Publications by authors named "Kvido Strisovsky"

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Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization.
Mia L Abramsson, Robin A Corey, Jan L Skerle, Louise J Persson, Olivia Anden, Kvido Strisovsky

Elife· April 2025

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An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4.
Satarupa Bhaduri, Mac Kevin E Braza, Stancho Stanchev, Marina Tauber, Raghad Al-Bawab, Kvido Strisovsky

J Biol Chem· March 2025

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The zymogenic form of SARS-CoV-2 main protease: A discrete target for drug discovery.
Pavel Novotný, Jana Humpolíčková, Veronika Nováková, Stancho Stanchev, Kvido Stříšovský

J Biol Chem· January 2025

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4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL.
Shanping Ji, Kathrin Bach, Vijay Madhav Miriyala, Jan Dohnálek, Miguel Riopedre-Fernandez, Kvido Strisovsky

ACS Med Chem Lett· December 2024

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An platform for the enzymatic characterization of the rhomboid protease RHBDL4.
Satarupa Bhaduri, Mac Kevin E Braza, Stancho Stanchev, Marina Tauber, Raghad Al-Bawab, Kvido Strisovsky

bioRxiv· October 2024

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Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency.
Kathrin Bach, Jan Dohnálek, Jana Škerlová, Ján Kuzmík, Edita Poláchová, Kvido Strisovsky

Eur J Med Chem· September 2024

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Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis.
Abdulbasit Amin, Marina Badenes, Johanna Tüshaus, Érika de Carvalho, Emma Burbridge

Mol Metab· July 2023

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On the track of intramembrane clippers: the SPPL2a/b proteases caught in the act in animal models.
Květa Trávníčková, Kvido Stříšovský

FEBS J· May 2023

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Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy.
Edita Poláchová, Kathrin Bach, Elena Heuten, Stancho Stanchev, Anežka Tichá

J Med Chem· January 2023

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EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel.
Catarina J Gaspar, Lígia C Vieira, Cristiana C Santos, John C Christianson, David Jakubec, Kvido Strisovsky

EMBO Rep· January 2022

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Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation.
Adam G Grieve, Yi-Chun Yeh, Yu-Fen Chang, Hsin-Yi Huang, Lucrezia Zarcone

Mol Cell· December 2021

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Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms.
Marius K Lemberg, Kvido Strisovsky

Mol Cell· June 2021

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Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria.
Shiv Gandhi, Rosanna P Baker, Sangwoo Cho, Stancho Stanchev, Kvido Strisovsky

Cell Chem Biol· November 2020

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Rhomboid intramembrane protease YqgP licenses bacterial membrane protein quality control as adaptor of FtsH AAA protease.
Jakub Began, Baptiste Cordier, Jana Březinová, Jordan Delisle, Rozálie Hexnerová, Kvido Strisovsky

EMBO J· May 2020

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Bacterial rhomboid proteases mediate quality control of orphan membrane proteins.
Guangyu Liu, Stephen E Beaton, Adam G Grieve, Rhiannon Evans, Miranda Rogers, Kvido Strisovsky

EMBO J· May 2020

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Membrane Protein Dimerization in Cell-Derived Lipid Membranes Measured by FRET with MC Simulations.
Jan Škerle, Jana Humpolíčková, Nicholas Johnson, Petra Rampírová, Edita Poláchová, Kvido Strisovsky

Biophys J· April 2020

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Resolving oxidative damage to methionine by an unexpected membrane-associated stereoselective reductase discovered using chiral fluorescent probes.
Nikolai Makukhin, Václav Havelka, Edita Poláchová, Petra Rampírová, Vincenzo Tarallo, Kvido Strisovsky

FEBS J· October 2019

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The Rhomboid Superfamily: Structural Mechanisms and Chemical Biology Opportunities.
Anežka Tichá, Blanka Collis, Kvido Strisovsky

Trends Biochem Sci· September 2018

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iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.
Ioanna Oikonomidi, Emma Burbridge, Miguel Cavadas, Graeme Sullivan, Blanka Collis, Kvido Strisovsky

Elife· June 2018

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Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors.
Parul Goel, Thorsten Jumpertz, Anežka Tichá, Isabella Ogorek, David C Mikles, Kvido Strisovsky

Bioorg Med Chem Lett· May 2018

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Benzoxazin-4-ones as novel, easily accessible inhibitors for rhomboid proteases.
Jian Yang, Marta Barniol-Xicota, Minh T N Nguyen, Anezka Ticha, Kvido Strisovsky

Bioorg Med Chem Lett· May 2018

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General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.
Anežka Tichá, Stancho Stanchev, Kutti R Vinothkumar, David C Mikles, Petr Pachl, Kvido Strisovsky

Cell Chem Biol· December 2017

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Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.
Parul Goel, Thorsten Jumpertz, David C Mikles, Anežka Tichá, Minh T N Nguyen, Kvido Strisovsky

Biochemistry· December 2017

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Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis.
Nicholas Johnson, Jana Březinová, Elaine Stephens, Emma Burbridge, Matthew Freeman, Kvido Strisovsky

Sci Rep· August 2017

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Sensitive Versatile Fluorogenic Transmembrane Peptide Substrates for Rhomboid Intramembrane Proteases.
Anežka Tichá, Stancho Stanchev, Jan Škerle, Jakub Began, Marek Ingr, Kvido Strisovsky

J Biol Chem· February 2017

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