.
Takuya Oguma, Kosuke Anan, Shinji Suzuki, Shinya Hisakawa, Akihiro Takada

J Org Chem· April 2019

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Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach.
Kosuke Anan, Moriyasu Masui, Shinichiro Hara, Miho Ohara, Masaharu Kume

Bioorg Med Chem Lett· September 2017

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Side-chain chiral centers of amino acid and helical-screw handedness of its peptides.
Masakazu Tanaka, Kosuke Anan, Yosuke Demizu, Masaaki Kurihara, Mitsunobu Doi

J Am Chem Soc· August 2005

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