Publications by authors named "Laird Bloom"

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Metabolic Engineering of Glycofusion Bispecific Antibodies for α-Dystroglycanopathies.
Xiaotian Zhong, Guoying Grace Yan, Apurva Chaturvedi, Xiuling Li, Yijie Gao, Laird Bloom

Antibodies (Basel)· October 2024

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Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors.
Adam R Root, Gurkan Guntas, Madan Katragadda, James R Apgar, Jatin Narula, Laird Bloom

MAbs· October 2021

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affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states .
Edwina Stack, Sheridan McMurray, Gordon McMurray, Jason Wade, Melissa Clark, Laird Bloom

MAbs· May 2021

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A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers.
Divya Mathur, Adam R Root, Bozena Bugaj-Gaweda, Stephanie Bisulco, Xingzhi Tan, Laird Bloom

Clin Cancer Res· May 2020

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Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics.
Lindsay B Avery, Jason Wade, Mengmeng Wang, Amy Tam, Amy King, Laird Bloom

MAbs· January 2019

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Phage Display: A Powerful Technology for the Generation of High-Specificity Affinity Reagents from Alternative Immune Sources.
William J J Finlay, Laird Bloom, Joanne Grant, Edward Franklin, Deirdre Ní Shúilleabháin

Methods Mol Biol· January 2018

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Optimized Generation of High-Affinity, High-Specificity Single-Chain Fv Antibodies from Multi-Antigen Immunized Chickens.
William J J Finlay, Laird Bloom, Sreeja Varghese, Bénédicte Autin, Orla Cunningham

Methods Mol Biol· January 2018

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Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.
Adam R Root, Wei Cao, Bilian Li, Peter LaPan, Caryl Meade, Laird Bloom

Antibodies (Basel)· March 2016

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CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.
Brian J Fennell, Barry McDonnell, Amy Sze Pui Tam, Lijun Chang, John Steven, Laird Bloom

MAbs· January 2015

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Quantitative analysis of target coverage and germinal center response by a CXCL13 neutralizing antibody in a T-dependent mouse immunization model.
Joanne Brodfuehrer, Andrew Rankin, Jason Edmonds, Sean Keegan, Tatyana Andreyeva, Laird Bloom

Pharm Res· March 2014

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Comprehensive interrogation of a minimalist synthetic CDR-H3 library and its ability to generate antibodies with therapeutic potential.
Ciara M Mahon, Matthew A Lambert, Jacob Glanville, Jason M Wade, Brian J Fennell, Laird Bloom

J Mol Biol· May 2013

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IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.
Andrew L Rankin, Heath Guay, Deborah Herber, Sarah A Bertino, Tatyana A Duzanski, Laird Bloom

J Immunol· February 2012

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Fundamental characteristics of the immunoglobulin VH repertoire of chickens in comparison with those of humans, mice, and camelids.
Leeying Wu, Katarzyna Oficjalska, Matthew Lambert, Brian J Fennell, Alfredo Darmanin-Sheehan, Laird Bloom

J Immunol· January 2012

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Phage display: a powerful technology for the generation of high specificity affinity reagents from alternative immune sources.
William J J Finlay, Laird Bloom, Orla Cunningham

Methods Mol Biol· February 2011

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Optimized generation of high-affinity, high-specificity single-chain Fv antibodies from multiantigen immunized chickens.
William J J Finlay, Laird Bloom, Orla Cunningham

Methods Mol Biol· February 2011

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IL-21 receptor is critical for the development of memory B cell responses.
Andrew L Rankin, Heather MacLeod, Sean Keegan, Tatyana Andreyeva, Leslie Lowe, Laird Bloom

J Immunol· January 2011

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In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus.
Yulia Vugmeyster, Heath Guay, Pamela Szklut, Ming D Qian, Macy Jin, Laird Bloom

MAbs· December 2010

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Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody.
Yongjing Guo, Andrew A Hill, Renee C Ramsey, Frederick W Immermann, Christopher Corcoran, Laird Bloom

J Transl Med· May 2010

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Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood.
Maya Arai, Sadhana Jain, Amy A Weaver, Andrew A Hill, Yongjing Guo, Laird Bloom

J Transl Med· May 2010

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Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys.
Yulia Vugmeyster, Scott Allen, Pamela Szklut, Andrea Bree, Mark Ryan, Laird Bloom

J Transl Med· April 2010

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A human CXCL13-induced actin polymerization assay measured by fluorescence plate reader.
Jennifer Alley, Laird Bloom, Marion Kasaian, Huilan Gao, Gabriel Berstein

Assay Drug Dev Technol· February 2010

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FN3: a new protein scaffold reaches the clinic.
Laird Bloom, Valerie Calabro

Drug Discov Today· October 2009

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C. elegans CARMIL negatively regulates UNC-73/Trio function during neuronal development.
Pamela J Vanderzalm, Amita Pandey, Michael E Hurwitz, Laird Bloom, H Robert Horvitz

Development· April 2009

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Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans.
Michael E Hurwitz, Pamela J Vanderzalm, Laird Bloom, Julia Goldman, Gian Garriga

PLoS Biol· April 2009

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A simple high-throughput purification method for hit identification in protein screening.
Emma Cummins, Deborah P Luxenberg, Fionnuala McAleese, Angela Widom, Brian J Fennell, Laird Bloom

J Immunol Methods· November 2008

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