Publications by authors named "Kyle V Butler"

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MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing.
Tamara Vital, Aminah Wali, Kyle V Butler, Yan Xiong, Joseph P Foster

Front Oncol· January 2023

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Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery.
Anna M Chiarella, Kyle V Butler, Berkley E Gryder, Dongbo Lu, Tiffany A Wang

Nat Biotechnol· January 2020

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Pathway-Based High-Throughput Chemical Screen Identifies Compounds That Decouple Heterochromatin Transformations.
Ian A MacDonald, Kyle V Butler, Laura E Herring, Sarah E Clinkscales, Ramesh Yelagandula

SLAS Discov· September 2019

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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers.
Anna M Chiarella, Tiffany A Wang, Kyle V Butler, Jian Jin, Nathaniel A Hathaway

J Vis Exp· September 2018

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Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs.
John D McCorvy, Kyle V Butler, Brendan Kelly, Katie Rechsteiner, Joel Karpiak

Nat Chem Biol· February 2018

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Targeted Gene Repression Using Novel Bifunctional Molecules to Harness Endogenous Histone Deacetylation Activity.
Kyle V Butler, Anna M Chiarella, Jian Jin, Nathaniel A Hathaway

ACS Synth Biol· January 2018

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Report and Application of a Tool Compound Data Set.
Kyle V Butler, Ian A MacDonald, Nathaniel A Hathaway, Jian Jin

J Chem Inf Model· November 2017

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Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase.
Rinku Jain, Kyle V Butler, Javier Coloma, Jian Jin, Aneel K Aggarwal

Sci Rep· May 2017

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Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists.
Xin Chen, John D McCorvy, Matthew G Fischer, Kyle V Butler, Yudao Shen

J Med Chem· December 2016

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Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
Kyle V Butler, Anqi Ma, Wenyu Yu, Fengling Li, Wolfram Tempel

J Med Chem· November 2016

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Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase.
Kyle V Butler, Kelsey Bohn, Christine A Hrycyna, Jian Jin

Medchemcomm· May 2016

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A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.
Mohammad S Eram, Yudao Shen, Magdalena Szewczyk, Hong Wu, Guillermo Senisterra, Kyle V Butler

ACS Chem Biol· March 2016

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Structure-activity relationship studies of SETD8 inhibitors.
Anqi Ma, Wenyu Yu, Yan Xiong, Kyle V Butler, Peter J Brown

Medchemcomm· December 2014

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Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.
Anqi Ma, Wenyu Yu, Fengling Li, Rachel M Bleich, J Martin Herold, Kyle V Butler

J Med Chem· August 2014

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Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues.
Liang Xu, Kyle Vincent Butler, Jenny Chong, Jesper Wengel, Eric T Kool

Nucleic Acids Res· May 2014

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Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells.
Jay H Kalin, Kyle V Butler, Tatiana Akimova, Wayne W Hancock, Alan P Kozikowski

J Med Chem· January 2012

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Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.
Kyle V Butler, Jay Kalin, Camille Brochier, Guilio Vistoli, Brett Langley

J Am Chem Soc· August 2010

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Stereoselective HDAC inhibition from cysteine-derived zinc-binding groups.
Kyle V Butler, Rong He, Kathryn McLaughlin, Giulio Vistoli, Brett Langley

ChemMedChem· August 2009

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Creating zinc monkey wrenches in the treatment of epigenetic disorders.
Jay Hans Kalin, Kyle Vincent Butler, Alan Paul Kozikowski

Curr Opin Chem Biol· June 2009

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Novel inhibitors of human histone deacetylase (HDAC) identified by QSAR modeling of known inhibitors, virtual screening, and experimental validation.
Hao Tang, Xiang S Wang, Xi-Ping Huang, Bryan L Roth, Kyle V Butler

J Chem Inf Model· February 2009

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Chemical origins of isoform selectivity in histone deacetylase inhibitors.
Kyle V Butler, Alan P Kozikowski

Curr Pharm Des· May 2008

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