Publications by authors named "Laura Humphrys"

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Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing.
Jessica J Lu, Giuseppe Deganutti, Miaomiao Li, Laura J Humphrys, Yandi Li

Proc Natl Acad Sci U S A· November 2025

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The dark sides of the GPCR tree - research progress on understudied GPCRs.
Magdalena M Scharf, Laura J Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann

Br J Pharmacol· July 2025

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Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors.
Grace Mennen, Zi Ying, Madeleine M Fletcher, Muhammad Abdur Razzak, Laura Humphrys

Biochemistry· June 2025

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Guanidine Derivative ADS1017, a Potent Histamine H Receptor Antagonist with Promising Analgesic Activity and Satisfactory Safety Profile.
Tadeusz Karcz, Katarzyna Szczepańska, Szczepan Mogilski, Aleksandra Moroz, Agnieszka Olejarz-Maciej, Laura J Humphrys

ACS Chem Neurosci· December 2024

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The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis.
Emanuela Talamonti, Jelena Davegardh, Anastasia Kalinovich, Sten M M van Beek, Nodi Dehvari, Laura J Humphrys

Mol Metab· July 2024

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Illuminating Neuropeptide Y Y Receptor Binding: Fluorescent Cyclic Peptides with Subnanomolar Binding Affinity as Novel Molecular Tools.
Jakob Gleixner, Sergei Kopanchuk, Lukas Grätz, Maris-Johanna Tahk, Tõnis Laasfeld, Laura J Humphrys

ACS Pharmacol Transl Sci· April 2024

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Activation of Multiple G Protein Pathways to Characterize the Five Dopamine Receptor Subtypes Using Bioluminescence Technology.
Denise Mönnich, Laura J Humphrys, Carina Höring, Bradley L Hoare, Lisa Forster

ACS Pharmacol Transl Sci· March 2024

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Lysergic acid diethylamide stimulates cardiac human H histamine and cardiac human 5-HT-serotonin receptors.
Ulrich Gergs, Hannes Jacob, Pauline Braekow, Britt Hofmann, Steffen Pockes, Laura J Humphrys

Naunyn Schmiedebergs Arch Pharmacol· January 2024

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Clonidine stimulates force of contraction via histamine H receptors in the human atrium.
Joachim Neumann, Steffen Pockes, Laura J Humphrys, Denise Mönnich, Lisa Forster

Naunyn Schmiedebergs Arch Pharmacol· January 2024

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Ergometrine stimulates histamine H receptors in the isolated human atrium.
Hannes Jacob, Pauline Braekow, Britt Hofmann, Uwe Kirchhefer, Lisa Forster, Laura J Humphrys

Naunyn Schmiedebergs Arch Pharmacol· December 2023

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[H]UR-JG102-A Radiolabeled Cyclic Peptide with High Affinity and Excellent Selectivity for the Neuropeptide Y Y Receptor.
Jakob Gleixner, Albert O Gattor, Laura J Humphrys, Thomas Brunner, Max Keller

J Med Chem· October 2023

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Dual Piperidine-Based Histamine H and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain.
Katarzyna Szczepańska, Tadeusz Karcz, Maria Dichiara, Szczepan Mogilski, Justyna Kalinowska-Tłuścik, Laura J Humphrys

J Med Chem· July 2023

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Stereochemistry-Driven Interactions of α,γ-Peptide Ligands with the Neuropeptide Y Y-Receptor.
Eva Plut, Jacqueline C Calderón, Vesna Stanojlović, Albert O Gattor, Carina Höring, Laura J Humphrys

J Med Chem· July 2023

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Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias.
Hannes Schihada, Thomas M Klompstra, Laura J Humphrys, Igor Cervenka, Shamim Dadvar

J Biol Chem· September 2022

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A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H Receptor.
Niklas Rosier, Lukas Grätz, Hannes Schihada, Jan Möller, Ali Işbilir, Laura J Humphrys

J Med Chem· August 2021

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A G protein-coupled receptor dimer imaging assay reveals selectively modified pharmacology of neuropeptide Y Y1/Y5 receptor heterodimers.
Laura E Kilpatrick, Laura J Humphrys, Nicholas D Holliday

Mol Pharmacol· April 2015

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