Publications by authors named "Larry Witte"

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Correction: Involvement of the VEGF receptor 3 in tubular morphogenesis demonstrated with a human antihuman VEGFR-3 monoclonal antibody that antagonizes receptor activation by VEGF-C.
Kris Persaud, Jean-Christophe Tille, Meilin Liu, Zhenping Zhu, Xenia Jimenez, Larry Witte

J Cell Sci· September 2023

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Estimating preclinical efficacy targets utilizing cetuximab efficacy in KRAS mutant and wild-type colorectal cancer models.
Marie Prewett, Rajiv Bassi, Keren Paz, Michael Amatulli, Dhanvanthri Deevi, Larry Witte

Anticancer Res· June 2011

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Pleiotropic stromal effects of vascular endothelial growth factor receptor 2 antibody therapy in renal cell carcinoma models.
Inga J Duignan, Erik Corcoran, Anthony Pennello, Mary Jane Plym, Michael Amatulli, Larry Witte

Neoplasia· January 2011

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Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells.
Jason M Butler, Daniel J Nolan, Eva L Vertes, Barbara Varnum-Finney, Hideki Kobayashi, Larry Witte

Cell Stem Cell· March 2010

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Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells.
Zhaojing Zhong, Kyla Driscoll Carroll, Desiree Policarpio, Carla Osborn, Michael Gregory, Larry Witte

Clin Cancer Res· February 2010

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Tumor necrosis factor-alpha and interleukin-1 antagonists alleviate inflammatory skin changes associated with epidermal growth factor receptor antibody therapy in mice.
David Surguladze, Dhanvanthri Deevi, Nidia Claros, Erik Corcoran, Su Wang, Larry Witte

Cancer Res· July 2009

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Development of a fully human anti-PDGFRbeta antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody.
Juqun Shen, Marie Danielle Vil, Marie Prewett, Chris Damoci, Haifan Zhang, Larry Witte

Neoplasia· June 2009

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Prioritization of EGFR/IGF-IR/VEGFR2 combination targeted therapies utilizing cancer models.
James R Tonra, Erik Corcoran, Dhanvanthri S Deevi, Philipp Steiner, Jessica Kearney, Larry Witte

Anticancer Res· June 2009

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Dose-dependent increases in circulating TGF-alpha and other EGFR ligands act as pharmacodynamic markers for optimal biological dosing of cetuximab and are tumor independent.
Anthony J Mutsaers, Giulio Francia, Shan Man, Christina R Lee, John M L Ebos, Larry Witte

Clin Cancer Res· April 2009

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Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells.
Andrea T Hooper, Jason M Butler, Daniel J Nolan, Andrea Kranz, Kaoruko Iida, Larry Witte

Cell Stem Cell· March 2009

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Long-term progression and therapeutic response of visceral metastatic disease non-invasively monitored in mouse urine using beta-human choriogonadotropin secreting tumor cell lines.
Giulio Francia, Urban Emmenegger, Christina R Lee, Yuval Shaked, Christopher Folkins, Larry Witte

Mol Cancer Ther· October 2008

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Inhibition of glioblastoma growth in a highly invasive nude mouse model can be achieved by targeting epidermal growth factor receptor but not vascular endothelial growth factor receptor-2.
Tobias Martens, Yvonne Laabs, Hauke S Günther, Dirk Kemming, Zhenping Zhu, Larry Witte

Clin Cancer Res· September 2008

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Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents.
Yuval Shaked, Erik Henke, Jeanine M L Roodhart, Patrizia Mancuso, Marlies H G Langenberg, Larry Witte

Cancer Cell· September 2008

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Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth.
Pirjo Laakkonen, Marika Waltari, Tanja Holopainen, Takashi Takahashi, Bronislaw Pytowski, Larry Witte

Cancer Res· January 2007

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The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma.
Yan Wu, Andrea T Hooper, Zhaojing Zhong, Larry Witte, Peter Bohlen

Int J Cancer· October 2006

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IMC-EB10, an anti-FLT3 monoclonal antibody, prolongs survival and reduces nonobese diabetic/severe combined immunodeficient engraftment of some acute lymphoblastic leukemia cell lines and primary leukemic samples.
Obdulio Piloto, Bao Nguyen, David Huso, Kyu-Tae Kim, Yiwen Li, Larry Witte

Cancer Res· May 2006

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A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity.
Dan Lu, Haifan Zhang, Henry Koo, James Tonra, Paul Balderes, Larry Witte

J Biol Chem· May 2005

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Conservation of receptor antagonist anti-tumor activity by epidermal growth factor receptor antibody expressed in transgenic corn seed.
Dale L Ludwig, Larry Witte, Daniel J Hicklin, Marie Prewett, Rajiv Bassi

Hum Antibodies· April 2005

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Targeting the platelet-derived growth factor receptor alpha with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: implications as a potential therapeutic target.
Nick Loizos, Yan Xu, Jim Huber, Meilin Liu, Dan Lu, Larry Witte

Mol Cancer Ther· March 2005

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A recombinant, fully human, bispecific antibody neutralizes the biological activities mediated by both vascular endothelial growth factor receptors 2 and 3.
Xenia Jimenez, Dan Lu, Laura Brennan, Kris Persaud, Meilin Liu, Larry Witte

Mol Cancer Ther· March 2005

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Inhibitory anti-FLT3 antibodies are capable of mediating antibody-dependent cell-mediated cytotoxicity and reducing engraftment of acute myelogenous leukemia blasts in nonobese diabetic/severe combined immunodeficient mice.
Obdulio Piloto, Mark Levis, David Huso, Yiwen Li, Hongli Li, Larry Witte

Cancer Res· February 2005

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Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody.
Bronislaw Pytowski, Jeremy Goldman, Kris Persaud, Yan Wu, Larry Witte

J Natl Cancer Inst· January 2005

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Inhibition of both the autocrine and the paracrine growth of human leukemia with a fully human antibody directed against vascular endothelial growth factor receptor 2.
Haifan Zhang, Yiwen Li, Hongli Li, Rajiv Bassi, Xenia Jimenez, Larry Witte

Leuk Lymphoma· September 2004

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Involvement of the VEGF receptor 3 in tubular morphogenesis demonstrated with a human anti-human VEGFR-3 monoclonal antibody that antagonizes receptor activation by VEGF-C.
Kris Persaud, Jean-Christophe Tille, Meilin Liu, Zhenping Zhu, Xenia Jimenez, Larry Witte

J Cell Sci· June 2004

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The effect of variable domain orientation and arrangement on the antigen-binding activity of a recombinant human bispecific diabody.
Dan Lu, Xenia Jimenez, Larry Witte, Zhenping Zhu

Biochem Biophys Res Commun· May 2004

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