Publications by authors named "Kyle Chiang"

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A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis.
Leslie A Nangle, Zhiwen Xu, David Siefker, Christoph Burkart, Yeeting E Chong, Kyle P Chiang

Sci Transl Med· March 2025

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Novel AAV-mediated genome editing therapy improves health and survival in a mouse model of methylmalonic acidemia.
Shengwen Zhang, Amy Bastille, Susana Gordo, Nikhil Ramesh, Jenisha Vora, Kyle Chiang

PLoS One· September 2022

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Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses.
Ryan A Adams, Cátia Fernandes-Cerqueira, Antonella Notarnicola, Elisabeth Mertsching, Zhiwen Xu, Kyle P Chiang

Cell Mol Immunol· June 2021

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Promoterless, Nuclease-Free Genome Editing Confers a Growth Advantage for Corrected Hepatocytes in Mice With Methylmalonic Acidemia.
Randy J Chandler, Leah E Venturoni, Jing Liao, Brandon T Hubbard, Jessica L Schneller, Kyle Chiang

Hepatology· June 2021

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Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis.
Jie J Zhou, Feng Wang, Zhiwen Xu, Wing-Sze Lo, Ching-Fun Lau, Kyle P Chiang

J Biol Chem· July 2014

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Human tRNA synthetase catalytic nulls with diverse functions.
Wing-Sze Lo, Elisabeth Gardiner, Zhiwen Xu, Ching-Fun Lau, Feng Wang, Kyle P Chiang

Science· July 2014

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Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing.
Zhiwen Xu, Zhiyi Wei, Jie J Zhou, Fei Ye, Wing-Sze Lo, Kyle P Chiang

Structure· September 2012

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Cholesteryl ester hydrolase activity is abolished in HSL-/- macrophages but unchanged in macrophages lacking KIAA1363.
Marlene Buchebner, Thomas Pfeifer, Nora Rathke, Prakash G Chandak, Achim Lass, Kyle P Chiang

J Lipid Res· October 2010

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Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.
Robert K McGinty, Maja Köhn, Champak Chatterjee, Kyle P Chiang, Matthew R Pratt

ACS Chem Biol· November 2009

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A semisynthetic strategy to generate phosphorylated and acetylated histone H2B.
Kyle P Chiang, Mette S Jensen, Robert K McGinty, Tom W Muir

Chembiochem· September 2009

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Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe.
Matthew R Pratt, Matthew D Sekedat, Kyle P Chiang, Tom W Muir

Chem Biol· September 2009

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Systems- and molecular-level elucidation of signaling processes through chemistry.
Kyle P Chiang, Tom W Muir

Sci Signal· October 2008

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An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling.
Kyle P Chiang, Sherry Niessen, Alan Saghatelian, Benjamin F Cravatt

Chem Biol· October 2006

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Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions.
Daniel K Nomura, Kathleen A Durkin, Kyle P Chiang, Gary B Quistad, Benjamin F Cravatt

Chem Res Toxicol· September 2006

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Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state.
H Michael Petrassi, Steven M Johnson, Hans E Purkey, Kyle P Chiang, Traci Walkup

J Am Chem Soc· May 2005

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A brain detoxifying enzyme for organophosphorus nerve poisons.
Daniel K Nomura, Donmienne Leung, Kyle P Chiang, Gary B Quistad, Benjamin F Cravatt

Proc Natl Acad Sci U S A· April 2005

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Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
Steven M Johnson, H Michael Petrassi, Satheesh K Palaninathan, Nilofar N Mohamedmohaideen, Hans E Purkey, Kyle P Chiang

J Med Chem· March 2005

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Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors.
Hossein Razavi, Evan T Powers, Hans E Purkey, Sara L Adamski-Werner, Kyle P Chiang

Bioorg Med Chem Lett· February 2005

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Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use.
Kyle P Chiang, Alexandra L Gerber, Jack C Sipe, Benjamin F Cravatt

Hum Mol Genet· September 2004

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Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action.
Hossein Razavi, Satheesh K Palaninathan, Evan T Powers, R Luke Wiseman, Hans E Purkey, Kyle P Chiang

Angew Chem Int Ed Engl· June 2003

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A missense mutation in human fatty acid amide hydrolase associated with problem drug use.
Jack C Sipe, Kyle Chiang, Alexandra L Gerber, Ernest Beutler, Benjamin F Cravatt

Proc Natl Acad Sci U S A· June 2002

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Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors.
Vibha B Oza, Craig Smith, Prakash Raman, Edward K Koepf, Hilal A Lashuel, Kyle P Chiang

J Med Chem· January 2002

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