Publications by authors named "Kumar Alagramam"

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The potential of mitochondrially-targeted tetrapeptide in protecting against noise-induced hearing impairment.
Niranj A Kumar, Azmi Marouf, Kumar N Alagramam, Ruben Stepanyan

Neuroreport· February 2025

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Mucosal Injection of the Silicon Phthalocyanine Pc 4 in a Rabbit Model-A Pilot Study.
Nilam Patel, Isabel Held, Anna Trzcinska, Jay Wasman, Kumar N Alagramam

Laryngoscope· January 2025

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Usher syndrome IIIA: a review of the disorder and preclinical research advances in therapeutic approaches.
Azmi Marouf, Benjamin Johnson, Kumar N Alagramam

Hum Genet· April 2022

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Actin Crosslinking Family Protein 7 Deficiency Does Not Impair Hearing in Young Mice.
Benjamin L Gilbert, Shaoyuan Zhu, Ahlam Salameh, Shenyu Sun, Kumar N Alagramam

Front Cell Dev Biol· November 2021

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A biallelic variant in CLRN2 causes non-syndromic hearing loss in humans.
Barbara Vona, Neda Mazaheri, Sheng-Jia Lin, Lucy A Dunbar, Reza Maroofian, Kumar N Alagramam

Hum Genet· June 2021

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Mitochondrial calcium uniporter is essential for hearing and hair cell preservation in congenic FVB/NJ mice.
Mayakannan Manikandan, Steven Walker, Aditi R Deshmukh, Elizabeth Perea, Danqi Wang, Kumar N Alagramam

Sci Rep· May 2021

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Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.
Lucy A Dunbar, Pranav Patni, Carlos Aguilar, Philomena Mburu, Laura Corns, Kumar N Alagramam

EMBO Mol Med· September 2019

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Unconventional secretory pathway activation restores hair cell mechanotransduction in an USH3A model.
Suhasini R Gopal, Yvonne T Lee, Ruben Stepanyan, Brian M McDermott, Kumar N Alagramam

Proc Natl Acad Sci U S A· May 2019

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Inhibition of Mitochondrial Division Attenuates Cisplatin-Induced Toxicity in the Neuromast Hair Cells.
Jonathon W Vargo, Steven N Walker, Suhasini R Gopal, Aditi R Deshmukh, Brian M McDermott, Kumar N Alagramam

Front Cell Neurosci· December 2017

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Spatiotemporal changes in the distribution of LHFPL5 in mice cochlear hair bundles during development and in the absence of PCDH15.
Shanthini Mahendrasingam, Robert Fettiplace, Kumar N Alagramam, Ellen Cross, David N Furness

PLoS One· November 2017

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Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III.
Ruishuang Geng, Akil Omar, Suhasini R Gopal, Daniel H-C Chen, Ruben Stepanyan, Kumar N Alagramam

Sci Rep· October 2017

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A small molecule mitigates hearing loss in a mouse model of Usher syndrome III.
Kumar N Alagramam, Suhasini R Gopal, Ruishuang Geng, Daniel H-C Chen, Ina Nemet

Nat Chem Biol· June 2016

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Zebrafish Models for the Mechanosensory Hair Cell Dysfunction in Usher Syndrome 3 Reveal That Clarin-1 Is an Essential Hair Bundle Protein.
Suhasini R Gopal, Daniel H-C Chen, Shih-Wei Chou, Jingjing Zang, Stephan C F Neuhauss, Kumar N Alagramam

J Neurosci· July 2015

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Noise exposure immediately activates cochlear mitogen-activated protein kinase signaling.
Kumar N Alagramam, Ruben Stepanyan, Samson Jamesdaniel, Daniel H-C Chen, Rickie R Davis

Noise Health· January 2015

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Transient receptor potential melastatin 1: a hair cell transduction channel candidate.
John Gerka-Stuyt, Adrian Au, Neal S Peachey, Kumar N Alagramam

PLoS One· August 2014

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Ups and downs of Viagra: revisiting ototoxicity in the mouse model.
Adrian Au, John Gerka Stuyt, Daniel Chen, Kumar Alagramam

PLoS One· August 2014

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A mouse model validates the utility of electrocochleography in verifying endolymphatic hydrops.
Sami J Melki, Yiping Li, Maroun T Semaan, Qing Yin Zheng, Cliff A Megerian, Kumar N Alagramam

J Assoc Res Otolaryngol· June 2014

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ACF7 is a hair-bundle antecedent, positioned to integrate cuticular plate actin and somatic tubulin.
Patrick J Antonellis, Lana M Pollock, Shih-Wei Chou, Ahmed Hassan, Ruishuang Geng, Kumar N Alagramam

J Neurosci· January 2014

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Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells.
Ruishuang Geng, Marcos Sotomayor, Kimberly J Kinder, Suhasini R Gopal, John Gerka-Stuyt, Kumar N Alagramam

J Neurosci· March 2013

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The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene.
Ruishuang Geng, Sami Melki, Daniel H-C Chen, Guilian Tian, David N Furness, Kumar N Alagramam

J Neurosci· July 2012

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Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.
Kumar N Alagramam, Richard J Goodyear, Ruishuang Geng, David N Furness, Alexander F J van Aken

PLoS One· April 2011

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Pharmacological protection of hearing loss in the mouse model of endolymphatic hydrops.
Sami J Melki, Chris M Heddon, Jonathan K Frankel, Alex H Levitt, Suhael R Momin, Kumar N Alagramam

Laryngoscope· August 2010

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Proteomics, bioinformatics and targeted gene expression analysis reveals up-regulation of cochlin and identifies other potential biomarkers in the mouse model for deafness in Usher syndrome type 1F.
Mark R Chance, Jinsook Chang, Shuqing Liu, Giridharan Gokulrangan, Daniel H-C Chen, Kumar Alagramam

Hum Mol Genet· April 2010

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N-Acetyl L-Cysteine does not protect mouse ears from the effects of noise*.
Rickie R Davis, David A Custer, Edward Krieg, Kumar Alagramam

J Occup Med Toxicol· April 2010

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Surgical induction of endolymphatic hydrops by obliteration of the endolymphatic duct.
Cliff A Megerian, Chris Heddon, Sami Melki, Suhael Momin, Janis Paulsey, Kumar Alagramam

J Vis Exp· January 2010

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