Publications by authors named "Laura Randle"

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Targeting the tumor microenvironment in cholangiocarcinoma to improve immune checkpoint blockade: potential strategies and translational pre-clinical models.
Maria-Danae Jessel, Owen McGreevy, Lauryn McReynolds, Lekh N Dahal, Timothy Gilbert, Laura E Randle

Clin Transl Immunology· October 2025

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A Preclinical Model of Human Liver Using Precision Cut Tissue Slice Culture.
Owen McGreevy, Timothy Gilbert, Maria-Danae Jessel, Mohammed Bosakhar, Stephen Fenwick, Laura Randle

F1000Res· August 2025

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The importance of preclinical models in cholangiocarcinoma.
Owen McGreevy, Mohammed Bosakhar, Timothy Gilbert, Marc Quinn, Stephen Fenwick, Laura Randle

Eur J Surg Oncol· February 2025

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Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture.
Ross A Kelly, Joseph Leedale, Andy Harrell, Daniel A Beard, Laura E Randle

PLoS One· April 2019

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Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor In Vivo Using Fluorinated Bisquinolines.
Alistair J Fielding, Valentina Lukinović, Philip G Evans, Said Alizadeh-Shekalgourabi, Roger H Bisby, Laura E Randle

Chemistry· May 2017

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The generation, detection, and effects of reactive drug metabolites.
Andrew V Stachulski, Thomas A Baillie, B Kevin Park, R Scott Obach, Deepak K Dalvie, Laura E Randle

Med Res Rev· September 2013

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Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.
Neil R Kitteringham, Azman Abdullah, Joanne Walsh, Laura Randle, Rosalind E Jenkins

J Proteomics· June 2010

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The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system.
Ian M Copple, Christopher E Goldring, Rosalind E Jenkins, Alvin J L Chia, Laura E Randle

Hepatology· October 2008

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Investigation of the effect of a panel of model hepatotoxins on the Nrf2-Keap1 defence response pathway in CD-1 mice.
Laura E Randle, Chris E P Goldring, Craig A Benson, Peter N Metcalfe, Neil R Kitteringham

Toxicology· January 2008

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The metabolism and toxicity of furosemide in the Wistar rat and CD-1 mouse: a chemical and biochemical definition of the toxicophore.
Dominic P Williams, Daniel J Antoine, Philip J Butler, Russell Jones, Laura Randle

J Pharmacol Exp Ther· September 2007

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Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes.
Chris E P Goldring, Neil R Kitteringham, Rosalind Jenkins, Cerys A Lovatt, Laura E Randle

Am J Physiol Cell Physiol· January 2006

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Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice.
Christopher E P Goldring, Neil R Kitteringham, Robert Elsby, Laura E Randle, Yuri N Clement

Hepatology· May 2004

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Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials.
Paul M O'Neill, Amira Mukhtar, Paul A Stocks, Laura E Randle, Stephen Hindley

J Med Chem· November 2003

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