Publications by authors named "Kristin Beebe"

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The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with -Hsp90 Inhibition.
Sanket J Mishra, Weiya Liu, Kristin Beebe, Monimoy Banerjee, Caitlin N Kent

J Med Chem· February 2021

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Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors.
Khanh T Do, Geraldine O'Sullivan Coyne, John L Hays, Jeffrey G Supko, Stephen V Liu, Kristin Beebe

Cancer Chemother Pharmacol· December 2020

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Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function.
Joseph W Jackson, Genesis M Rivera-Marquez, Kristin Beebe, Andy D Tran, Jane B Trepel

J Thromb Haemost· May 2020

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Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.
Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R Brender

Cell Rep· February 2020

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The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis.
Abhinav Joshi, Li Dai, Yanxin Liu, Jungsoon Lee, Nastaran Mohammadi Ghahhari, Kristin Beebe

BMC Biol· January 2020

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Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1.
Wanping Xu, Kristin Beebe, Juan D Chavez, Marta Boysen, YinYing Lu

Nat Commun· June 2019

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Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer.
Michael A Moses, Yeong Sang Kim, Genesis M Rivera-Marquez, Nobu Oshima, Matthew J Watson, Kristin E Beebe

Cancer Res· July 2018

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HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation.
Toshiki Kijima, Thomas L Prince, Megan L Tigue, Kendrick H Yim, Harvey Schwartz, Kristin Beebe

Sci Rep· May 2018

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Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation.
Ashleigh B Bachman, Dimitra Keramisanou, Wanping Xu, Kristin Beebe, Michael A Moses

Nat Commun· January 2018

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An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans.
Abbey D Zuehlke, Michael Reidy, Coney Lin, Paul LaPointe, Sarah Alsomairy, Kristin Beebe

Nat Commun· May 2017

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Targeting Hsp90 in Non-Cancerous Maladies.
Mark R Woodford, Diana M Dunn, Joseph G Ciciarelli, Kristin Beebe, Len Neckers

Curr Top Med Chem· February 2017

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Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.
Thomas L Prince, Toshiki Kijima, Manabu Tatokoro, Sunmin Lee, Shinji Tsutsumi, Kristin Beebe

PLoS One· June 2016

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Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors.
Mark R Woodford, Andrew W Truman, Diana M Dunn, Sandra M Jensen, Richard Cotran, Kristin Beebe

Cell Rep· February 2016

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Regulation and function of the human HSP90AA1 gene.
Abbey D Zuehlke, Kristin Beebe, Len Neckers, Thomas Prince

Gene· October 2015

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Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas.
Harvey Schwartz, Brad Scroggins, Abbey Zuehlke, Toshiki Kijima, Kristin Beebe

Cell Stress Chaperones· September 2015

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Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands.
Sara Sattin, Jiahui Tao, Gerolamo Vettoretti, Elisabetta Moroni, Marzia Pennati, Kristin Beebe

Chemistry· September 2015

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Computational polypharmacology analysis of the heat shock protein 90 interactome.
Andrew Anighoro, Dagmar Stumpfe, Kathrin Heikamp, Kristin Beebe, Leonard M Neckers

J Chem Inf Model· March 2015

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Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors.
Mehdi Mollapour, Dimitra Bourboulia, Kristin Beebe, Mark R Woodford, Sigrun Polier

Mol Cell· January 2014

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The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models.
Naoto Miyajima, Shinji Tsutsumi, Carole Sourbier, Kristin Beebe, Mehdi Mollapour

Cancer Res· December 2013

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Synthesis and structure-activity relationship studies of novel dihydropyridones as androgen receptor modulators.
Antonella Pepe, Michael Pamment, Yeong Sang Kim, Sunmin Lee, Min-Jung Lee, Kristin Beebe

J Med Chem· November 2013

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Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors.
Kristin Beebe, Mehdi Mollapour, Bradley Scroggins, Chrisostomos Prodromou, Wanping Xu

Oncotarget· July 2013

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Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis.
Soichiro Yoshida, Shinji Tsutsumi, Guillaume Muhlebach, Carole Sourbier, Min-Jung Lee, Kristin Beebe

Proc Natl Acad Sci U S A· April 2013

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Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir.
Joong Sup Shim, Rajini Rao, Kristin Beebe, Len Neckers, Inkyu Han

J Natl Cancer Inst· October 2012

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Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine.
Wanping Xu, Mehdi Mollapour, Chrisostomos Prodromou, Suiquan Wang, Bradley T Scroggins, Kristin Beebe

Mol Cell· August 2012

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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.
Kamalika Moulick, James H Ahn, Hongliang Zong, Anna Rodina, Leandro Cerchietti, Kristin Beebe

Nat Chem Biol· September 2011

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