Publications by authors named "Kyle Seamon"

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Correction: Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.
Jingjing Jiang, Lingyan Jiang, Benjamin J Maldonato, Yingyun Wang, Matthew Holderfield, Kyle J Seamon

Cancer Discov· October 2025

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A neomorphic protein interface catalyzes covalent inhibition of RAS aspartic acid in tumors.
Caroline Weller, G Leslie Burnett, Lingyan Jiang, Sujata Chakraborty, Dongyu Zhang, Kyle Seamon

Science· July 2025

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Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers.
James Cregg, Kristof Pota, Aidan C A Tomlinson, Jason Yano, Abby Marquez, Kyle J Seamon

J Med Chem· March 2025

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Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.
Jingjing Jiang, Lingyan Jiang, Benjamin J Maldonato, Yingyun Wang, Matthew Holderfield, Kyle J Seamon

Cancer Discov· June 2024

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Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Matthew Holderfield, Bianca J Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J Seamon

Nature· May 2024

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Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS.
Christopher J Schulze, Kyle J Seamon, Yulei Zhao, Yu C Yang, Jim Cregg

Science· August 2023

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Inhibition of Human Uracil DNA Glycosylase Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-Fluorodeoxyuridine and Raltitrexed but Not Fluorouracil.
Eric S Christenson, Anthony Gizzi, Junru Cui, Matthew Egleston, Kyle J Seamon

Mol Pharmacol· June 2021

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Use of anti-CRISPR protein AcrIIA4 as a capture ligand for CRISPR/Cas9 detection.
Robert K Johnston, Kyle J Seamon, Edwin A Saada, Joshua D Podlevsky, Steven S Branda

Biosens Bioelectron· September 2019

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Ultrasensitive Multi-Species Detection of CRISPR-Cas9 by a Portable Centrifugal Microfluidic Platform.
Christopher R Phaneuf, Kyle J Seamon, Tyler P Eckles, Anchal Sinha, Joseph S Schoeniger

Anal Methods· February 2019

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Versatile High-Throughput Fluorescence Assay for Monitoring Cas9 Activity.
Kyle J Seamon, Yooli K Light, Edwin A Saada, Joseph S Schoeniger, Brooke Harmon

Anal Chem· June 2018

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Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer.
Kyle J Seamon, Namandjé N Bumpus, James T Stivers

Biochemistry· November 2016

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A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase.
Kyle J Seamon, James T Stivers

J Biomol Screen· July 2015

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SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity.
Kyle J Seamon, Zhiqiang Sun, Luda S Shlyakhtenko, Yuri L Lyubchenko, James T Stivers

Nucleic Acids Res· July 2015

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Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.
Kyle J Seamon, Erik C Hansen, Anastasia P Kadina, Boris A Kashemirov, Charles E McKenna

J Am Chem Soc· July 2014

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GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state.
Erik C Hansen, Kyle J Seamon, Shannen L Cravens, James T Stivers

Proc Natl Acad Sci U S A· May 2014

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Intravenous fish oil lipid emulsion promotes a shift toward anti-inflammatory proresolving lipid mediators.
Brian T Kalish, Hau D Le, Jonathan M Fitzgerald, Samantha Wang, Kyle Seamon

Am J Physiol Gastrointest Liver Physiol· December 2013

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Estrogen negatively regulates epithelial wound healing and protective lipid mediator circuits in the cornea.
Samantha B Wang, Kyle M Hu, Kyle J Seamon, Vinidhra Mani, Yangdi Chen

FASEB J· April 2012

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