Publications by authors named "Kyle McCommis"

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At last: the mitochondrial pyruvate carrier structure revealed!
Brian N Finck, Christy M Hadfield, Kyle S McCommis

Trends Pharmacol Sci· July 2025

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A noncanonical cGAS-STING pathway drives cellular and organismal aging.
Rafael Cancado de Faria, Lilian N D Silva, Barbara Teodoro-Castro, Kyle S McCommis, Elena V Shashkova

Proc Natl Acad Sci U S A· July 2025

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Loss of mitochondrial pyruvate transport initiates cardiac glycogen accumulation and heart failure.
Rachel C Weiss, Kelly D Pyles, Kevin Cho, Michelle Brennan, Jonathan S Fisher, Kyle S McCommis

bioRxiv· April 2025

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A non-canonical cGAS-STING pathway drives cellular and organismal aging.
Rafael Cancado de Faria, Lilian Silva, Barbara Teodoro-Castro, Kyle S McCommis, Elena V Shashkova

bioRxiv· April 2025

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2-Chloro- and 2-Bromopalmitic acids inhibit mitochondrial function in airway epithelial cells.
Karina Ricart, Kyle S McCommis, David A Ford, Rakesh P Patel

Adv Redox Res· March 2025

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Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier.
Lingaiah Maram, Jessica M Michael, Henry Politte, Vaishnavi S Srirama, Aymen Hadji, Kyle S McCommis

Eur J Med Chem· February 2025

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Metabolic dysfunction and insulin sensitizers in acute and chronic disease.
Jerry R Colca, Kyle S McCommis

Expert Opin Investig Drugs· February 2025

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Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer.
Ronald Fowle-Grider, Joe L Rowles, Isabel Shen, Yahui Wang, Michaela Schwaiger-Haber, Kyle S McCommis

Nature· December 2024

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Momordicine-I suppresses head and neck cancer growth by modulating key metabolic pathways.
Debojyoty Bandyopadhyay, Ellen T Tran, Ruchi A Patel, Matthew A Luetzen, Kevin Cho, Kyle S McCommis

Cell Commun Signal· December 2024

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Membrane lipid nanodomains modulate HCN pacemaker channels in nociceptor DRG neurons.
Lucas J Handlin, Natalie L Macchi, Nicolas L A Dumaire, Lyuba Salih, Erin N Lessie, Kyle S McCommis

Nat Commun· November 2024

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Membrane Lipid Nanodomains Modulate HCN Pacemaker Channels in Nociceptor DRG Neurons.
Lucas J Handlin, Natalie L Macchi, Nicolas L A Dumaire, Lyuba Salih, Erin N Lessie, Kyle S McCommis

bioRxiv· September 2024

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Etomoxir: an old dog with new tricks.
Reagan M McGuffee, Kyle S McCommis, David A Ford

J Lipid Res· September 2024

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Ketone Body Metabolism is Not Required for Improvement of Heart Failure by Ketogenic Diet in Mice.
Zachary Foulks, Carla J Weinheimer, Attila Kovacs, Jessica Michael, Kelly D Pyles, Kyle S McCommis

bioRxiv· September 2024

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Computational structural prediction and chemical inhibition of the human mitochondrial pyruvate carrier protein heterodimer complex.
Christy M Hadfield, John K Walker, Chris Arnatt, Kyle S McCommis

bioRxiv· August 2024

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Double Cyclization Tandem Mass for Identification and Quantification of Phosphatidylcholines Using Isobaric Six-Plex Capillary nLC-MS/MS.
Mahmoud Elhusseiny Mostafa, Julius Agongo, Scott F Grady, Kelly Pyles, Kyle S McCommis

J Am Soc Mass Spectrom· July 2024

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In chronic kidney disease altered cardiac metabolism precedes cardiac hypertrophy.
Matthew J Williams, Carmen M Halabi, Hiral M Patel, Zachary Joseph, Kyle McCommis

Am J Physiol Renal Physiol· May 2024

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Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk.
Alexander Piening, Emily Ebert, Carter Gottlieb, Niloufar Khojandi, Lindsey M Kuehm, Kyle S McCommis

Nat Commun· April 2024

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Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult.
Nicole K H Yiew, Joel H Vazquez, Michael R Martino, Stefanie Kennon-McGill, Jake R Price, Kyle S McCommis

Mol Metab· November 2023

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Metabolic Drivers and Rescuers of Heart Failure.
Rachel C Weiss, Thiago N Menezes, Kyle S McCommis

Mo Med· November 2023

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Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo.
Sandip Mukherjee, Molee Chakraborty, Eliwaza N Msengi, Jake Haubner, Jinsong Zhang, Kyle S McCommis

Mol Metab· September 2023

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Editorial: Diabetes and non-alcoholic fatty liver disease: points of physiological and mechanistic intersection and current co-therapeutic approaches.
Nick Giannoukakis, Kyle S McCommis

Front Endocrinol (Lausanne)· August 2023

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Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism.
Daniel Ferguson, Sophie J Eichler, Nicole K H Yiew, Jerry R Colca, Kevin Cho, Kyle S McCommis

Mol Metab· April 2023

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Enhancing Hepatic MBOAT7 Expression in Mice With Nonalcoholic Steatohepatitis.
Martin C Sharpe, Kelly D Pyles, Taylor Hallcox, Dakota R Kamm, Michaela Piechowski, Kyle S McCommis

Gastro Hep Adv· February 2023

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A DUAL MTOR/NAD+ ACTING GEROTHERAPY.
Jinmei Li, Sandeep Kumar, Kirill Miachin, Nicholas L Bean, Ornella Halawi, Kyle S McCommis

bioRxiv· January 2023

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The Hepatic Mitochondrial Pyruvate Carrier as a Regulator of Systemic Metabolism and a Therapeutic Target for Treating Metabolic Disease.
Kyle S McCommis, Brian N Finck

Biomolecules· January 2023

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