Publications by authors named "Kurt Giles"

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CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model.
Noah R Johnson, Peng Yuan, Erika Castillo, T Peter Lopez, Weizhou Yue, Kurt Giles

Nat Commun· January 2023

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Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein.
Zuzana Krejciova, George A Carlson, Kurt Giles, Stanley B Prusiner

Acta Neuropathol Commun· May 2019

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α-Synuclein: Multiple System Atrophy Prions.
Amanda L Woerman, Joel C Watts, Atsushi Aoyagi, Kurt Giles, Lefkos T Middleton

Cold Spring Harb Perspect Med· July 2018

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Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.
Carlo Condello, Thomas Lemmin, Jan Stöhr, Mimi Nick, Yibing Wu, Kurt Giles

Proc Natl Acad Sci U S A· January 2018

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Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.
Noah R Johnson, Carlo Condello, Shenheng Guan, Abby Oehler, Julia Becker, Kurt Giles

Proc Natl Acad Sci U S A· December 2017

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A novel vector for transgenesis in the rat CNS.
T Peter Lopez, Kurt Giles, Brittany N Dugger, Abby Oehler, Carlo Condello

Acta Neuropathol Commun· November 2017

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Bioassays and Inactivation of Prions.
Kurt Giles, Amanda L Woerman, David B Berry, Stanley B Prusiner

Cold Spring Harb Perspect Biol· August 2017

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Developing Therapeutics for PrP Prion Diseases.
Kurt Giles, Steven H Olson, Stanley B Prusiner

Cold Spring Harb Perspect Med· April 2017

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Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions.
Joel C Watts, Kurt Giles, Daniel J Saltzberg, Brittany N Dugger, Smita Patel

J Virol· November 2016

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Towards authentic transgenic mouse models of heritable PrP prion diseases.
Joel C Watts, Kurt Giles, Matthew E C Bourkas, Smita Patel, Abby Oehler

Acta Neuropathol· October 2016

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Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice.
Kurt Giles, David B Berry, Carlo Condello, Brittany N Dugger, Zhe Li

J Pharmacol Exp Ther· September 2016

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Modulation of Creutzfeldt-Jakob disease prion propagation by the A224V mutation.
Joel C Watts, Kurt Giles, Ana Serban, Smita Patel, Abby Oehler

Ann Neurol· October 2015

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Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.
Kurt Giles, David B Berry, Carlo Condello, Ronald C Hawley, Alejandra Gallardo-Godoy

J Pharmacol Exp Ther· October 2015

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Propagation of prions causing synucleinopathies in cultured cells.
Amanda L Woerman, Jan Stöhr, Atsushi Aoyagi, Ryan Rampersaud, Zuzana Krejciova, Kurt Giles

Proc Natl Acad Sci U S A· September 2015

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Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.
Stanley B Prusiner, Amanda L Woerman, Daniel A Mordes, Joel C Watts, Ryan Rampersaud, Kurt Giles

Proc Natl Acad Sci U S A· September 2015

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Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice.
David Berry, Kurt Giles, Abby Oehler, Sumita Bhardwaj, Stephen J DeArmond

J Infect Dis· July 2015

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Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice.
Jan Stöhr, Carlo Condello, Joel C Watts, Lillian Bloch, Abby Oehler, Kurt Giles

Proc Natl Acad Sci U S A· July 2014

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Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients.
Joel C Watts, Carlo Condello, Jan Stöhr, Abby Oehler, Joanne Lee, Kurt Giles

Proc Natl Acad Sci U S A· July 2014

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Evidence that bank vole PrP is a universal acceptor for prions.
Joel C Watts, Kurt Giles, Smita Patel, Abby Oehler, Stephen J DeArmond

PLoS Pathog· April 2014

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Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells.
B Michael Silber, Joel R Gever, Satish Rao, Zhe Li, Adam R Renslo, Kurt Giles

Bioorg Med Chem· March 2014

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Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice.
Duo Lu, Kurt Giles, Zhe Li, Satish Rao, Elena Dolghih

J Pharmacol Exp Ther· November 2013

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Transmission of multiple system atrophy prions to transgenic mice.
Joel C Watts, Kurt Giles, Abby Oehler, Lefkos Middleton, David T Dexter

Proc Natl Acad Sci U S A· November 2013

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Drug resistance confounding prion therapeutics.
David B Berry, Duo Lu, Michal Geva, Joel C Watts, Sumita Bhardwaj, Kurt Giles

Proc Natl Acad Sci U S A· October 2013

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Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice.
B Michael Silber, Satish Rao, Kimberly L Fife, Alejandra Gallardo-Godoy, Adam R Renslo, Kurt Giles

Pharm Res· April 2013

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Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice.
Karah Nazor Friberg, Gene Hung, Ed Wancewicz, Kurt Giles, Chris Black

Mol Ther Nucleic Acids· February 2012

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