Publications by authors named "Robert Elsby"

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Mechanistic in vitro studies indicate that the clinical drug-drug interactions between protease inhibitors and rosuvastatin are driven by inhibition of intestinal BCRP and hepatic OATP1B1 with minimal contribution from OATP1B3, NTCP and OAT3.
Robert Elsby, Hannah Coghlan, Jacob Edgerton, David Hodgson, Samuel Outteridge

Pharmacol Res Perspect· April 2023

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Studying the right transporter at the right time: an strategy for assessing drug-drug interaction risk during drug discovery and development.
Robert Elsby, Hayley Atkinson, Philip Butler, Robert J Riley

Expert Opin Drug Metab Toxicol· October 2022

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Mechanistic In Vitro Studies Indicate that the Clinical Drug-Drug Interaction between Telithromycin and Simvastatin Acid Is Driven by Time-Dependent Inhibition of CYP3A4 with Minimal Effect on OATP1B1.
Robert Elsby, Victoria Hare, Hannah Neal, Samuel Outteridge, Catherine Pearson

Drug Metab Dispos· January 2019

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Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine.
Robert Elsby, Stephen Chidlaw, Samuel Outteridge, Sarah Pickering, Amy Radcliffe

Pharmacol Res Perspect· October 2017

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Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure.
Robert Elsby, Paul Martin, Dominic Surry, Pradeep Sharma, Katherine Fenner

Drug Metab Dispos· March 2016

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Effects of Fostamatinib on the Pharmacokinetics of Digoxin (a P-Glycoprotein Substrate): Results From in Vitro and Phase I Clinical Studies.
Paul Martin, Michael Gillen, David Millson, Stuart Oliver, Clive Brealey, Robert Elsby

Clin Ther· December 2015

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Rosuvastatin pharmacokinetics and pharmacogenetics in Caucasian and Asian subjects residing in the United States.
Bruce K Birmingham, Sarah R Bujac, Robert Elsby, Connie T Azumaya, Julie Zalikowski

Eur J Clin Pharmacol· March 2015

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Impact of ABCG2 and SLCO1B1 polymorphisms on pharmacokinetics of rosuvastatin, atorvastatin and simvastatin acid in Caucasian and Asian subjects: a class effect?
Bruce K Birmingham, Sarah R Bujac, Robert Elsby, Connie T Azumaya, Cheryl Wei

Eur J Clin Pharmacol· March 2015

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The use of bioreactors as in vitro models in pharmaceutical research.
Maaria Ginai, Robert Elsby, Christopher J Hewitt, Dominic Surry, Katherine Fenner

Drug Discov Today· October 2013

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Prediction of the in vivo OATP1B1-mediated drug-drug interaction potential of an investigational drug against a range of statins.
Pradeep Sharma, Caroline J Butters, Veronica Smith, Robert Elsby, Dominic Surry

Eur J Pharm Sci· August 2012

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Validation of membrane vesicle-based breast cancer resistance protein and multidrug resistance protein 2 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions.
Robert Elsby, Veronica Smith, Lisa Fox, David Stresser, Caroline Butters

Xenobiotica· September 2011

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In vitro risk assessment of AZD9056 perpetrating a transporter-mediated drug-drug interaction with methotrexate.
Robert Elsby, Lisa Fox, David Stresser, Mark Layton, Caroline Butters

Eur J Pharm Sci· May 2011

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The utility of in vitro data in making accurate predictions of human P-glycoprotein-mediated drug-drug interactions: a case study for AZD5672.
Robert Elsby, Michael Gillen, Caroline Butters, Gemma Imisson, Pradeep Sharma

Drug Metab Dispos· February 2011

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Relative and absolute quantitative expression profiling of cytochromes P450 using isotope-coded affinity tags.
Rosalind E Jenkins, Neil R Kitteringham, Christie L Hunter, Sally Webb, Tony J Hunt, Robert Elsby

Proteomics· March 2006

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Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice.
Christopher E P Goldring, Neil R Kitteringham, Robert Elsby, Laura E Randle, Yuri N Clement

Hepatology· May 2004

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Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.
Robert Elsby, Neil R Kitteringham, Christopher E Goldring, Cerys A Lovatt, Mark Chamberlain

J Biol Chem· June 2003

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Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver.
Neil R Kitteringham, Helen Powell, Rosalind E Jenkins, Jane Hamlett, Cerys Lovatt, Robert Elsby

Proteomics· February 2003

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