Publications by authors named "Lars Wortmann"

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CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.
Oleksandra Herasymenko, Madhushika Silva, Abd Al-Aziz A Abu-Saleh, Ayaz Ahmad, Jesus Alvarado-Huayhuaz, Lars Wortmann

J Chem Inf Model· July 2025

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CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson's Disease Associated Protein.
Fengling Li, Suzanne Ackloo, Cheryl H Arrowsmith, Fuqiang Ban, Christopher J Barden, Lars Wortmann

J Chem Inf Model· November 2024

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Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science.
Sven Thamm, Marina K Willwacher, Gary E Aspnes, Tom Bretschneider, Nicholas F Brown, Lars Wortmann

J Med Chem· February 2023

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Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A.
Lars Wortmann, Nico Bräuer, Simon J Holton, Horst Irlbacher, Jörg Weiske

J Med Chem· November 2021

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BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies.
Markus Berger, Lars Wortmann, Philipp Buchgraber, Ulrich Lücking, Sabine Zitzmann-Kolbe

J Med Chem· September 2021

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Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.
Giacomo Cossa, Isabelle Roeschert, Florian Prinz, Apoorva Baluapuri, Raphael Silveira Vidal, Lars Wortmann

Mol Cell· June 2021

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Prey for the Proteasome: Targeted Protein Degradation-A Medicinal Chemist's Perspective.
Laura M Luh, Ulrike Scheib, Katrin Juenemann, Lars Wortmann, Michael Brands

Angew Chem Int Ed Engl· September 2020

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Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models.
Ulrich Lücking, Lars Wortmann, Antje M Wengner, Julien Lefranc, Philip Lienau

J Med Chem· July 2020

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Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription.
Giacomo Cossa, Isabelle Roeschert, Florian Prinz, Apoorva Baluapuri, Raphael Silveira Vidal, Lars Wortmann

Mol Cell· March 2020

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The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models.
Antje M Wengner, Gerhard Siemeister, Ulrich Lücking, Julien Lefranc, Lars Wortmann

Mol Cancer Ther· January 2020

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Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo.
Lars Wortmann, Bernhard Lindenthal, Peter Muhn, Alexander Walter, Reinhard Nubbemeyer

J Med Chem· November 2019

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Roman C Hillig, Brice Sautier, Jens Schroeder, Dieter Moosmayer, André Hilpmann, Lars Wortmann

Proc Natl Acad Sci U S A· February 2019

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Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.
Duy Nguyen, Clara Lemos, Lars Wortmann, Knut Eis, Simon J Holton

J Med Chem· January 2019

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Latest Advances Towards Ras Inhibition: A Medicinal Chemistry Perspective.
Brice Sautier, Carl F Nising, Lars Wortmann

Angew Chem Int Ed Engl· December 2016

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Novel and efficient copper-catalysed synthesis of nitrogen-linked medium-ring biaryls.
Jayne L Kenwright, Warren R J D Galloway, David T Blackwell, Albert Isidro-Llobet, James Hodgkinson, Lars Wortmann

Chemistry· March 2011

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Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis.
Anna Santamaria, Rüdiger Neef, Uwe Eberspächer, Knut Eis, Manfred Husemann, Lars Wortmann

Mol Biol Cell· October 2007

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