Publications by authors named "Kyle Denton"

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Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen.
Simon C C Lucas, J Henry Blackwell, Ulf Börjesson, David Hargreaves, Alexander G Milbradt, Kyle E Denton

ACS Med Chem Lett· June 2024

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Reduced C9orf72 expression exacerbates polyGR toxicity in patient iPSC-derived motor neurons and a Type I protein arginine methyltransferase inhibitor reduces that toxicity.
Therese L Dane, Anna L Gill, Fernando G Vieira, Kyle R Denton

Front Cell Neurosci· April 2023

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Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia.
Yongchao Mou, Yi Dong, Zhenyu Chen, Kyle R Denton, Michael O Duff

Acta Neuropathol Commun· December 2020

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Kinetic Heterogeneity of Cancer Cell Fractional Killing.
Zintis Inde, Giovanni C Forcina, Kyle Denton, Scott J Dixon

Cell Rep· July 2020

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Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor.
Sijie Wang, Kyle E Denton, Kathryn F Hobbs, Tyler Weaver, James M B McFarlane

ACS Chem Biol· January 2020

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Application of a Substrate-Mediated Selection with c-Src Tyrosine Kinase to a DNA-Encoded Chemical Library.
Dongwook Kim, Yixing Sun, Dan Xie, Kyle E Denton, Hao Chen

Molecules· July 2019

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Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias.
Kyle Denton, Yongchao Mou, Chong-Chong Xu, Dhruvi Shah, Jaerak Chang

Hum Mol Genet· July 2018

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Robustness of In Vitro Selection Assays of DNA-Encoded Peptidomimetic Ligands to CBX7 and CBX8.
Kyle E Denton, Sijie Wang, Michael C Gignac, Natalia Milosevich, Fraser Hof

SLAS Discov· June 2018

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Recapitulating and Correcting Marfan Syndrome in a Cellular Model.
Jung Woo Park, Li Yan, Chris Stoddard, Xiaofang Wang, Zhichao Yue, Kyle Denton

Int J Biol Sci· March 2018

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Modeling Axonal Defects in Hereditary Spastic Paraplegia with Human Pluripotent Stem Cells.
Kyle R Denton, Chongchong Xu, Harsh Shah, Xue-Jun Li

Front Biol (Beijing)· October 2016

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Crosslinking of DNA-linked ligands to target proteins for enrichment from DNA-encoded libraries.
Kyle E Denton, Casey J Krusemark

Medchemcomm· October 2016

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Modeling Axonal Phenotypes with Human Pluripotent Stem Cells.
Kyle R Denton, Chong-Chong Xu, Xue-Jun Li

Methods Mol Biol· August 2016

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Calcium/calmodulin-dependent protein kinase kinase β is neuroprotective in stroke in aged mice.
Lin Liu, Hui Yuan, Kyle Denton, Xue-Jun Li, Louise McCullough

Eur J Neurosci· August 2016

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Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke.
Hui Yuan, Kyle Denton, Lin Liu, Xue-Jun Li, Sharon Benashski

Neurobiol Dis· July 2016

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Abnormal mitochondrial transport and morphology as early pathological changes in human models of spinal muscular atrophy.
Chong-Chong Xu, Kyle R Denton, Zhi-Bo Wang, Xiaoqing Zhang, Xue-Jun Li

Dis Model Mech· January 2016

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Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A.
Peng-Peng Zhu, Kyle R Denton, Tyler Mark Pierson, Xue-Jun Li, Craig Blackstone

Hum Mol Genet· November 2014

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Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia.
Kyle R Denton, Ling Lei, Jeremy Grenier, Vladimir Rodionov, Craig Blackstone

Stem Cells· February 2014

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Identification of a possible respiratory arsenate reductase in Denitrovibrio acetiphilus, a member of the phylum Deferribacteres.
Kyle Denton, Morgan M Atkinson, Stacey P Borenstein, Alexis Carlson, Thomas Carroll

Arch Microbiol· September 2013

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The specification of telencephalic glutamatergic neurons from human pluripotent stem cells.
Erin M Boisvert, Kyle Denton, Ling Lei, Xue-Jun Li

J Vis Exp· April 2013

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